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The Journal of Clinical Endocrinology & Metabolism Vol. 85, No. 8 2970-2973
Copyright © 2000 by The Endocrine Society

Rapid Communications

Glucose Challenge Stimulates Reactive Oxygen Species (ROS) Generation by Leucocytes

Priya Mohanty, Wael Hamouda, Rajesh Garg, Ahmad Aljada, Husam Ghanim and Paresh Dandona

Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York 14209

Abstract

Diabetes mellitus is associated with increased ROS generation, oxidative injury and obesity. To elucidate the relationship between nutrition and ROS generation, we have investigated the effect of glucose challenge on ROS generation by leucocytes, p47phox protein, a key protein in the enzyme NADPH oxidase and {alpha}-tocopherol levels. Blood samples were drawn from 14 normal subjects prior to, at 1, 2 and 3 h following ingestion of 75 g glucose. ROS generation by polymorphonuclear leucocytes (PMNL) and mononuclear cells (MNC) increased to a peak of 244 ± 42% and 233 ± 34% of the basal respectively at 2 h. The levels of p47phox in MNC homogenates increased significantly at 2 h and 3 h after glucose intake. {alpha}-Tocopherol levels decreased significantly at 1 h, 2 h, and 3 h. We conclude that glucose intake stimulates ROS generation and p47phox of NADPH oxidase; increases oxidative load and causes a fall in {alpha}-tocopherol concentration.




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