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The Journal of Clinical Endocrinology & Metabolism Vol. 85, No. 12 4921
Copyright © 2000 by The Endocrine Society


Letters to the Editor

Authors’ Response: Isolated Familial Somatotropinomas: Does the Disease Map to 11q13 or to 2p16?

Monica R. Gadelha, Klaus Rhode, Rhonda D. Kineman and Lawrence A. Frohman

Department of Medicine (M.R.G., R.D.K., L.A.F.), University of Illinois at Chicago, Chicago, Illinois 60612; Division of Endocrinology (M.R.G.), Clementino Fraga Filho University Hospital, Federal University of Rio De Janeiro, Rio De Janeiro, Brazil 21919-590; and Department of Bioinformatics (K.R.), Max Delbrück Center for Molecular Medicine, d-13092 Berlin, Germany {hd2}To the editor:

Received September 13, 2000.

References

  1. Stratakis CA, Jenkins RB, Pras E, et al. 1996 Cytogenetic and microsatellite alterations in tumors from patients with the syndrome of myxomas, spotty skin pigmentation, and endocrine overactivity (Carney complex). J Clin Endocrinol Metab. 81:3607–3614.[Abstract]
  2. Yamada S, Yoshimoto K, Sano T, et al. 1997 Inactivation of the tumor suppressor gene on 11q13 in brothers with familial acrogigantism without multiple endocrine neoplasia type 1. J Clin Endocrinol Metab. 82:239–242.[Abstract/Free Full Text]
  3. Lustbader E, Rebbeck TR, Buetow KH. 1995 Using loss of heterozygosity data in affected pedigree member linkage tests. Genet Epidemiol. 12:339–350.[CrossRef][Medline]
  4. Tomlinson I, Rahman N, Frayling I, et al. 1999 Inherited susceptibility to colorectal adenomas and carcinomas: evidence for a new predisposition gene on 15q14–q22. Gastroenterology. 116:789–795.[CrossRef][Medline]
  5. Gadelha MR, Une KN, Rhode K, Vaisman M, Kineman RD, Frohman LA. 2000 Isolated familial somatotropinomas: establishment of linkage to chromosome 11q13.1-11q13.3 and evidence for a potential second locus at chromosome 2p16–12. J Clin Endocrinol Metab. 85:707–714.[Abstract/Free Full Text]
  6. Gadelha MR, Kineman RD, Frohman LA. 1999 Familial somatotropinomas: clinical and genetic aspects. Endocrinologist. 9:277–285.
  7. Risch N. 1992 Genetic linkage: interpreting lod scores. Science. 255:803–804.[Free Full Text]



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