This Article Abstract Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Snyder, P. J. Articles by Strom, B. L. Search for Related Content PubMed PubMed Citation Articles by Snyder, P. J. Articles by Strom, B. L.

Effect of Testosterone Treatment on Body Composition and Muscle Strength in Men Over 65 Years of Age¹

Departments of Medicine (P.J.S., H.P., P.H., L.L., A.D., B.L.S.), Biostatistics and Epidemiology (J.A.B., J.H.H., J.S., B.L.S.), and Rehabilitation Medicine (D.A.L.), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104; and St. Joseph’s Hospital (C.J.R.), Bangor, Maine 04401

Address all correspondence and requests for reprints to: Dr. Peter J. Snyder, 3450 Hamilton Walk, Philadelphia, Pennsylvania 19104-6087.

	Abstract

Top Abstract Introduction Subjects and Methods Results Discussion References

 
As men age, serum testosterone concentrations decrease, the percentage of body mass that is fat increases, the percentage of lean body mass decreases, and muscle strength decreases. Because these changes are similar to those that occur in hypogonadal men, we hypothesized that increasing the serum testosterone concentration of men over 65 yr of age to that in young men would decrease their fat mass, increase their lean mass, and increase their muscle strength.

We randomized 108 men over 65 yr of age to wear either a testosterone patch or a placebo patch in a double blind study for 36 months. We measured body composition by dual energy x-ray absorptiometry and muscle strength by dynamometer before and during treatment. Ninety-six men completed the entire 36-month protocol.

Fat mass decreased (-3.0 ± 0.5 kg) in the testosterone-treated men during the 36 months of treatment, which was significantly different (P = 0.001) from the decrease (-0.7 ± 0.5 kg) in the placebo-treated men. Lean mass increased (1.9 ± 0.3 kg) in the testosterone-treated men, which was significantly different (P < 0.001) from that (0.2 ± 0.2 kg) in the placebo-treated men. The decrease in fat mass in the testosterone-treated men was principally in the arms (-0.7 ± 0.1 kg; P < 0.001 compared to the placebo group) and legs (-1.1 ± 0.2 kg; P < 0.001), and the increase in lean mass was principally in the trunk (1.9 ± 0.3 kg; P < 0.001). The change in strength of knee extension and flexion at 60° and 180° angular velocity during treatment, however, was not significantly different between the two groups.

We conclude that increasing the serum testosterone concentrations of normal men over 65 yr of age to the midnormal range for young men decreased fat mass, principally in the arms and legs, and increased lean mass, principally in the trunk, but did not increase the strength of knee extension and flexion, as measured by dynamometer.

	Introduction

Top Abstract Introduction Subjects and Methods Results Discussion References

 
AS MEN AGE, their serum testosterone concentrations decrease. Cross-sectional studies show that at age 80 yr the total serum testosterone concentration is approximately 75%, and the free testosterone concentration is approximately 50% of that at age 20 yr (1, 2). A longitudinal study that followed a cohort of men for 15 yr also showed a decrease in serum testosterone concentration with age (3).

One possible consequence of this decrease in testosterone with increasing age is a change in body composition and a decrease in muscle strength. As men age, lean mass decreases, and fat mass increases (4). Similar changes occur in men whose serum testosterone is low because of pituitary or testicular disease; when they are treated with testosterone, lean mass increases, and fat mass decreases (5). Also as men age, their muscle strength decreases (6). In one study in hypogonadal men, testosterone treatment was associated with an increase in muscle strength (7).

Because of the similarities between the changes that occur when men age and those that occur when they become hypogonadal as the consequence of known pituitary or testicular disease, we hypothesized that increasing the serum testosterone concentrations of elderly men to those found in young men would decrease their fat mass, increase their lean mass, and increase their muscle strength. We tested this hypothesis by selecting healthy men over 65 yr of age, assigning them randomly to receive either testosterone or placebo, and measuring body composition and muscle strength repeatedly during 3 yr of treatment.

	Subjects and Methods

Top Abstract Introduction Subjects and Methods Results Discussion References

 
Subjects

We recruited men over 65 yr of age by mailings to alumni of the University of Pennsylvania and Temple University and by appeals via television and newspaper. From those who responded, we included men whose serum testosterone concentration was 1 SD or more below the mean for normal young men (<475 ng/dL). We excluded men who had diseases or were taking medications known to cause hypogonadism and men who had conditions that would affect muscle strength, such as a history of cerebrovascular accident. We also excluded men who had diseases that testosterone could exacerbate, such as prostate cancer and severe benign prostatic hypertrophy. One hundred and eight men met the criteria and enrolled after giving informed consent to a protocol approved by the University of Pennsylvania committee on studies involving humans.

Study design

Subjects were randomized to receive either testosterone or placebo in a double blind fashion. The subjects’ treatment assignments were known only to the data manager, research pharmacist, and safety-monitoring board until the last subject completed the entire 36 months of the study. Testosterone was administered by a scrotal patch (Testoderm, Alza Corp., Palo Alto, CA); placebo patches were identical in appearance to the testosterone patches. Each subject was asked to use a patch that delivers 6 mg/day initially, to wear it at all times except when bathing, to change the patch once a day, and to shave the scrotum once a week. The serum testosterone concentration was measured and reviewed in a blinded fashion every 3 months. The data manager directed that the dose be decreased to 4 mg/day if the serum testosterone concentration was more than 1000 ng/dL (34.7 nmol/L) and that the subject be reeducated in patch technique if the concentration was less than 250 ng/dL (8.7 nmol/L) above the pretreatment concentration. To maintain the blinding, the data manager directed in each case of change of dose that a subject in the placebo group be treated similarly.

Body composition

Body composition was determined by dual energy x-ray absorptiometry (8) using a DPX scanner (Lunar Corp., Madison, WI) with acquisition software versions 3.1–3.61 and body composition software version 1.3. Results included total mass, fat mass, and lean (fat-free) mass, each for total body, arms, legs, and trunk.

Muscle strength

Hand grip strength was measured by a Jaymar dynamometer (Sal-mon Preston, Boling Brook, IL). Subjects were coached orally to exert maximum effort during three trials, each separated by a 2-min rest. The maximum result was used for analysis.

The strength of knee extension and flexion was measured by Biodex dynamometer (Biodox Corporation, Shirley, NY). Before the measurements the subjects warmed up by using a stationary bicycle at low resistance for 5 min and then by two trials on the Biodex using submaximal effort and two trials using maximal effort. With the instrument set for 60° angular velocity, the subject was asked to extend the knee with maximal effort and then flex passively and repeat this maneuver twice after 15–20 s of rest. The procedure was repeated three times, with maximal effort flexing the knee and passive extension. The entire procedure was repeated with instrument set for 180° of angular velocity. The maximum value for extension and flexion at 60° and 180° of angular velocity was used for analysis.

Physical function

Physical function was assessed by walking and stair climbing. The time and the number of steps required for a subject to walk 25 ft at his usual pace was recorded. The time for the subject to climb 12 stairs was also recorded.

Questionnaires

Two questionnaires were used. One was the Medical Outcomes Study Short-Form-36 (MOS SF-36) (9), a generic health-related quality of life questionnaire that assesses eight areas, including physical functioning, role limitations because of health problems, bodily pain, social functioning, mental health, role limitations due to emotional problems, vitality, and general health perceptions. Each questionnaire was scored, and the raw scores were transformed to a 0–100 scale by computer. The second questionnaire, designed for this study, consisted of eight questions, four about general sense of energy and four about sexual function. Scores were also 0–100. For each test, the four energy scores were averaged, and the four sexual function scores were averaged.

Statistical analyses

Analyses were performed using the intent to treat approach, so the last observation of each of the 12 men who did not complete the entire 36 months of treatment was carried forward to all subsequent time points. Within each group, the significance of the change from 0–36 months was tested using paired t test. Between groups, the principal test was the independent sample t test comparing the mean change from 0–36 months between the 2 treatment groups. We confirmed the results of this analysis using an analysis of covariance, comparing the final values adjusted for the pretreatment values, and by the Wilcoxon signed rank test. Because these 3 tests gave similar results, only the results of the comparisons of the differences are presented. Linear regression (10) was used to determine whether the effect of testosterone treatment depended on the pretreatment serum testosterone concentration.

	Results

Top Abstract Introduction Subjects and Methods Results Discussion References

 
Of the 108 men who were randomized to receive either testosterone or placebo, 96 completed the entire 3 yr of the protocol. Of the 12 who discontinued, 1 (placebo group) was asked to because he was found to have a history of prostate cancer that he had concealed, 1 (testosterone group) developed prostate cancer, 2 died (both in the placebo group), and 8 (5 in the placebo group and 3 in the testosterone group) discontinued for personal reasons.

The mean serum testosterone concentration during the 36 months of the study did not change in the placebo-treated men. The mean serum testosterone concentration in the testosterone-treated group increased from 367 ± 79 ng/dL (±SD; 12.7 ± 2.7 nmol/L) before treatment to 625 ± 249 ng/dL (21.7 ± 8.6 nmol/L; P < 0.001) by the sixth month of treatment and remained at that level for the duration of the treatment period (11). The mean serum free testosterone concentration increased similarly. The effects of this treatment on bone mineral density and prostate and hematological parameters have been reported previously (11).

Body composition

The two groups of subjects had similar weight, body mass index, tissue mass, fat mass, and lean mass before treatment (Table 1). During the 36 months of treatment, the testosterone-treated subjects experienced a significant decrease in fat mass (-2.9 ± 0.5 kg) and an increase in lean mass (1.9 ± 0.3 kg), whereas the placebo-treated subjects did not experience a significant change in either (Table 1 and Fig. 1). The changes from 0–36 months differed significantly between the two groups for both fat mass (P = 0.001) and lean mass (P < 0.001). Linear regression analyses indicated that the effects of testosterone treatment on fat mass and lean mass varied inversely and significantly (P < 0.02) as a function of the pretreatment serum testosterone concentration, but not as a function of the increment in serum testosterone concentration during treatment.

View larger version (16K): [in this window] [in a new window]   Figure 1. Mean (±SE) change from baseline in total body mass, fat mass, and lean mass, as determined by dual energy x-ray absorptiometry, in 108 men over 65 yr of age who were treated with either testosterone or placebo (54 men each). The decrease in fat mass (P < 0.005) and the increase in lean mass (P < 0.001) in the testosterone-treated subjects were significantly different from those in the placebo-treated subjects at 36 months.

View larger version (33K): [in this window] [in a new window]   Figure 2. Mean (±SE) change from baseline in the fat and lean mass of the arms, legs, and trunk, as determined by dual energy x-ray absorptiometry, of 108 men over 65 yr of age who were treated with either testosterone or placebo (54 men each). The decrease in fat mass in the arms (P < 0.02) and legs (P < 0.001) and the increase in lean mass of the trunk (P < 0.001) in the testosterone-treated subjects were significantly different from those in the placebo-treated subjects at 36 months. Other changes were not significantly different between the 2 groups.

Muscle strength

The strength of knee extension at 60° and 180° of angular velocity was similar in both groups before treatment and decreased significantly (P < 0.001) in both groups during the course of 36 months of treatment, but the changes during treatment did not differ between the groups (Table 2). The strength of knee flexion at 60° and 180° of angular velocity did not differ between the two groups before or after treatment (Table 2). Hand grip strength did not differ between the two groups before or after treatment (Table 2).

Changes in tests of physical function, including time to walk 25 ft, number of steps taken in walking 25 ft, and time to climb 12 stairs, did not differ between the 2 groups before or after treatment (Table 2).

Questionnaires

The perception of physical functioning, one of the eight parameters assessed by the MOS SF-36 questionnaire, decreased significantly (P < 0.001) in the placebo-treated group during the 36 months of treatment, but not in the testosterone-treated group. Perception of physical functioning in the testosterone-treated group was significantly greater (P < 0.05) in the testosterone-treated group than in the placebo-treated group at the end of the 36 months, when corrected for baseline values (Table 3 and Fig. 3). Linear regression analysis indicated that the effect of testosterone treatment on perception of physical functioning varied inversely and significantly (P < 0.01) as a function of the pretreatment serum testosterone concentration. The lower the pretreatment serum testosterone concentration, the greater the testosterone treatment effect on perception of physical function (Fig. 3). For a pretreatment serum testosterone concentration of 400 ng/dL, the effect of testosterone treatment was only 8.2 ± 3.8%, but for a pretreatment serum testosterone concentration of 200 ng/dL, the effect of testosterone treatment was 30.2 ± 8.3% (P < 0.005).

View larger version (23K): [in this window] [in a new window]   Figure 3. Upper panel, Mean (±SE) change from baseline perception of physical function, as determined by the MOS SF-36 questionnaire, in 108 men over 65 yr of age who were treated with either testosterone or placebo (54 men each). The difference between the testosterone- and placebo-treated men at 36 months was significant (P < 0.02). Lower panel, The effect of testosterone treatment on percent change in perception of physical function during 36 months of testosterone treatment of men over 65 yr of age as a function of the pretreatment serum testosterone concentration. The lower the pretreatment serum testosterone concentration, the greater the effect of testosterone treatment on perception of physical function. The testosterone treatment effect was statistically significant overall at P < 0.01 and for testosterone concentrations of 100–300 ng/dL at P < 0.005. To convert testosterone values to nanomoles per L, multiply by 0.03467.

	Discussion

Top Abstract Introduction Subjects and Methods Results Discussion References

 
Increasing the serum testosterone concentration of healthy elderly men to that of young men increased their lean mass, especially of the trunk, and decreased their fat mass, especially of the arms and legs, but did not increase their strength of knee extension or flexion. Testosterone treatment also increased the subjects’ self-perception of physical function, but not objective tests of physical function.

The overall effects of testosterone on body composition observed in this study are similar to the effects of testosterone on body composition in men who have frank hypogonadism due to known causes. In a study of 6 previously healthy men who were made severely hypogonadal by the administration of leuprolide, percent fat mass, as measured by dual energy x-ray absorptiometry, increased, and fat-free mass decreased (12). In a study of 13 previously untreated hypogonadal men who were treated with 100 mg testosterone enanthate or cypionate once a week for 18 months, total body fat, as measured by quantitative computed tomography, decreased significantly (5). In another study, testosterone replacement was discontinued in 7 hypogonadal men for at least 12 weeks before they were tested. They were then treated with 100 mg testosterone enanthate once a week and tested again 10 weeks later. Testosterone treatment did not decrease the percent fat, but did increase the fat-free mass, as determined by underwater weighing (7). In a study of men who had acquired immunodeficiency syndrome wasting and had relatively low serum testosterone concentrations, transdermal testosterone treatment for 12 weeks decreased fat mass and increased lean mass (13). In another study of men with acquired immunodeficiency syndrome wasting and hypogonadism, treatment with 300 mg testosterone enanthate every 3 weeks for 6 months increased fat-free mass, but did not decrease fat mass (14). The overall effects of testosterone on body composition observed in this study are also similar to those seen in studies of older men treated with mildly pharmacological doses of testosterone (15, 16, 17).

Even though the reproducibility of regional body composition measurements by dual energy x-ray absortiometry, especially of fat tissue, is less than that of total body composition (18), clear changes in regional body composition occurred in this study. The finding that testosterone decreased fat mass in the arms and legs suggests that its effect in those locations may have been on sc fat. This effect is similar to that observed in the 13 hypogonadal men, described above, in whom testosterone treatment clearly decreased sc fat, but only marginally decreased intraabdominal and visceral fat (5). The clinical significance of testosterone decreasing arm and leg fat is not at all clear. Although visceral fat has been associated with risk factors for cardiovascular disease and even clinical cardiovascular disease, sc fat of the arms and legs has not been so closely correlated. In a study of 58 obese men, visceral adipose tissue, as measured by computed tomography, was positively correlated with plasma glucose and insulin concentrations after an oral glucose load and was negatively correlated with serum high density lipoprotein cholesterol concentration (19). Subcutaneous abdominal adipose tissue, however, was not independently correlated with these indexes of carbohydrate and lipoprotein metabolism, and femoral adipose tissue was not at all correlated. In a prospective study of 6718 men without a history of clinical coronary heart disease, 212 men developed coronary events during a subsequent mean observation period of 6.6 yr. Mean skinfold thickness at the time of initial examination in the men who eventually developed new coronary events was significantly greater than that in the men who did not develop coronary events at all 5 sites in the trunk, but in only 3 of 4 sites in the arm and in none of 4 sites in the thigh (20).

The finding that testosterone increased lean mass principally in the trunk is difficult to explain. The anatomical site of the increase, whether in the large muscles of the upper chest and back or other tissues, cannot be determined from these data.

The lack of an effect of testosterone on strength of knee extension does not support the principal hypothesis of the study and runs counter to conventional wisdom about the effect of testosterone. One possible explanation for the lack of an effect is that the pretreatment serum testosterone concentration was not sufficiently low, but this explanation seems unlikely, because linear regression analysis showed no relationship between the testosterone treatment effect on muscle strength and the pretreatment serum testosterone concentration. Another possible explanation is that the increase in the serum testosterone concentration during treatment was not sufficiently great, but this explanation seems unlikely, because the serum testosterone concentration increased by a mean of more than 250 ng/dL in the testosterone-treated subjects, so that their mean serum testosterone concentration was in the midnormal range for young men. Another possible explanation is that the tests of muscle strength employed were not the optimal tests to detect changes in muscle strength. In the study described above in seven frankly hypogonadal men in whom testosterone, administered in a nonblinded fashion, increased muscle strength by 22%, muscle strength was assessed by a bench press instrument (7), whereas in the present study, strength was assessed by dynamometer. In three studies in which older men were treated with mildly pharmacological doses of testosterone, muscle strength increased in two (17, 21) but not in the third (15). In view of the lack of a significant increase in lean mass in the arms and legs in response to testosterone treatment in the elderly men in the present study, however, perhaps it is not surprising that there was no significant effect of testosterone on muscle strength.

Testosterone treatment did significantly increase the subjects’ self-perception of their physical function, and it did so in inverse relationship to their pretreatment serum testosterone concentration. Testosterone did not, however, increase measured physical function. We cannot explain this discrepancy.

We conclude that raising the serum testosterone concentration of healthy elderly men to that of young men changed their body composition, in that it increased their lean mass and decreased their fat mass, principally in the arms and legs. The increase in serum testosterone concentration, however, did not increase the measured strength of knee extension or flexion. Body composition is now the second parameter in this study [bone mineral density of the spine was the first (11)], in which testosterone treatment of elderly men with low serum testosterone concentrations has been shown to be efficacious. Although prostate and hematological parameters were monitored, and no statistically significant changes occurred (11), the study was not designed to have sufficient statistical power to evaluate these effects, so we cannot draw definite conclusions about the risk of administering testosterone to men over 65 yr of age.

	Acknowledgments

 
We thank the study subjects for their conscientiousness, Dr. Linda Atkinson of Alza Corp. for providing Testoderm, Dr. Curtis Slipman for advice about muscle strength testing, Drs. Babette Zemel and Virginia Stallings for advice about body composition analysis, and Dr. Kenneth Rockwell for distribution of the testosterone patches.

	Footnotes

 
¹ This work was supported by NIH Grants AR-41425 and AG-10954 (to P.J.S.) and RR-040 (to the General Clinical Research Center of the University of Pennsylvania).

Received March 11, 1999.

Revised April 14, 1999.

Accepted April 26, 1999.

	References

Top Abstract Introduction Subjects and Methods Results Discussion References

 

1. Purifoy FE, Koopmans LH, Mayes DM. 1981 Age differences in serum androgen levels in normal adult males. Hum Biol. 53:499–511.[Medline]
2. Deslypere JP, Vermeulen A. 1984 Leydig cell function in normal men: effect of age, life-style, residence, diet, and activity. J Clin Endocrinol Metab. 59:955–962.[Abstract/Free Full Text]
3. Morley JE, Kaiser FE, Perry III HM, et al. 1997. Longitudinal changes in testosterone, luteinizing hormone, and follicle stimulating hormone in healthy older men. Metab Clin Exp. 46:410–413.
4. Forbes GB, Reina JC. 1970 Adult lean body mass declines with age: some longitudinal observations. Metabolism. 19:653–663.[CrossRef][Medline]
5. Katznelson L, Finkelstein JS, Schoenfeld DS, Rosenthal DI, Anderson EJ, Klibanski A. 1996 Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism. J Clin Endocrinol Metab. 81:4358–4365.[Abstract]
6. Murray MP, Gardner GM, Mollinger LA, Sepic SB. 1979 Strength of isometric and isokinetic contractions. Phys Ther. 60:412–723.
7. Bhasin S, Storer TW, Berman N, et al. 1997 Testosterone replacement increases fat-free mass and muscle size in hypogonadal men. J Clin Endocrinol Metab. 82:407–413.[Abstract/Free Full Text]
8. Heymsfield SB, Wang Z, Baumgartner RN, Ross R. 1997 Human body composition: advances in models and methods. Annu Rev Nutr. 17:527–558.[CrossRef][Medline]
9. Ware Jr JE, Sherbourne CD. 1992 The MOS 36-item short-form health survey. Med Care. 30:473–483.[Medline]
10. Neter J, Wasserman W, Kutner MH. 1990 Applied linear statistical models: regression, analysis of variance, and experimental designs. Homewood: Irwin.
11. Snyder PJ, Peachey H, Hannoush P, et al. 1999 Effect of testosterone treatment on bone mineral density in men over 65. J Clin Endocrinol Metab. 84:1966–1972.[Abstract/Free Full Text]
12. Mauras N, Hayes V, Welch S, et al. 1998 Testosterone deficiency in young men: marked alterations in whole body protein kinetics, strength, and adiposity. J Clin Endocrinol Metab. 83:1886–1892.[Abstract/Free Full Text]
13. Bhasin S, Storer TW, Asbel-Sethi N, et al. 1998 Effects of testosterone replacement with a nongenital, transdermal system, androderm, in human immunodeficiency virus infected men with low testosterone levels. J Clin Endocrinol Metab. 83:3155–3162.[Abstract/Free Full Text]
14. Grinspoon S, Corcoran C, Askari H, et al. 1998 Effects of androgen administration in men with the aids wasting syndrome. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 129:18–26.[Abstract/Free Full Text]
15. Tenover JS. 1992 Effects of testosterone supplementation in the aging male. J Clin Endocrinol Metab. 75:1092–1098.[Abstract]
16. Brodsky IG, Galagopal P, Nair KS. 1996 Effects of testosterone replacement on muscle mass and muscle protein synthesis in hypogonadal men–a clinical research center study. J Clin Endocrinol Metab. 81:3469–3475.[Abstract]
17. Sih R, Morley JE, Kaiser FE, Perry HM III, Patrick P, Ross C. 1997 Testosterone replacement in older hypogonadal men: a 12-month randomized controlled trial. J Clin Endocrinol Metab. 82:1661–1667.[Abstract/Free Full Text]
18. Mazess RB, Barden HS, Bisek JP, Hanson J. 1990 Dual-energy x-ray absorptiometry for total-body and regional bone-mineral and soft-tissue composi-tion. Am J Clin Nutr. 51:1106–1112.[Abstract/Free Full Text]
19. Pouliot MC, Despres JP, Nadeau A, et al. 1992 Visceral obesity in men. Associations with glucose tolerance, plasma insulin, and lipoprotein levels. Diabetes. 41:826–834.[Abstract]
20. Ducimetiere P, Richard J, Cambien F. 1986 The pattern of subcutaneous fat distribution in middle-aged men and the risk of coronary heart disease: the Paris prospective study. Int J Obes. 10:229–240.[Medline]
21. Urban RJ, Bodenburg YH, Gilkison C, Foxworth J, Coggan AR, Wolfe RR, Ferando A. 1995 Testosterone administration to elderly men increases skeletal muscle strength and protein synthesis. Am J Physiol 269:E820–E826.

This article has been cited by other articles:

				F. Laghi, N. Adiguzel, and M. J. Tobin Endocrinological derangements in COPD Eur. Respir. J., October 1, 2009; 34(4): 975 - 996. [Abstract] [Full Text] [PDF]

				C. Koutsari, A. H. Ali, K. S. Nair, R. A. Rizza, P. O'Brien, S. Khosla, and M. D. Jensen Fatty Acid Metabolism in the Elderly: Effects of Dehydroepiandrosterone and Testosterone Replacement in Hormonally Deficient Men and Women J. Clin. Endocrinol. Metab., September 1, 2009; 94(9): 3414 - 3423. [Abstract] [Full Text] [PDF]

				J. Ophoff, K. Van Proeyen, F. Callewaert, K. De Gendt, K. De Bock, A. Vanden Bosch, G. Verhoeven, P. Hespel, and D. Vanderschueren Androgen Signaling in Myocytes Contributes to the Maintenance of Muscle Mass and Fiber Type Regulation But Not to Muscle Strength or Fatigue Endocrinology, August 1, 2009; 150(8): 3558 - 3566. [Abstract] [Full Text] [PDF]

				F. R. Sattler, C. Castaneda-Sceppa, E. F. Binder, E. T. Schroeder, Y. Wang, S. Bhasin, M. Kawakubo, Y. Stewart, K. E. Yarasheski, J. Ulloor, et al. Testosterone and Growth Hormone Improve Body Composition and Muscle Performance in Older Men J. Clin. Endocrinol. Metab., June 1, 2009; 94(6): 1991 - 2001. [Abstract] [Full Text] [PDF]

				J.-J. Legros, E. J H Meuleman, J. M H Elbers, T B P. Geurts, M. J G H Kaspers, P. M G Bouloux, and for the Study 43203 Investigators Oral testosterone replacement in symptomatic late-onset hypogonadism: effects on rating scales and general safety in a randomized, placebo-controlled study Eur. J. Endocrinol., May 1, 2009; 160(5): 821 - 831. [Abstract] [Full Text] [PDF]

				T. A C M van Geel, P. P Geusens, B. Winkens, J.-P. J E Sels, and G.-J. Dinant Measures of bioavailable serum testosterone and estradiol and their relationships with muscle mass, muscle strength and bone mineral density in postmenopausal women: a cross-sectional study Eur. J. Endocrinol., April 1, 2009; 160(4): 681 - 687. [Abstract] [Full Text] [PDF]

				I. M Chapman, R. Visvanathan, A. J Hammond, J. E Morley, J. B. Field, K. Tai, D. P Belobrajdic, R. Y. Chen, and M. Horowitz Effect of testosterone and a nutritional supplement, alone and in combination, on hospital admissions in undernourished older men and women Am. J. Clinical Nutrition, March 1, 2009; 89(3): 880 - 889. [Abstract] [Full Text] [PDF]

				R. Singh, S. Bhasin, M. Braga, J. N. Artaza, S. Pervin, W. E. Taylor, V. Krishnan, S. K. Sinha, T. B. Rajavashisth, and R. Jasuja Regulation of Myogenic Differentiation by Androgens: Cross Talk between Androgen Receptor/ {beta}-Catenin and Follistatin/Transforming Growth Factor-{beta} Signaling Pathways Endocrinology, March 1, 2009; 150(3): 1259 - 1268. [Abstract] [Full Text] [PDF]

				G. C. Henderson, K. Dhatariya, G. C. Ford, K. A. Klaus, R. Basu, R. A. Rizza, M. D. Jensen, S. Khosla, P. O'Brien, and K. S. Nair Higher muscle protein synthesis in women than men across the lifespan, and failure of androgen administration to amend age-related decrements FASEB J, February 1, 2009; 23(2): 631 - 641. [Abstract] [Full Text] [PDF]

				C. Wang, E. Nieschlag, R. Swerdloff, H. M. Behre, W. J. Hellstrom, L. J. Gooren, J. M. Kaufman, J.-J. Legros, B. Lunenfeld, A. Morales, et al. Investigation, Treatment, and Monitoring of Late-Onset Hypogonadism in Males: ISA, ISSAM, EAU, EAA, and ASA Recommendations J Androl, January 1, 2009; 30(1): 1 - 9. [Full Text] [PDF]

				G. L. Jensen Inflammation: Roles in Aging and Sarcopenia JPEN J Parenter Enteral Nutr, November 1, 2008; 32(6): 656 - 659. [Abstract] [Full Text] [PDF]

				C Wang, E Nieschlag, R Swerdloff, H M Behre, W J Hellstrom, L J Gooren, J M Kaufman, J-J Legros, B Lunenfeld, A Morales, et al. Investigation, treatment and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA and ASA recommendations Eur. J. Endocrinol., November 1, 2008; 159(5): 507 - 514. [Full Text] [PDF]

				V. Kupelian, F. J. Hayes, C. L. Link, R. Rosen, and J. B. McKinlay Inverse Association of Testosterone and the Metabolic Syndrome in Men Is Consistent across Race and Ethnic Groups J. Clin. Endocrinol. Metab., September 1, 2008; 93(9): 3403 - 3410. [Abstract] [Full Text] [PDF]

				M. G. Giannoulis, N. Jackson, F. Shojaee-Moradie, K. S. Nair, P. H. Sonksen, F. C. Martin, and A. M. Umpleby The Effects of Growth Hormone and/or Testosterone on Whole Body Protein Kinetics and Skeletal Muscle Gene Expression in Healthy Elderly Men: A Randomized Controlled Trial J. Clin. Endocrinol. Metab., August 1, 2008; 93(8): 3066 - 3074. [Abstract] [Full Text] [PDF]

				E. Barrett-Connor, T.-T. Dam, K. Stone, S. L. Harrison, S. Redline, E. Orwoll, and for the Osteoporotic Fractures in Men Study Group The Association of Testosterone Levels with Overall Sleep Quality, Sleep Architecture, and Sleep-Disordered Breathing J. Clin. Endocrinol. Metab., July 1, 2008; 93(7): 2602 - 2609. [Abstract] [Full Text] [PDF]

				D. Paddon-Jones, K. R Short, W. W Campbell, E. Volpi, and R. R Wolfe Role of dietary protein in the sarcopenia of aging Am. J. Clinical Nutrition, May 1, 2008; 87(5): 1562S - 1566S. [Abstract] [Full Text] [PDF]

				M. H. Emmelot-Vonk, H. J. J. Verhaar, H. R. Nakhai Pour, A. Aleman, T. M. T. W. Lock, J. L. H. R. Bosch, D. E. Grobbee, and Y. T. van der Schouw Effect of Testosterone Supplementation on Functional Mobility, Cognition, and Other Parameters in Older Men: A Randomized Controlled Trial JAMA, January 2, 2008; 299(1): 39 - 52. [Abstract] [Full Text] [PDF]

				P. J. Snyder Might Testosterone Actually Reduce Mortality? J. Clin. Endocrinol. Metab., January 1, 2008; 93(1): 32 - 33. [Full Text] [PDF]

				C. A. Allan, B. J. G. Strauss, H. G. Burger, E. A. Forbes, and R. I. McLachlan Testosterone Therapy Prevents Gain in Visceral Adipose Tissue and Loss of Skeletal Muscle in Nonobese Aging Men J. Clin. Endocrinol. Metab., January 1, 2008; 93(1): 139 - 146. [Abstract] [Full Text] [PDF]

				S. Basaria and A. S. Dobs Testosterone Making an Entry Into the Cardiometabolic World Circulation, December 4, 2007; 116(23): 2658 - 2661. [Full Text] [PDF]

				M. Zitzmann and E. Nieschlag Androgen Receptor Gene CAG Repeat Length and Body Mass Index Modulate the Safety of Long-Term Intramuscular Testosterone Undecanoate Therapy in Hypogonadal Men J. Clin. Endocrinol. Metab., October 1, 2007; 92(10): 3844 - 3853. [Abstract] [Full Text] [PDF]

				D. M. Greenfield, S. J. Walters, R. E. Coleman, B. W. Hancock, R. Eastell, H. A. Davies, J. A. Snowden, L. Derogatis, S. M. Shalet, and R. J. M. Ross Prevalence and Consequences of Androgen Deficiency in Young Male Cancer Survivors in a Controlled Cross-Sectional Study J. Clin. Endocrinol. Metab., September 1, 2007; 92(9): 3476 - 3482. [Abstract] [Full Text] [PDF]

				S. T. Page, A. M. Matsumoto, W. J. Bremner, M. Yasuda, S. Horie, T. T. Perls, N. Gleicher, D. Barad, K. S. Nair, and G. Smith DHEA and Testosterone in the Elderly N. Engl. J. Med., February 8, 2007; 356(6): 635 - 637. [Full Text] [PDF]

				P. B. Rapuri, J. C. Gallagher, and L. M. Smith Smoking Is a Risk Factor for Decreased Physical Performance in Elderly Women J. Gerontol. A Biol. Sci. Med. Sci., January 1, 2007; 62(1): 93 - 99. [Abstract] [Full Text] [PDF]

				J. Ostrowski, J. E. Kuhns, J. A. Lupisella, M. C. Manfredi, B. C. Beehler, S. R. Krystek Jr., Y. Bi, C. Sun, R. Seethala, R. Golla, et al. Pharmacological and X-Ray Structural Characterization of a Novel Selective Androgen Receptor Modulator: Potent Hyperanabolic Stimulation of Skeletal Muscle with Hypostimulation of Prostate in Rats Endocrinology, January 1, 2007; 148(1): 4 - 12. [Abstract] [Full Text] [PDF]

				L. Katznelson, M. W Robinson, C. L Coyle, H. Lee, and C. E Farrell Effects of modest testosterone supplementation and exercise for 12 weeks on body composition and quality of life in elderly men Eur. J. Endocrinol., December 1, 2006; 155(6): 867 - 875. [Abstract] [Full Text] [PDF]

				E. Orwoll, L. C. Lambert, L. M. Marshall, J. Blank, E. Barrett-Connor, J. Cauley, K. Ensrud, S. R. Cummings, and for the Osteoporotic Fractures in Men Study Group Endogenous testosterone levels, physical performance, and fall risk in older men. Arch Intern Med, October 23, 2006; 166(19): 2124 - 2131. [Abstract] [Full Text] [PDF]

				K. S. Nair, R. A. Rizza, P. O'Brien, K. Dhatariya, K. R. Short, A. Nehra, J. L. Vittone, G. G. Klee, A. Basu, R. Basu, et al. DHEA in Elderly Women and DHEA or Testosterone in Elderly Men N. Engl. J. Med., October 19, 2006; 355(16): 1647 - 1659. [Abstract] [Full Text] [PDF]

				A.-M. Axell, H. E. MacLean, D. R. Plant, L. J. Harcourt, J. A. Davis, M. Jimenez, D. J. Handelsman, G. S. Lynch, and J. D. Zajac Continuous testosterone administration prevents skeletal muscle atrophy and enhances resistance to fatigue in orchidectomized male mice Am J Physiol Endocrinol Metab, September 1, 2006; 291(3): E506 - E516. [Abstract] [Full Text] [PDF]

				I. Sinha-Hikim, M. Cornford, H. Gaytan, M. L. Lee, and S. Bhasin Effects of Testosterone Supplementation on Skeletal Muscle Fiber Hypertrophy and Satellite Cells in Community-Dwelling Older Men J. Clin. Endocrinol. Metab., August 1, 2006; 91(8): 3024 - 3033. [Abstract] [Full Text] [PDF]

				J J Corrales, M Almeida, R Burgo, M T Mories, J M Miralles, and A Orfao Androgen-replacement therapy depresses the ex vivo production of inflammatory cytokines by circulating antigen-presenting cells in aging type-2 diabetic men with partial androgen deficiency. J. Endocrinol., June 1, 2006; 189(3): 595 - 604. [Abstract] [Full Text] [PDF]

				S. Bhasin, G. R. Cunningham, F. J. Hayes, A. M. Matsumoto, P. J. Snyder, R. S. Swerdloff, and V. M. Montori Testosterone Therapy in Adult Men with Androgen Deficiency Syndromes: An Endocrine Society Clinical Practice Guideline J. Clin. Endocrinol. Metab., June 1, 2006; 91(6): 1995 - 2010. [Abstract] [Full Text] [PDF]

				E. L. Ding, Y. Song, V. S. Malik, and S. Liu Sex Differences of Endogenous Sex Hormones and Risk of Type 2 Diabetes: A Systematic Review and Meta-analysis JAMA, March 15, 2006; 295(11): 1288 - 1299. [Abstract] [Full Text] [PDF]

				M. G. Giannoulis, P. H. Sonksen, M. Umpleby, L. Breen, C. Pentecost, M. Whyte, C. V. McMillan, C. Bradley, and F. C. Martin The Effects of Growth Hormone and/or Testosterone in Healthy Elderly Men: A Randomized Controlled Trial J. Clin. Endocrinol. Metab., February 1, 2006; 91(2): 477 - 484. [Abstract] [Full Text] [PDF]

				A. B. O'Donnell, T. G. Travison, S. S. Harris, J. L. Tenover, and J. B. McKinlay Testosterone, Dehydroepiandrosterone, and Physical Performance in Older Men: Results from the Massachusetts Male Aging Study J. Clin. Endocrinol. Metab., February 1, 2006; 91(2): 425 - 431. [Abstract] [Full Text] [PDF]

				R. Singh, J. N. Artaza, W. E. Taylor, M. Braga, X. Yuan, N. F. Gonzalez-Cadavid, and S. Bhasin Testosterone Inhibits Adipogenic Differentiation in 3T3-L1 Cells: Nuclear Translocation of Androgen Receptor Complex with {beta}-Catenin and T-Cell Factor 4 May Bypass Canonical Wnt Signaling to Down-Regulate Adipogenic Transcription Factors Endocrinology, January 1, 2006; 147(1): 141 - 154. [Abstract] [Full Text] [PDF]

				E. T. Schroeder, A. F. Vallejo, L. Zheng, Y. Stewart, C. Flores, S. Nakao, C. Martinez, and F. R. Sattler Six-Week Improvements in Muscle Mass and Strength During Androgen Therapy in Older Men J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2005; 60(12): 1586 - 1592. [Abstract] [Full Text] [PDF]

				O. M. Calof, A. B. Singh, M. L. Lee, A. M. Kenny, R. J. Urban, J. L. Tenover, and S. Bhasin Adverse Events Associated With Testosterone Replacement in Middle-Aged and Older Men: A Meta-Analysis of Randomized, Placebo-Controlled Trials J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2005; 60(11): 1451 - 1457. [Abstract] [Full Text] [PDF]

				W. Gao, P. J. Reiser, C. C. Coss, M. A. Phelps, J. D. Kearbey, D. D. Miller, and J. T. Dalton Selective Androgen Receptor Modulator Treatment Improves Muscle Strength and Body Composition and Prevents Bone Loss in Orchidectomized Rats Endocrinology, November 1, 2005; 146(11): 4887 - 4897. [Abstract] [Full Text] [PDF]

				J. M. Kaufman and A. Vermeulen The Decline of Androgen Levels in Elderly Men and Its Clinical and Therapeutic Implications Endocr. Rev., October 1, 2005; 26(6): 833 - 876. [Abstract] [Full Text] [PDF]

				P. Y. Takahashi, P. Y. Liu, P. D. Roebuck, A. Iranmanesh, and J. D. Veldhuis Graded Inhibition of Pulsatile Luteinizing Hormone Secretion by a Selective Gonadotropin-Releasing Hormone (GnRH)-Receptor Antagonist in Healthy Men: Evidence That Age Attenuates Hypothalamic GnRH Outflow J. Clin. Endocrinol. Metab., May 1, 2005; 90(5): 2768 - 2774. [Abstract] [Full Text] [PDF]

				F. Laghi, W. E. Langbein, A. Antonescu-Turcu, A. Jubran, C. Bammert, and M. J. Tobin Respiratory and Skeletal Muscles in Hypogonadal Men with Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., March 15, 2005; 171(6): 598 - 605. [Abstract] [Full Text] [PDF]

				S. T. Page, J. K. Amory, F. D. Bowman, B. D. Anawalt, A. M. Matsumoto, W. J. Bremner, and J. L. Tenover Exogenous Testosterone (T) Alone or with Finasteride Increases Physical Performance, Grip Strength, and Lean Body Mass in Older Men with Low Serum T J. Clin. Endocrinol. Metab., March 1, 2005; 90(3): 1502 - 1510. [Abstract] [Full Text] [PDF]

				S. Bhasin, L. Woodhouse, R. Casaburi, A. B. Singh, R. P. Mac, M. Lee, K. E. Yarasheski, I. Sinha-Hikim, C. Dzekov, J. Dzekov, et al. Older Men Are as Responsive as Young Men to the Anabolic Effects of Graded Doses of Testosterone on the Skeletal Muscle J. Clin. Endocrinol. Metab., February 1, 2005; 90(2): 678 - 688. [Abstract] [Full Text] [PDF]

				J. D. Veldhuis, J. N. Roemmich, E. J. Richmond, A. D. Rogol, J. C. Lovejoy, M. Sheffield-Moore, N. Mauras, and C. Y. Bowers Endocrine Control of Body Composition in Infancy, Childhood, and Puberty Endocr. Rev., February 1, 2005; 26(1): 114 - 146. [Abstract] [Full Text] [PDF]

				P. Y. Liu, S. M. Pincus, D. M. Keenan, F. Roelfsema, and J. D. Veldhuis Analysis of bidirectional pattern synchrony of concentration-secretion pairs: implementation in the human testicular and adrenal axes Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2005; 288(2): R440 - R446. [Abstract] [Full Text] [PDF]

				P. Y. Liu, R. S. Swerdloff, and J. D. Veldhuis The Rationale, Efficacy and Safety of Androgen Therapy in Older Men: Future Research and Current Practice Recommendations J. Clin. Endocrinol. Metab., October 1, 2004; 89(10): 4789 - 4796. [Abstract] [Full Text] [PDF]

				E. T. Schroeder, L. Zheng, M. D. Ong, C. Martinez, C. Flores, Y. Stewart, C. Azen, and F. R. Sattler Effects of Androgen Therapy on Adipose Tissue and Metabolism in Older Men J. Clin. Endocrinol. Metab., October 1, 2004; 89(10): 4863 - 4872. [Abstract] [Full Text] [PDF]

				E. Nieschlag, H.M. Behre, P. Bouchard, J.J. Corrales, T.H. Jones, G.K. Stalla, S.M. Webb, and F.C.W. Wu Testosterone replacement therapy: current trends and future directions Hum. Reprod. Update, September 1, 2004; 10(5): 409 - 419. [Abstract] [Full Text] [PDF]

				J. M. Tokish, M. S. Kocher, and R. J. Hawkins Ergogenic Aids: A Review of Basic Science, Performance, Side Effects, and Status in Sports Am. J. Sports Med., September 1, 2004; 32(6): 1543 - 1553. [Abstract] [Full Text] [PDF]

				P. Szulc, F. Duboeuf, F. Marchand, and P. D Delmas Hormonal and lifestyle determinants of appendicular skeletal muscle mass in men: the MINOS study Am. J. Clinical Nutrition, August 1, 2004; 80(2): 496 - 503. [Abstract] [Full Text] [PDF]

				S. Kelleher, A. J. Conway, and D. J. Handelsman Blood Testosterone Threshold for Androgen Deficiency Symptoms J. Clin. Endocrinol. Metab., August 1, 2004; 89(8): 3813 - 3817. [Abstract] [Full Text] [PDF]

				C. Meier, P. Y. Liu, L. P. Ly, J. de Winter-Modzelewski, M. Jimenez, D. J. Handelsman, and M. J. Seibel Recombinant Human Chorionic Gonadotropin But Not Dihydrotestosterone Alone Stimulates Osteoblastic Collagen Synthesis in Older Men with Partial Age-Related Androgen Deficiency J. Clin. Endocrinol. Metab., June 1, 2004; 89(6): 3033 - 3041. [Abstract] [Full Text] [PDF]

				C. Wang, G. Cunningham, A. Dobs, A. Iranmanesh, A. M. Matsumoto, P. J. Snyder, T. Weber, N. Berman, L. Hull, and R. S. Swerdloff Long-Term Testosterone Gel (AndroGel) Treatment Maintains Beneficial Effects on Sexual Function and Mood, Lean and Fat Mass, and Bone Mineral Density in Hypogonadal Men J. Clin. Endocrinol. Metab., May 1, 2004; 89(5): 2085 - 2098. [Abstract] [Full Text] [PDF]

				S. Asthana, S. Bhasin, R. N. Butler, H. Fillit, J. Finkelstein, S. M. Harman, L. Holstein, S. G. Korenman, A. M. Matsumoto, J. E. Morley, et al. Masculine Vitality: Pros and Cons of Testosterone in Treating the Andropause J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2004; 59(5): M461 - M465. [Full Text] [PDF]

				B. Z. Leder, J. L. Rohrer, S. D. Rubin, J. Gallo, and C. Longcope Effects of Aromatase Inhibition in Elderly Men with Low or Borderline-Low Serum Testosterone Levels J. Clin. Endocrinol. Metab., March 1, 2004; 89(3): 1174 - 1180. [Abstract] [Full Text] [PDF]

				E. T. Schroeder, L. Zheng, K. E. Yarasheski, D. Qian, Y. Stewart, C. Flores, C. Martinez, M. Terk, and F. R. Sattler Treatment with oxandrolone and the durability of effects in older men J Appl Physiol, March 1, 2004; 96(3): 1055 - 1062. [Abstract] [Full Text] [PDF]

				N. A. Evans Current Concepts in Anabolic-Androgenic Steroids Am. J. Sports Med., March 1, 2004; 32(2): 534 - 542. [Abstract] [Full Text] [PDF]

				L. J. Woodhouse, N. Gupta, M. Bhasin, A. B. Singh, R. Ross, J. Phillips, and S. Bhasin Dose-Dependent Effects of Testosterone on Regional Adipose Tissue Distribution in Healthy Young Men J. Clin. Endocrinol. Metab., February 1, 2004; 89(2): 718 - 726. [Abstract] [Full Text] [PDF]

				S. Bhasin, W. E. Taylor, R. Singh, J. Artaza, I. Sinha-Hikim, R. Jasuja, H. Choi, and N. F. Gonzalez-Cadavid The Mechanisms of Androgen Effects on Body Composition: Mesenchymal Pluripotent Cell as the Target of Androgen Action J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2003; 58(12): M1103 - 1110. [Abstract] [Full Text] [PDF]

				S. Bhasin Testosterone Supplementation for Aging-Associated Sarcopenia J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2003; 58(11): M1002 - 1008. [Abstract] [Full Text] [PDF]

				R. Singh, J. N. Artaza, W. E. Taylor, N. F. Gonzalez-Cadavid, and S. Bhasin Androgens Stimulate Myogenic Differentiation and Inhibit Adipogenesis in C3H 10T1/2 Pluripotent Cells through an Androgen Receptor-Mediated Pathway Endocrinology, November 1, 2003; 144(11): 5081 - 5088. [Abstract] [Full Text] [PDF]

				C. A. Thompson, T. D. Shanafelt, and C. L. Loprinzi Andropause: Symptom Management for Prostate Cancer Patients Treated With Hormonal Ablation Oncologist, October 1, 2003; 8(5): 474 - 487. [Abstract] [Full Text] [PDF]

				P. Y. Liu, B. Yee, S. M. Wishart, M. Jimenez, D. G. Jung, R. R. Grunstein, and D. J. Handelsman The Short-Term Effects of High-Dose Testosterone on Sleep, Breathing, and Function in Older Men J. Clin. Endocrinol. Metab., August 1, 2003; 88(8): 3605 - 3613. [Abstract] [Full Text] [PDF]

				J. Svartberg, R. Jorde, J. Sundsfjord, K. H. Bonaa, and E. Barrett-Connor Seasonal Variation of Testosterone and Waist to Hip Ratio in Men: The Tromso Study J. Clin. Endocrinol. Metab., July 1, 2003; 88(7): 3099 - 3104. [Abstract] [Full Text] [PDF]

				B. A. L. Crawford, P. Y. Liu, M. T. Kean, J. F. Bleasel, and D. J. Handelsman Randomized Placebo-Controlled Trial of Androgen Effects on Muscle and Bone in Men Requiring Long-Term Systemic Glucocorticoid Treatment J. Clin. Endocrinol. Metab., July 1, 2003; 88(7): 3167 - 3176. [Abstract] [Full Text] [PDF]

				C.J. Malkin, P.J. Pugh, T.H. Jones, and K.S. Channer Testosterone for secondary prevention in men with ischaemic heart disease? QJM, July 1, 2003; 96(7): 521 - 529. [Full Text] [PDF]

				J. E. Morley The Need for a Men's Health Initiative J. Gerontol. A Biol. Sci. Med. Sci., July 1, 2003; 58(7): M614 - 617. [Full Text] [PDF]

				G. A. Wittert, I. M. Chapman, M. T. Haren, S. Mackintosh, P. Coates, and J. E. Morley Oral Testosterone Supplementation Increases Muscle and Decreases Fat Mass in Healthy Elderly Males With Low-Normal Gonadal Status J. Gerontol. A Biol. Sci. Med. Sci., July 1, 2003; 58(7): M618 - 625. [Abstract] [Full Text] [PDF]

				I. Sinha-Hikim, S. M. Roth, M. I. Lee, and S. Bhasin Testosterone-induced muscle hypertrophy is associated with an increase in satellite cell number in healthy, young men Am J Physiol Endocrinol Metab, July 1, 2003; 285(1): E197 - E205. [Abstract] [Full Text] [PDF]

				C. Steidle, S. Schwartz, K. Jacoby, T. Sebree, T. Smith, and R. Bachand AA2500 Testosterone Gel Normalizes Androgen Levels in Aging Males with Improvements in Body Composition and Sexual Function J. Clin. Endocrinol. Metab., June 1, 2003; 88(6): 2673 - 2681. [Abstract] [Full Text] [PDF]

				S. Bhasin, A. B. Singh, R. P. Mac, B. Carter, M. I. Lee, and G. R. Cunningham Managing the Risks of Prostate Disease During Testosterone Replacement Therapy in Older Men: Recommendations for a Standardized Monitoring Plan J Androl, May 1, 2003; 24(3): 299 - 311. [Full Text] [PDF]

				L. J. Woodhouse, S. Reisz-Porszasz, M. Javanbakht, T. W. Storer, M. Lee, H. Zerounian, and S. Bhasin Development of models to predict anabolic response to testosterone administration in healthy young men Am J Physiol Endocrinol Metab, May 1, 2003; 284(5): E1009 - E1017. [Abstract] [Full Text] [PDF]

				T. W. Storer, L. Magliano, L. Woodhouse, M. L. Lee, C. Dzekov, J. Dzekov, R. Casaburi, and S. Bhasin Testosterone Dose-Dependently Increases Maximal Voluntary Strength and Leg Power, but Does Not Affect Fatigability or Specific Tension J. Clin. Endocrinol. Metab., April 1, 2003; 88(4): 1478 - 1485. [Abstract] [Full Text] [PDF]

				K. L. Herbst, B. D. Anawalt, J. K. Amory, A. M. Matsumoto, and W. J. Bremner The Male Contraceptive Regimen of Testosterone and Levonorgestrel Significantly Increases Lean Mass in Healthy Young Men in 4 Weeks, but Attenuates a Decrease in Fat Mass Induced by Testosterone Alone J. Clin. Endocrinol. Metab., March 1, 2003; 88(3): 1167 - 1173. [Abstract] [Full Text] [PDF]

				A. A. Ferrando, M. Sheffield-Moore, D. Paddon-Jones, R. R. Wolfe, and R. J. Urban Differential Anabolic Effects of Testosterone and Amino Acid Feeding in Older Men J. Clin. Endocrinol. Metab., January 1, 2003; 88(1): 358 - 362. [Abstract] [Full Text] [PDF]

				E. T. Schroeder, A. Singh, S. Bhasin, T. W. Storer, C. Azen, T. Davidson, C. Martinez, I. Sinha-Hikim, S. V. Jaque, M. Terk, et al. Effects of an oral androgen on muscle and metabolism in older, community-dwelling men Am J Physiol Endocrinol Metab, January 1, 2003; 284(1): E120 - E128. [Abstract] [Full Text] [PDF]

				K. T. Brill, A. L. Weltman, A. Gentili, J. T. Patrie, D. A. Fryburg, J. B. Hanks, R. J. Urban, and J. D. Veldhuis Single and Combined Effects of Growth Hormone and Testosterone Administration on Measures of Body Composition, Physical Performance, Mood, Sexual Function, Bone Turnover, and Muscle Gene Expression in Healthy Older Men J. Clin. Endocrinol. Metab., December 1, 2002; 87(12): 5649 - 5657. [Abstract] [Full Text] [PDF]

				P. T. Ellison, R. G. Bribiescas, G. R. Bentley, B. C. Campbell, S. F. Lipson, C. Panter-Brick, and K. Hill Population variation in age-related decline in male salivary testosterone Hum. Reprod., December 1, 2002; 17(12): 3251 - 3253. [Abstract] [Full Text] [PDF]

				F. R. Sattler, E. T. Schroeder, M. P. Dube, S. V. Jaque, C. Martinez, P. J. Blanche, S. Azen, and R. M. Krauss Metabolic effects of nandrolone decanoate and resistance training in men with HIV Am J Physiol Endocrinol Metab, December 1, 2002; 283(6): E1214 - E1222. [Abstract] [Full Text] [PDF]

				M. R. Blackman, J. D. Sorkin, T. Munzer, M. F. Bellantoni, J. Busby-Whitehead, T. E. Stevens, J. Jayme, K. G. O'Connor, C. Christmas, J. D. Tobin, et al. Growth Hormone and Sex Steroid Administration in Healthy Aged Women and Men: A Randomized Controlled Trial JAMA, November 13, 2002; 288(18): 2282 - 2292. [Abstract] [Full Text] [PDF]

				A. Fisher and J. E. Morley Editorial: Antiaging Medicine: The Good, the Bad, and the Ugly J. Gerontol. A Biol. Sci. Med. Sci., October 1, 2002; 57(10): M636 - 639. [Full Text] [PDF]

				T. A. Roy, M. R. Blackman, S. M. Harman, J. D. Tobin, M. Schrager, and E. J. Metter Interrelationships of serum testosterone and free testosterone index with FFM and strength in aging men Am J Physiol Endocrinol Metab, August 1, 2002; 283(2): E284 - E294. [Abstract] [Full Text] [PDF]

				P. Y. Liu, S. M. Wishart, and D. J. Handelsman A Double-Blind, Placebo-Controlled, Randomized Clinical Trial of Recombinant Human Chorionic Gonadotropin on Muscle Strength and Physical Function and Activity in Older Men with Partial Age-Related Androgen Deficiency J. Clin. Endocrinol. Metab., July 1, 2002; 87(7): 3125 - 3135. [Abstract] [Full Text] [PDF]

				N. Tamaya-Mori, K. Uemura, and A. Iguchi Gender Differences in the Dietary Lard-Induced Increase in Blood Pressure in Rats Hypertension, May 1, 2002; 39(5): 1015 - 1020. [Abstract] [Full Text] [PDF]

				C. Wang and R. S. Swerdloff Should the Nonaromatizable Androgen Dihydrotestosterone Be Considered as an Alternative to Testosterone in the Treatment of the Andropause? J. Clin. Endocrinol. Metab., April 1, 2002; 87(4): 1462 - 1466. [Full Text] [PDF]

				M. R. Smith, J. S. Finkelstein, F. J. McGovern, A. L. Zietman, M. A. Fallon, D. A. Schoenfeld, and P. W. Kantoff Changes in Body Composition during Androgen Deprivation Therapy for Prostate Cancer J. Clin. Endocrinol. Metab., February 1, 2002; 87(2): 599 - 603. [Abstract] [Full Text] [PDF]

				A. M. Matsumoto Andropause: Clinical Implications of the Decline in Serum Testosterone Levels With Aging in Men J. Gerontol. A Biol. Sci. Med. Sci., February 1, 2002; 57(2): M76 - 99. [Full Text]

				A. B. Singh, S. Hsia, P. Alaupovic, I. Sinha-Hikim, L. Woodhouse, T. A. Buchanan, R. Shen, R. Bross, N. Berman, and S. Bhasin The Effects of Varying Doses of T on Insulin Sensitivity, Plasma Lipids, Apolipoproteins, and C-Reactive Protein in Healthy Young Men J. Clin. Endocrinol. Metab., January 1, 2002; 87(1): 136 - 143. [Abstract] [Full Text] [PDF]

				S. Bhasin, L. Woodhouse, R. Casaburi, A. B. Singh, D. Bhasin, N. Berman, X. Chen, K. E. Yarasheski, L. Magliano, C. Dzekov, et al. Testosterone dose-response relationships in healthy young men Am J Physiol Endocrinol Metab, December 1, 2001; 281(6): E1172 - E1181. [Abstract] [Full Text] [PDF]

				National Institute on Ageing Advisory Panel SPECIAL REPORT: Report of National Institute on Aging Advisory Panel on Testosterone Replacement in Men J. Clin. Endocrinol. Metab., October 1, 2001; 86(10): 4611 - 4614. [Full Text] [PDF]

				L. P. Ly, M. Jimenez, T. N. Zhuang, D. S. Celermajer, A. J. Conway, and D. J. Handelsman A Double-Blind, Placebo-Controlled, Randomized Clinical Trial of Transdermal Dihydrotestosterone Gel on Muscular Strength, Mobility, and Quality of Life in Older Men with Partial Androgen Deficiency J. Clin. Endocrinol. Metab., September 1, 2001; 86(9): 4078 - 4088. [Abstract] [Full Text] [PDF]

				T. Munzer, S. M. Harman, P. Hees, E. Shapiro, C. Christmas, M. F. Bellantoni, T. E. Stevens, K. G. O'Connor, K. M. Pabst, C. St. Clair, et al. Effects of GH and/or Sex Steroid Administration on Abdominal Subcutaneous and Visceral Fat in Healthy Aged Women and Men J. Clin. Endocrinol. Metab., August 1, 2001; 86(8): 3604 - 3610. [Abstract] [Full Text] [PDF]

				P. J. Snyder Effects of Age on Testicular Function and Consequences of Testosterone Treatment J. Clin. Endocrinol. Metab., June 1, 2001; 86(6): 2369 - 2372. [Full Text] [PDF]

				A. Vermeulen Androgen Replacement Therapy in the Aging Male--A Critical Evaluation J. Clin. Endocrinol. Metab., June 1, 2001; 86(6): 2380 - 2390. [Full Text] [PDF]

				J. E. Morley Editorial: Andropause: Is It Time for the Geriatrician to Treat It? J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2001; 56(5): 263M - 265. [Full Text]

				S. M. Harman, E. J. Metter, J. D. Tobin, J. Pearson, and M. R. Blackman Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men J. Clin. Endocrinol. Metab., February 1, 2001; 86(2): 724 - 731. [Abstract] [Full Text]

				R. S. Swerdloff, C. Wang, G. Cunningham, A. Dobs, A. Iranmanesh, A. M. Matsumoto, P. J. Snyder, T. Weber, J. Longstreth, and N. Berman Long-Term Pharmacokinetics of Transdermal Testosterone Gel in Hypogonadal Men J. Clin. Endocrinol. Metab., December 1, 2000; 85(12): 4500 - 4510. [Abstract] [Full Text]

				F. J. Hayes Testosterone--Fountain of Youth or Drug of Abuse? J. Clin. Endocrinol. Metab., September 1, 2000; 85(9): 3020 - 3023. [Full Text]

This Article Abstract Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Snyder, P. J. Articles by Strom, B. L. Search for Related Content PubMed PubMed Citation Articles by Snyder, P. J. Articles by Strom, B. L.