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The Journal of Clinical Endocrinology & Metabolism Vol. 84, No. 2 822
Copyright © 1999 by The Endocrine Society

Letters to the Editor

Comment on Dried Blood Spot Assay of IGF-I and IGFBP-3

M. L. Mitchell and Hermos;

New England Newborn Screening Program Jamaica Plain, Massachusetts 02130 A. C. Moses Beth Israel Deaconess Medical Center Boston, Massachusetts 02215

We read with interest the article (1) describing a filter paper blood spot assay for IGF-1 and IGFBP-3, in which the authors proposed its application in pediatric and large scale screening programs. With regard to IGF-1, such application has been carried out in a variety of studies on newborns. Using an RIA procedure devised for the assay of IGF-1 (2), we measured IGF-1 concentrations in the routine filter paper blood specimens of infants with congenital hypothyroidism and normal controls (3). Additional studies were done, also using routine newborn filter paper blood specimens, in which concentrations of IGF-1 were determined in normal and low birth weight infants (4). Because of limited data on healthy children we established reference ranges for IGF-1 using filter paper blood specimens obtained from boys and girls ages 1–18 yr (5).

In addition to the advantages of filter paper mentioned in these studies, monitoring of patients can be done outside of a clinical setting. With minimal instruction, families can be taught to collect blood on filter paper by heel or finger prick and forward such specimens to the laboratory for specific analysis. This approach has been utilized in managing children with congenital hypothyroidism by assays of T4 and TSH (6) and children with congenital adrenal hyperplasia by measuring concentrations of 17-hydroxyprogesterone (7).

Footnotes

Received July 29, 1998. Address correspondence to: Marvin L. Mitchell, New England Newborn Screening Program, University of Massachusetts Medical Center, 305 South Street, Jamaica Plain, Massachusetts 02130.

References

  1. Diamandi A, Khosravi JM, Mistry J, Martinez V, Guevara-Aguirre J. 1998 Filter paper blood spot assay of human insulin-like growth factor I(IGF-I) and IGF-binding protein-3 and preliminary application in the evaluation of growth hormone status. J Clin Endocrinol Metab. 83:2296–2301.[Abstract/Free Full Text]
  2. Mitchell ML, Hermos RJ, Moses AC. 1987 Radioimmunassay of somatomedin-C in filter paper discs containing dried blood. Clin Chem. 33:536–538.[Abstract/Free Full Text]
  3. Mitchell ML, Hermos RJ, Moses AC. 1987 Somatomedin-C/insulin-like growth factor-1 in infants with congenital hypothyroidism during the first week of life. Clin Endocrinol. 27:625–628.[Medline]
  4. Mitchell ML, Hermos RJ, Feingold M, Moses AC. 1989 The relationship of insulin-like growth factor-1 to total thyroxine in normal and low birth weight infants. Pediatr Res. 25:336–338.[Medline]
  5. Mitchell ML, Hermos RJ, Schoepfer A, Orson JM. 1990 Reference ranges for insulin-like growth factor-1 in healthy children and adolescents, determined with filter-paper blood specimens. Clin Chem. 36:2138.[Free Full Text]
  6. New England Congenital Hypothyroidism Collaborative. 1994 Correlation of cognitive test scores and adequacy of treatment in adolescents with congenital hypothyroidism. J Pediatr. 124:383–387.[CrossRef][Medline]
  7. Sieratzki JS, Gompels C, Poyser K, Beaman J, Savage DCL. 1995 Filter paper cortisol profiles in secondary adrenocortical insufficiency. Arch Dis in Child. 73:351–353.




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