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Human Fetal Pituitary Expresses Functional GHRP Receptors—Authors’ Response^e

Cedars-Sinai Medical Center Los Angeles, California 90048-1865

We appreciate the comments of Drs. Adams and Buchfelder in the letter above. As we wrote, the aim of our study was to study GHRP receptor expression in normal pituitary cells. Despite previous reports of GHRP action on tumorous adenoma cells (cited by Adams and Buchfelder), those studies all preceded the cloning of the GHRP receptor in 1996 (1), and therefore it would have been impossible for us to cite them, even as putative examples of tumor GHRP receptor expression. We appropriately cited earlier in vivo observations indicating GHRP responsiveness in normal man (2, 3, 4, 5, 6). These clinical observations in normal adults served as background for our studies in normal human pituitary cells. We did not cite previous in vitro tumor cell culture heterogenous responses, as our work was a physiologic study of normal human somatotroph GHRP receptor expression and response. We elected to restrict our citations to primary events.

Footnotes

Address correspondence to: Shlomo Melmed, Division of Endocrinology and Metabolism, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Suite B-131, Los Angeles, California 90048.

Received March 26, 1998.

References

1. Howard AD, Feighner SD, Cully DF, et al. 1996 A receptor in pituitary and hypothalamus that functions in growth hormone release. Science. 273:974–977.[Abstract]
2. Bowers CY, Reynolds GA, Durham D, Barrera CM, Pezzoli SS, Thorner MO. 1990 Growth hormone (GH) releasing peptide stimulates GH release in normal men and acts synergistically with GH-releasing hormone. J Clin Endocrinol Metab. 70:975–982.[Abstract]
3. Hartman AD, Feighner SD, Cully DF, et al. 1996 A receptor in pituitary and functions in growth hormone (GH)-releasing peptide stimulates GH secretion in normal men. J Clin Endocrinol Metab. 74:1378–1384.[Abstract]
4. Popovic V, Damjanovic S, Micic D, Djurovic M, Dieguez C, Casanueva FF. 1995 Blocked growth hormone-releasing peptide (GHRP-6)-induced GH secretion and absence of the synergic action of GHRP-6 plus GH-releasing hormone in patients with hypopituitary disconnection: evidence that GHRP-6 main action is exerted at the hypothalamic level. J Clin Endocrinol Metab. 80:942–947.[Abstract]
5. Bowers CY, Alster DK, Frentz JM. 1992 The growth hormone-releasing activity of a synthetic hexapeptide in normal men and short-statured children after oral administration. J Clin Endocrinol Metab. 74:292–298.[Abstract]
6. Frieboes RM, Murck H, Maier P, Schier T, Holsboer F, Steiger A. 1995 Growth hormone-releasing peptide-6 stimulates sleep growth hormone, ACTH and cortisol release in normal man. Neuroendocrinology. 61:584–589.[Medline]

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