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The Journal of Clinical Endocrinology & Metabolism Vol. 83, No. 4 1384-1387
Copyright © 1998 by The Endocrine Society

Rapid Communications

Retinoid Receptors Expression in Human Term Placenta: Involvement of RXR{alpha} in Retinoid Induced-hCG Secretion

J. Guibourdenche, E. Alsat, F. Soncin, C. Rochette-Egly and D. Evain-Brion

Unité INSERM 427 (J.G., E.A., F.S., D.E.-B.), Faculté des Sciences Pharmaceutiques et Biologiques, Université René Descartes Paris V, 75006 Paris; CNRS (C.R.-E.)/INSERM/Université Louis Pasteur, 67404 Illkirch, France

Address correspondence to: D. Evain-Brion, Unite INSERM 427, Faculte des Sciences Pharmaceutiques et Biologiques, Unìversité René Descartes Paris V, 4 avenue de l’Observatoire, Paris 75006, France.

Abstract

To investigate the role of retinoids on human placental development and functions, we characterized the spatial distribution of retinoid receptors in human term chorionic villi. In situ hybridization with 35S labeled sense and antisense probes for the RARs, {alpha}, ß, {gamma} and RXRs, {alpha}, ß, {gamma}, specifically detected only RAR{alpha} and RXR{alpha}. Both RAR{alpha} and RXR{alpha} mRNA were preferentially expressed in the trophoblast cell layer. This syncytiotrophoblast expression was confirmed by immunohistochemical analyses using anti-RAR{alpha} and RXR{alpha} antibodies. Using trophoblast cells in culture, we then studied the effect on hCG secretion of 0.1 µM RA physiological forms and of selective RAR{alpha} and RXR{alpha} synthetic agonists. Only RXR{alpha} specific ligands such as physiological 9-cis RA and synthetic Ro 25-7386 stimulated hCG secretion (doubled). These results suggest an important role for RXR{alpha} in human placental development and function.

Received December 4, 1997.




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