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Nocturnal Rise of Leptin in Normal Prepubertal and Pubertal Children and in Patients with Perinatal Stalk-Transection Syndrome

Departments of Pediatrics (M.P., J.B.), Medicine (F.F.C.), and Physiology (C.D.), Faculty of Medicine, Complejo Hospitalario Universitario, Santiago de Compostela; Department of Endocrinology (E.H.J., M.J.G., T.M.), Hospital Clínico, Sevilla; Bioengineering and Chronobiology Laboratories (R.C.H.), E.T.S.I. Telecommunación, University of Vigo, Vigo, Spain; Department of Medicine (R.V.C.), Indiana University, Indianapolis, Indiana

Address correspondence to: Carlos Dieguez, Department of Medicine, Complejo Hospitalario Unìversity de Santiago, Santiago de Compostela University, P.O. Box 563, Santiago de Compostela, Spain E-15780.

Abstract

We studied 24-h profiles of circulating leptin levels using a sensitive and specific radioimmunoassay in healthy pre- (Tanner 1) and pubertal boys and girls (Tanner 3-4) as well as in a group of patients with perinatal stalk-transection syndrome. Similar nyctohemeral rhythm in serum leptin levels were found in prepubertal (MESOR: 2.34 ± 0.2 ng/ml; amplitude 0.32 ± 0.1 ng/ml) and pubertal boys (MESOR 2.2 ± 0.2 ng/ml; amplitude 0.38 ± 0.07 ng/ml). Likewise, no differences were found between prepubertal (MESOR 6.6 ± 1.07 ng/ml; amplitude 1.67 ± 0.4 ng/ml) and pubertal girls (MESOR 4.05 ± 0.5 ng/ml; amplitude 0.95 ± 0.2 mg/ml). In contrast, higher MESOR (P < 0.002) and amplitude values (P < 0.005) were found in prepubertal and pubertal girls than in prepubertal and pubertal boys. Finally a significant nyctohemeral rhythm in serum leptin levels was found in patients with perinatal stalk-transection syndrome (MESOR: 9.3 ± 2.3 ng/ml; amplitude 1.46 ± 0.4 ng/ml). This data shows the existence of sexual dimorphism in the nyctohemeral rhythm in serum leptin levels that are not influenced by the pubertal stage or by pulsatile anterior pituitary hormone secretion.

Received April 30, 1997.

Revised May 29, 1997.

Accepted June 9, 1997.

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