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Clinical Studies |
Lilly Research Centre, Erl Wood Manor (A.F.A., A.M.C.M., M.A.B., P.C.B.), Windlesham, Surrey GU20 6PH, United Kingdom; Erasmus University (S.W.J.L., N.K.V.), 3015 GD Rotterdam, The Netherlands; Department of Internal Medicine & Endocrinology, Hvidovre Hospital (J.H.), DK-2650 Hvidovre, Denmark; Research Centre for Endocrinology & Metabolism, Sahlgrenska University Hospital (B.B.), Goteborg, Sweden; and Medizinische Klinik Innenstadt (C.J.S.), Munchen, Germany
Address all correspondence and requests for reprints to: Steven W.J. Lamberts, University Hospital Dijkzigt, 40 Dr Molewaterplein, 3015 GD Rotterdam, The Netherlands.
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Abstract |
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At baseline the height, body weight, body mass index, lean body mass, and waist/hip ratio of AO patients were significantly (P < 0.001) greater than in CO patients. Serum insulin-like growth factor-I (IGF-I) levels were below normal but were lower in CO than AO patients (P < 0.001), and the correlation with IGF binding protein-3 was stronger in CO than in AO patients. Osteocalcin concentration in CO patients was above the normal range and significantly greater than in AO patients. Both groups had significant psychosocial distress, but the deviation from normality was greater in AO patients. Throughout GH therapy there was a significant increase in lean body mass and significant decrease in percent body fat and sum of skinfolds in each group. Waist/hip ratio was decreased by long-term therapy in AO but not CO patients. Total and low density lipoprotein cholesterol levels were decreased from baseline at 6 months in AO but not CO patients and high density lipoprotein cholesterol was increased in both groups throughout therapy. IGF-I and IGF binding protein-3 were increased into the normal range by GH therapy in both groups. Mean osteocalcin level in AO patients was increased at 6 months with no further change with GH therapy, whereas in CO patients there was a steep increase up to 12 months but then a sharp decrease. Nottingham Health Profile scores showed significant improvements in physical mobility and energy at 18 months of therapy in AO patients but no consistent effects in CO patients. GH-induced side effects were mainly reported by AO patients; very few CO patients reported treatment-emergent adverse events.
These results demonstrate significant differences in clinical and biochemical presentation and responses to therapy of the adult GH deficiency syndrome. This is consistent with the existence of two entities, developmental (CO) and metabolic (AO), and the different functions of GH at different periods of life.
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Introduction |
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TopAbstractIntroductionPatients and MethodsResultsDiscussionReferences |
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However, adult GH deficiency is not a single clinical entity because the onset may occur during either childhood (CO) or adult life (AO). GH deficiency occurring in children is mainly idiopathic and is recognized as growth failure. Appropriate therapy with GH, standardized over the past decade, is discontinued when final height is reached. Somatic development is unlikely to be complete at this stage, and when GH therapy is withdrawn the untreated deficiency results in increased prevalence of obesity (18, 19). However, these CO patients adapt to the GH-deficient situation during development, whereas patients who have not been deficient during childhood undergo normal somatic development. Acquiring GH deficiency as an adult because of pituitary damage or removal leads to reversal of previously normal GH effects.
Although previous studies with only small numbers of patients may have focused on one group more than the other, differential effects of therapy for AO and CO adult GH-deficient patients have not been reported. The present report involved a large number of adult patients enrolled in a placebo-controlled clinical trial of efficacy and safety of long-term GH therapy. This is the first report that differentiates therapeutic effects in patients on the basis of the time of onset of the deficiency.
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Patients and Methods |
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TopAbstractIntroductionPatients and MethodsResultsDiscussionReferences |
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A total of 173 patients were enrolled to participate in a multinational, randomly assigned, blinded, placebo-controlled study, sponsored and monitored by Lilly Research Centre, Windlesham, Surrey, U.K., and with ethical approval according to local and national requirements. Patients were included into two protocols, identical except that patients had GH deficiency arising either during adult life (AO) and that was present for at least 1 yr or during childhood (CO), with GH therapy to final height but no GH treatment in the previous 2 yr. Diagnosis of GH deficiency, from a peak serum GH level <5 µg/L in a standard stimulation test, was required for inclusion. The most frequently performed tests were arginine (AO: n = 31; CO: n = 24), insulin tolerance (AO: n = 42; CO: n = 3), and clonidine (AO: n = 1; CO: n = 31), but other test substances used were GHRH, L-dopa, and glucagon. Replacement therapy with cortisol, thyroxine, sex steroids, and vasopressin had to be stable for at least 6 months before the start of the study, and patients with hypertension were excluded.
Patients were randomly assigned to receive either human biosynthetic GH (Humatrope, Lilly Research Centre) or placebo, administered sc at 6.25 µg/kg per day for the first 4 weeks and then increased to a maximum of 12.5 µg/kg per day (double-blind) for a period of 6 months. Thereafter, all patients were treated with open-label GH for an additional 12 months. Thus patients were on GH for a total of either 18 months (GH/GH) or 12 months (placebo/GH). For the AO group, 52 patients were randomly assigned to GH/GH, and 46 patients were randomly assigned to placebo/GH; for the CO group, 32 patients were randomly assigned to GH/GH and 35 were randomly assigned to placebo/GH. One patient in AO and 7 in the CO group were enrolled but not randomly assigned to a treatment and were included in baseline but not therapy analyses.
Anthropometric measurements and body composition
Weight and height distributions were compared with reference standards for a normal adult population (20). Weight ranges were also evaluated using body mass index (BMI) calculated from weight/height2. Waist and hip circumferences were measured and waist/hip ratio calculated. Skinfold thicknesses were measured at triceps, biceps, subscapular, and suprailiac sites and added together for each patient to give a sum of skinfolds value.
Bioelectrical-impedance was measured, and total body water and LBM calculated using the formula provided by the manufacturer of the body composition analyzer (Holtain, Dyfed, U.K.). Body fat mass was calculated from the difference between total body weight and LBM, and percent body fat calculated as a proportion of body weight.
Serum biochemistry
Total cholesterol, high density lipoprotein (HDL) cholesterol, and low density lipoprotein (LDL) cholesterol concentrations were measured by standard techniques. Insulin-like growth factor-I (IGF-I) was measured by an IGF binding protein (IGFBP)-blocked RIA (21) using a kit supplied by BioMerieux (Nurtingen, Germany). IGFBP-3 was measured by a two-site immunoassay (22). Osteocalcin concentration was measured by standard RIA.
Quality of life assessment
Quality of life was assessed from the Nottingham Health Profile (NHP) questionnaire (Galen Research, Manchester, U.K.), and the data analyzed by Galen Research for each of the subsections. NHP scores are inversely related to the patient’s quality of life, i.e. a higher score indicates a worse quality of life. Scores from age and sex-matched control subjects are included for comparison of pretherapy data.
Statistical analyses
For baseline comparison of AO and CO patients, the analysis was performed using a model incorporating effects for onset, gender, and interactions of onset-by-gender, except where analysis of covariance indicated a significant effect of age (BMI, waist/hip ratio, IGFs, osteocalcin, total cholesterol) when the model also incorporated effects for age (SAS PROC GLM; 23). Analysis was performed on both original and rank transformed data, although only results based on rank transformed data are presented. Spearman correlation coefficients were used to examine the linear relationship between two variables.
Efficacy results were analyzed for between-treatment comparisons of change from baseline to endpoint (last visit in the double-blind period) using ANOVA incorporating effects for treatment, investigator, and treatment-by-investigator interactions using rank transformed data. Within-treatment analyses were performed using a sign test.
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Results |
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TopAbstractIntroductionPatients and MethodsResultsDiscussionReferences |
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Demographic, anthropometric, and body composition. The
spectrum of causes of GH deficiency (Table 1
) was
entirely different between the two patient groups. Idiopathic GH
deficiency was recorded for 89.5% of CO patients. Concomitant
medications in this group were thyroxine (54%), cortisol (28%), sex
steroids (60%), and vasopressin (9%). In AO subjects, the predominant
cause of GH deficiency was surgical intervention for (peri-)pituitary
tumors (82%), mainly adenomas. Concomitant medications were thyroxine
(83%), cortisol (79%), sex steroids (86%), and vasopressin (23%).
The highest reported peak GH values in the stimulation tests were 4.3
and 4.6 µg/L in AO and CO patients, respectively.
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. CO patients were significantly (P <
0.001) younger than AO patients and, although full-grown, were
significantly (P < 0.001) shorter. Comparison with an
adult height reference standard (23) indicated that for the CO group
approximately 50% of both males and females had height values below
the 2 SD normal range, whereas the distribution for AO
subjects was almost identical to the reference standard. There was a
significant correlation with age for BMI and waist/hip ratio. However,
after correction for age, mean values were significantly
(P < 0.001) higher in AO than in CO patients.
Correlations of waist/hip ratio with weight and BMI were very strong in
AO males (weight: r = 0.45, P < 0.001; BMI:
r = 0.60, P < 0.001) but less strong in CO males
(weight: r = 0.22, P = 0.106; BMI: r = 0.40,
P = 0.002).
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) was significantly
(P < 0.001) less in CO than AO patients, and in each
group males had significantly (P < 0.001) higher
values than females. Comparison with reference values (1, 3, 24, 25)
from an age- and sex-matched normal population assessed with the same
methodology showed that LBM was decreased (P < 0.01)
in CO but not in AO individuals. The mean body fat mass was less in CO
than AO (P < 0.001) patients, although the percentage
body fat was very similar between the two groups. In comparison with
reference standards (1, 3, 24, 25), both CO and AO patients had
significantly greater fat mass and percentage body fat. The sum of
skinfold measurements confirmed the bioimpedance data because there was
no statistically significant difference between the mean values for the
AO and CO groups.
Hormone and clinical chemistry measurements. Mean baseline
values for serum concentrations of IGF-I, IGFBP-3, and osteocalcin are
presented in Table 2. IGF-I levels were significantly
(P < 0.001) lower in CO patients than in AO patients,
although the mean concentration in each group was below the normal
adult reference range (21). In the AO but not in the CO group, the
values for males were significantly higher than those for female
patients. IGFBP-3 values in AO patients were within the normal range
but were significantly (P < 0.001) greater than in CO
patients, which were below the normal range. The correlation of IGFBP-3
with IGF-I values was not as strong in AO (r = 0.58) as in CO
(r = 0.93) patients. Osteocalcin concentration was within the
normal adult range in AO, whereas it was elevated in CO patients and
significantly (P < 0.001) greater than that of AO
patients.
Mean serum total cholesterol levels (Table 2) were elevated for both AO
and CO groups when compared with age- and sex-matched normal ranges
from the central laboratory. Mean HDL cholesterol levels were lower
than normal in AO but not in CO patients, although 72% of AO and 54%
of CO patients had abnormal HDL cholesterol values.
Quality of life assessment. Baseline NHP scores (Table 3) showed that both CO and AO patients had scores that
were higher (worse) than a normal population matched for age and sex.
However, CO patients generally had lower scores (a lower level of
distress) than AO patients. For the dimensions of physical mobility and
energy level the differences between AO and CO patients were
statistically significant (P < 0.01).
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Double-blind comparison at 6 months. The mean values at
baseline and changes from baseline at the 6-month endpoint for primary
efficacy variables are shown in Table 4. For both the AO
and CO groups there was a significant increase in LBM and decrease in
percent body fat in the GH-treated patients in comparison with baseline
values and with placebo-treated patients. Total cholesterol
concentration was significantly decreased from baseline only in AO
patients, but in neither group was the GH-induced change significant by
comparison with placebo treatment. HDL cholesterol concentration was
increased from baseline by GH in both AO and CO patients, but only in
AO patients was the increase significant in comparison with placebo
treatment. There was a significant change from baseline in LDL
cholesterol concentration in the AO but not in the CO group. GH therapy
increased IGF-I and IGFBP-3 concentrations within 6 months, and the
increases were maintained to the 18-month endpoint.
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) showed parallel significant
(P < 0.001) increases at 6 months with little change
thereafter. The sum of skinfolds was significantly decreased by GH
therapy at each time point (P < 0.001 at 6-, 12-, and
18-month endpoints) in both AO and CO patients. Waist/hip ratio was
significantly decreased at 12 and 18 months only in the AO group
(change from baseline to: 12 months, -0.012 ± 0.055,
P = 0.024; 18 months, -0.019 ± 0.048,
P = 0.005) and was not changed throughout treatment in
the CO patients.
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) in AO patients at 6 months, with no further
change throughout treatment. In CO patients there was a steep increase
up to 12 months of GH therapy but then a sharp decrease.
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) was significantly increased from baseline at each
time point for both groups. The ratio of HDL cholesterol to LDL
cholesterol (Fig. 3b) was also significantly increased throughout the
18 months of GH therapy.
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Safety parameters. There were no serious adverse events
related to therapy for either group. In the AO group, therapy was
discontinued in four patients (4.1%) because of adverse events; one
because of recurrence of craniopharyngioma, one because of hypertension
and arthralgia, one because of abnormal glucose tolerance, and the last
because of a viral illness. In the CO group, therapy was discontinued
in three patients (4.5%) because of adverse events; one becaues of
hepatitis, one from the same study center because of increased liver
enzyme levels, and the third because of joint disorder. Expected side
effects of GH therapy were reported throughout the study, and events
reported at a frequency of 
5% are shown in Table 5.
Treatment-emergent adverse events were mainly reported in AO patients,
with very few reported by CO patients.
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Discussion |
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TopAbstractIntroductionPatients and MethodsResultsDiscussionReferences |
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Baseline anthropometric and body composition measurements describe the clinical presentation of the adult GH deficiency syndrome and are indicative of its heterogeneity. In terms of height and body shape, CO patients differed significantly from AO patients. CO patients were somatically underdeveloped and retained typical features of hypopituitary dwarfism. This was despite the previous treatment of all of the CO patients with GH, which was pituitary derived in the majority of cases. These patients therefore may not have benefited from modern optimized therapy with recombinant GH (26), which has significantly improved final height outcome during the last decade. However, the emphasis for treatment of pediatric patients remains final height and other maturational aspects, and their impact on later adult life are still poorly understood.
In CO patients, both IGF-I and IGFBP-3 levels were significantly lower than in AO patients and were strongly correlated, similar to the relationship found in childhood (21). In AO patients, IGF-I and IGFBP-3 values did not correlate as strongly, and IGFBP-3 levels were within the normal range. Baseline data therefore indicated that in AO patients the regulation of IGFBP-3 is different, and that IGFBP-3 measurements cannot be used for diagnosis of AO GH deficiency, as established in CO patients. GH therapy increased IGF-I and IGFBP-3 concentrations into the normal range, but did not change the relationships.
Differences in serum osteocalcin levels at baseline and in response to GH therapy indicates that bone biology also differs between AO and CO patients. Withdrawal of GH therapy in hypopituitary dwarfs at epiphyseal closure may prevent full maturation of the bones in these patients. Some studies, although not prospective, have provided indirect evidence that in CO adult GH-deficient patients the bone mineral density is lower than in GH-deficient AO subjects (27, 28), and that their response to GH therapy may be better (28).
Assessing body composition by bioelectrical impedance has shortcomings (2) but is the most feasible method in a large multicenter trial and detects therapy effects with significant power. During the 6-month double-blind period, significant and comparable increases in LBM and decreases in body fat were observed in both AO and CO patients. The significant increases in LBM persisted to 18 months of therapy. However, the waist/hip ratio was decreased only in AO patients, indicating a preferential decrease in intraabdominal fat.
GH treatment also caused a significant long-term increase in HDL cholesterol concentration and HDL/LDL cholesterol ratio. Adult patients with CO deficiency have previously been reported to have normal HDL cholesterol levels (5), which were not altered by GH therapy (29), consistent with the smaller alteration in lipid values in the CO than the AO patients in the present study.
The heterogeneity between the AO and CO patients was confirmed by the changes in the quality of life and by treatment-related adverse events. AO patients showed a significant improvement in quality of life, whereas CO patients showed no long-term changes. AO patients would have previously experienced a normal adult quality of life and therefore conceivably have suffered more from the GH deficiency than the CO patients who had grown up with and adapted to it. The NHP results in the AO group demonstrate the specific therapy effect and are indicative of the high motivation of these patients. The differences in GH-induced side effects between AO and CO patients primarily may reflect the disposition of the patients to therapy (30). Reported events could reflect real differences in responsiveness, or that CO patients accept any problems whereas AO patients report everything.
In conclusion, this study indicates that there are two distinct entities to the adult GH deficiency syndrome. AO deficiency is a relatively clear clinical/biochemical entity in which the symptoms and their correction by therapy correlate well with the biological actions of GH. CO GH deficiency is more complex because it has both pediatric/developmental and adult/metabolic components, in agreement with the different functions of GH during these two stages of life. It is possible that the CO patients in the present study had not yet developed the full clinical picture of the adult GH deficiency syndrome. However, the treatment rationale in adult GH-deficient patients will differ to correct the symptoms of the syndrome in AO patients but to prevent development of the symptoms of GH deficiency in CO patients.
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Footnotes |
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2 The principal investigators in the Study Group were E. Cacciari,
Bologna, Italy; B. Charbonnel, Nantes, France; G. Chiumello, Milano,
Italy; P. Fossati, Lille, France; N. Lokkgaard, Hvidovre, Denmark; R.T.
Jung, Dundee, United Kingdom; P.C. Scriba, Munchen, Germany; O.E.
Trygstad, Oslo, Norway; S. Webb, Barcelona, Spain; and C. Wüster,
Heidelberg, Germany.
Received June 7, 1996.
Revised August 14, 1996.
Accepted September 4, 1996.
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A. R. Hoffman, C. J. Strasburger, A. Zagar, W. F. Blum, A. Kehely, and M. L. Hartman Efficacy and Tolerability of an Individualized Dosing Regimen for Adult Growth Hormone Replacement Therapy in Comparison with Fixed Body Weight-Based Dosing J. Clin. Endocrinol. Metab., July 1, 2004; 89(7): 3224 - 3233. [Abstract] [Full Text] [PDF]
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P. Maison, S. Griffin, M. Nicoue-Beglah, N. Haddad, B. Balkau, and P. Chanson Impact of Growth Hormone (GH) Treatment on Cardiovascular Risk Factors in GH-Deficient Adults: A Metaanalysis of Blinded, Randomized, Placebo-Controlled Trials J. Clin. Endocrinol. Metab., May 1, 2004; 89(5): 2192 - 2199. [Abstract] [Full Text] [PDF]
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M. Hayakawa, Y. Shimazaki, T. Tsushima, Y. Kato, K. Takano, K. Chihara, A. Shimatsu, and M. Irie Metabolic Effects of 20-Kilodalton Human Growth Hormone (20K-hGH) for Adults with Growth Hormone Deficiency: Results of an Exploratory Uncontrolled Multicenter Clinical Trial of 20K-hGH J. Clin. Endocrinol. Metab., April 1, 2004; 89(4): 1562 - 1571. [Abstract] [Full Text] [PDF]
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M. Rosilio, W. F. Blum, D. J. Edwards, E. P. Shavrikova, D. Valle, S. W. J. Lamberts, E. M. Erfurth, S. M. Webb, R. J. Ross, K. Chihara, et al. Long-Term Improvement of Quality of Life During Growth Hormone (GH) Replacement Therapy in Adults with GH Deficiency, as Measured by Questions on Life Satisfaction-Hypopituitarism (QLS-H) J. Clin. Endocrinol. Metab., April 1, 2004; 89(4): 1684 - 1693. [Abstract] [Full Text] [PDF]
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M. Tauber, B. Jouret, A. Cartault, N. Lounis, M. Gayrard, C. Marcouyeux, C. Pienkowski, I. Oliver, P. Moulin, P. Otal, et al. Adolescents with Partial Growth Hormone (GH) Deficiency Develop Alterations of Body Composition after GH Discontinuation and Require Follow-Up J. Clin. Endocrinol. Metab., November 1, 2003; 88(11): 5101 - 5106. [Abstract] [Full Text] [PDF]
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L. E. Underwood, K. M. Attie, and J. Baptista Growth Hormone (GH) Dose-Response in Young Adults with Childhood-Onset GH Deficiency: A Two-Year, Multicenter, Multiple-Dose, Placebo-Controlled Study J. Clin. Endocrinol. Metab., November 1, 2003; 88(11): 5273 - 5280. [Abstract] [Full Text] [PDF]
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W. F. Blum, E. P. Shavrikova, D. J. Edwards, M. Rosilio, M. L. Hartman, F. Marin, D. Valle, A. J. van der Lely, A. F. Attanasio, C. J. Strasburger, et al. Decreased Quality of Life in Adult Patients with Growth Hormone Deficiency Compared with General Populations Using the New, Validated, Self-Weighted Questionnaire, Questions on Life Satisfaction Hypopituitarism Module J. Clin. Endocrinol. Metab., September 1, 2003; 88(9): 4158 - 4167. [Abstract] [Full Text] [PDF]
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 W. L. Isley Growth Hormone Therapy for Adults: Not Ready for Prime Time? Ann Intern Med, August 6, 2002; 137(3): 190 - 196. [Abstract] [Full Text] [PDF]
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A. F. Attanasio, S. Howell, P. C. Bates, P. Frewer, J. Chipman, W. F. Blum, and S. M. Shalet Body Composition, IGF-I and IGFBP-3 Concentrations as Outcome Measures in Severely GH-Deficient (GHD) Patients after Childhood GH Treatment: A Comparison with Adult Onset GHD Patients J. Clin. Endocrinol. Metab., July 1, 2002; 87(7): 3368 - 3372. [Abstract] [Full Text] [PDF]
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S. Ezzat, S. Fear, R.-C. Gaillard, C. Gayle, H. Landy, S. Marcovitz, T. Mattioni, S. Nussey, A. Rees, and E. Svanberg Gender-Specific Responses of Lean Body Composition and Non-Gender-Specific Cardiac Function Improvement after GH Replacement in GH-Deficient Adults J. Clin. Endocrinol. Metab., June 1, 2002; 87(6): 2725 - 2733. [Abstract] [Full Text] [PDF]
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A. Kehely, P. C. Bates, P. Frewer, M. Birkett, W. F. Blum, P. Mamessier, S. Ezzat, K. K. Y. Ho, G. Lombardi, A. Luger, et al. Short-Term Safety and Efficacy of Human GH Replacement Therapy in 595 Adults with GH Deficiency: A Comparison of Two Dosage Algorithms J. Clin. Endocrinol. Metab., May 1, 2002; 87(5): 1974 - 1979. [Abstract] [Full Text] [PDF]
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A. F. Attanasio, P. C. Bates, K. K. Y. Ho, S. M. Webb, R. J. Ross, C. J. Strasburger, R. Bouillon, B. Crowe, K. Selander, D. Valle, et al. Human Growth Hormone Replacement in Adult Hypopituitary Patients: Long-Term Effects on Body Composition and Lipid Status--3-Year Results from the HypoCCS Database J. Clin. Endocrinol. Metab., April 1, 2002; 87(4): 1600 - 1606. [Abstract] [Full Text] [PDF]
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R. D. Murray, K. H. Darzy, H. K. Gleeson, and S. M. Shalet GH-Deficient Survivors of Childhood Cancer: GH Replacement during Adult Life J. Clin. Endocrinol. Metab., January 1, 2002; 87(1): 129 - 135. [Abstract] [Full Text] [PDF]
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E. M. McConnell, A. B. Atkinson, C. Ennis, D. R. Hadden, D. R. McCance, B. Sheridan, and P. M. Bell The Effects on Insulin Action in Adult Hypopituitarism of Recombinant Human GH Therapy Individually Titrated for Six Months J. Clin. Endocrinol. Metab., November 1, 2001; 86(11): 5342 - 5347. [Abstract] [Full Text] [PDF]
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J. Koranyi, J. Svensson, G. Gotherstrom, K. S. Sunnerhagen, B.-A. Bengtsson, and G. Johannsson Baseline Characteristics and the Effects of Five Years of GH Replacement Therapy in Adults with GH Deficiency of Childhood or Adulthood Onset: A Comparative, Prospective Study J. Clin. Endocrinol. Metab., October 1, 2001; 86(10): 4693 - 4699. [Abstract] [Full Text] [PDF]
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A. P. Goldstone, E. L. Thomas, A. E. Brynes, J. D. Bell, G. Frost, N. Saeed, J. V. Hajnal, J. K. Howard, A. Holland, and S. R. Bloom Visceral Adipose Tissue and Metabolic Complications of Obesity Are Reduced in Prader-Willi Syndrome Female Adults: Evidence for Novel Influences on Body Fat Distribution J. Clin. Endocrinol. Metab., September 1, 2001; 86(9): 4330 - 4338. [Abstract] [Full Text] [PDF]
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W. M. Drake, S. J. Howell, J. P. Monson, and S. M. Shalet Optimizing GH Therapy in Adults and Children Endocr. Rev., August 1, 2001; 22(4): 425 - 450. [Abstract] [Full Text] [PDF]
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L. Wiren, G. Johannsson, and B.-A. Bengtsson A Prospective Investigation of Quality of Life and Psychological Well-Being after the Discontinuation of GH Treatment in Adolescent Patients Who Had GH Deficiency during Childhood J. Clin. Endocrinol. Metab., August 1, 2001; 86(8): 3494 - 3498. [Abstract] [Full Text] [PDF]
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P. Marzullo, C. Di Somma, K. L. Pratt, J. Khosravi, A. Diamandis, G. Lombardi, A. Colao, and R. G. Rosenfeld Usefulness of Different Biochemical Markers of the Insulin-Like Growth Factor (IGF) Family in Diagnosing Growth Hormone Excess and Deficiency in Adults J. Clin. Endocrinol. Metab., July 1, 2001; 86(7): 3001 - 3008. [Abstract] [Full Text] [PDF]
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A. Colao, C. di Somma, A. Cuocolo, L. Spinelli, N. Tedesco, R. Pivonello, D. Bonaduce, M. Salvatore, and G. Lombardi Improved Cardiovascular Risk Factors and Cardiac Performance after 12 Months of Growth Hormone (GH) Replacement in Young Adult Patients with GH Deficiency J. Clin. Endocrinol. Metab., May 1, 2001; 86(5): 1874 - 1881. [Abstract] [Full Text]
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A. L. Barkan The "Quality of Life-Assessment of Growth Hormone Deficiency in Adults" Questionnaire: Can It Be Used to Assess Quality of Life in Hypopituitarism? J. Clin. Endocrinol. Metab., May 1, 2001; 86(5): 1905 - 1907. [Abstract] [Full Text]
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R. Dall, S. Longobardi, C. Ehrnborg, N. Keay, T. Rosén, J. O. L. Jørgensen, R. C. Cuneo, M. A. Boroujerdi, A. Cittadini, R. Napoli, et al. The Effect of Four Weeks of Supraphysiological Growth Hormone Administration on the Insulin-Like Growth Factor Axis in Women and Men J. Clin. Endocrinol. Metab., November 1, 2000; 85(11): 4193 - 4200. [Abstract] [Full Text]
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G. Aimaretti, C. Baffoni, S. Bellone, L. Di Vito, G. Corneli, E. Arvat, L. Benso, F. Camanni, and E. Ghigo Retesting Young Adults with Childhood-Onset Growth Hormone (GH) Deficiency with GH-Releasing-Hormone-Plus-Arginine Test J. Clin. Endocrinol. Metab., October 1, 2000; 85(10): 3693 - 3699. [Abstract] [Full Text]
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G. Sesmilo, B. M.K. Biller, J. Llevadot, D. Hayden, G. Hanson, N. Rifai, and A. Klibanski Effects of Growth Hormone Administration on Inflammatory and Other Cardiovascular Risk Markers in Men with Growth Hormone Deficiency: A Randomized, Controlled Clinical Trial Ann Intern Med, July 18, 2000; 133(2): 111 - 122. [Abstract] [Full Text] [PDF]
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 J. A. M. Beentjes, A. van Tol, W. J. Sluiter, and R. P. F. Dullaart Effect of growth hormone replacement therapy on plasma lecithin:cholesterol acyltransferase and lipid transfer protein activities in growth hormone-deficient adults J. Lipid Res., June 1, 2000; 41(6): 925 - 932. [Abstract] [Full Text]
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N. Vahl, A. Juul, J. O. L. Jørgensen, H. Ørskov, N. E. Skakkebæk, and Jens. S. Christiansen Continuation of Growth Hormone (GH) Replacement in GH-Deficient Patients during Transition from Childhood to Adulthood: A Two-Year Placebo-Controlled Study J. Clin. Endocrinol. Metab., May 1, 2000; 85(5): 1874 - 1881. [Abstract] [Full Text]
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B.-A. Bengtsson and G. Johannsson The Treatment of Growth Hormone Deficiency in Adults J. Clin. Endocrinol. Metab., March 1, 2000; 85(3): 933 - 937. [Full Text]
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B. M. K. Biller, G. Sesmilo, H. B. A. Baum, D. Hayden, D. Schoenfeld, and A. Klibanski Withdrawal of Long-Term Physiological Growth Hormone (GH) Administration: Differential Effects on Bone Density and Body Composition in Men with Adult-Onset GH Deficiency J. Clin. Endocrinol. Metab., March 1, 2000; 85(3): 970 - 976. [Abstract] [Full Text]
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Discontinuation of Growth Hormone (GH) Treatment: Metabolic Effects in GH-Deficient and GH-Sufficient Adolescent Patients Compared with Control Subjects J. Clin. Endocrinol. Metab., December 1, 1999; 84(12): 4516 - 4524. [Abstract] [Full Text]
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 M. L. Vance and N. Mauras Growth Hormone Therapy in Adults and Children N. Engl. J. Med., October 14, 1999; 341(16): 1206 - 1216. [Full Text] [PDF]
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J. Gibney, J. D. Wallace, T. Spinks, L. Schnorr, A. Ranicar, R. C. Cuneo, S. Lockhart, K. G. Burnand, F. Salomon, P. H. Sonksen, et al. The Effects of 10 Years of Recombinant Human Growth Hormone (GH) in Adult GH-Deficient Patients J. Clin. Endocrinol. Metab., August 1, 1999; 84(8): 2596 - 2602. [Abstract] [Full Text]
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J. Khosravi, A. Diamandi, J. Mistry, and R. G. Krishna The High Molecular Weight Insulin-Like Growth Factor-Binding Protein Complex: Epitope Mapping, Immunoassay, and Preliminary Clinical Evaluation J. Clin. Endocrinol. Metab., August 1, 1999; 84(8): 2826 - 2833. [Abstract] [Full Text]
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J. C. ter Maaten, H. de Boer, O. Kamp, L. Stuurman, and E. A. van der Veen Long-Term Effects of Growth Hormone (GH) Replacement in Men with Childhood-Onset GH Deficiency J. Clin. Endocrinol. Metab., July 1, 1999; 84(7): 2373 - 2380. [Abstract] [Full Text]
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A. Hilding, K. Hall, I.-L. Wivall-Helleryd, M. Sääf, A.-L. Melin, and M. Thorén Serum Levels of Insulin-Like Growth Factor I in 152 Patients with Growth Hormone Deficiency, Aged 19-82 Years, in Relation to Those in Healthy Subjects J. Clin. Endocrinol. Metab., June 1, 1999; 84(6): 2013 - 2019. [Abstract] [Full Text]
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A. Colao, G. Cerbone, R. Pivonello, G. Aimaretti, S. Loche, C. Di Somma, A. Faggiano, G. Corneli, E. Ghigo, and G. Lombardi The Growth Hormone (GH) Response to the Arginine Plus GH-Releasing Hormone Test Is Correlated to the Severity of Lipid Profile Abnormalities in Adult Patients with GH Deficiency J. Clin. Endocrinol. Metab., April 1, 1999; 84(4): 1277 - 1282. [Abstract] [Full Text]
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 C. L. Clarson and R. F. Del Maestro Growth Failure After Treatment of Pediatric Brain Tumors Pediatrics, March 1, 1999; 103(3): 37e - 37. [Abstract] [Full Text]
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Y. J. H. Janssen, J. Doornbos, and F. Roelfsema Changes in Muscle Volume, Strength, and Bioenergetics during Recombinant Human Growth Hormone (GH) Therapy in Adults with GH Deficiency J. Clin. Endocrinol. Metab., January 1, 1999; 84(1): 279 - 284. [Abstract] [Full Text]
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E. R. Christ, M. H. Cummings, E. Albany, A. M. Umpleby, P. J. Lumb, A. S. Wierzbicki, R. P. Naoumova, M. A. Boroujerdi, P. H. Sönksen, and D. L. Russell-Jones Effects of Growth Hormone (GH) Replacement Therapy on Very Low Density Lipoprotein Apolipoprotein B100 Kinetics in Patients with Adult GH Deficiency: A Stable Isotope Study J. Clin. Endocrinol. Metab., January 1, 1999; 84(1): 307 - 316. [Abstract] [Full Text]
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A. Sartorio and S. Saraifoger Comments on Adults with Childhood-Onset GH Deficiency: the Psychosocial Adjustment Can Be Negatively Conditioned by a Final "Unsatisfactory" Heightg J. Clin. Endocrinol. Metab., December 1, 1998; 83(12): 4533 - 4534. [Full Text]
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D. E. Sandberg and M. H. MacGillivray Adult Height and Psychological Adaptation--Authors' Responseh J. Clin. Endocrinol. Metab., December 1, 1998; 83(12): 4534 - 4534. [Full Text]
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H. B. A. Baum, L. Katznelson, J. C. Sherman, B. M. K. Biller, D. L. Hayden, D. A. Schoenfeld, K. E. Cannistraro, and A. Klibanski Effects of Physiological Growth Hormone (GH) Therapy on Cognition and Quality of Life in Patients with Adult-Onset GH Deficiency J. Clin. Endocrinol. Metab., September 1, 1998; 83(9): 3184 - 3189. [Abstract] [Full Text]
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M. Christopher, F. L. Hew, M. Oakley, C. Rantzau, and F. Alford Defects of Insulin Action and Skeletal Muscle Glucose Metabolism in Growth Hormone-Deficient Adults Persist after 24 Months of Recombinant Human Growth Hormone Therapy J. Clin. Endocrinol. Metab., May 1, 1998; 83(5): 1668 - 1681. [Abstract] [Full Text]
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S. M. Shalet, A. Toogood, A. Rahim, and B. M. D. Brennan The Diagnosis of Growth Hormone Deficiency in Children and Adults Endocr. Rev., April 1, 1998; 19(2): 203 - 223. [Abstract] [Full Text]
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D. E. Sandberg, M. H. MacGillivray, R. R. Clopper, C. Fung, L. LeRoux, and D. E. Alliger Quality of Life among Formerly Treated Childhood-Onset Growth Hormone-Deficient Adults: A Comparison with Unaffected Siblings J. Clin. Endocrinol. Metab., April 1, 1998; 83(4): 1134 - 1142. [Abstract] [Full Text]
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P. V. Carroll, E. R. Christ the members of Growth Hormone Research Soci, B. A. Bengtsson, L. Carlsson, J. S. Christiansen, D. Clemmons, R. Hintz, K. Ho, Z. Laron, P. Sizonenko, et al. Growth Hormone Deficiency in Adulthood and the Effects of Growth Hormone Replacement: A Review J. Clin. Endocrinol. Metab., February 1, 1998; 83(2): 382 - 395. [Abstract] [Full Text]
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R. C. Cuneo, S. Judd, J. D. Wallace, D. Perry-Keene, H. Burger, S. Lim-Tio, B. Strauss, J. Stockigt, D. Topliss, F. Alford, et al. The Australian Multicenter Trial of Growth Hormone (GH) Treatment in GH-Deficient Adults J. Clin. Endocrinol. Metab., January 1, 1998; 83(1): 107 - 116. [Abstract] [Full Text]
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 S. W. Lamberts, A. W. van den Beld, and A. van der Lely The Endocrinology of Aging Science, October 17, 1997; 278(5337): 419 - 424. [Abstract] [Full Text]
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H. de Boer and E. A. van der Veen Why Retest Young Adults with Childhood-Onset Growth Hormone Deficiency? J. Clin. Endocrinol. Metab., July 1, 1997; 82(7): 2032 - 2036. [Full Text] [PDF]
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