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This version published online on May 19, 2009 Journal of Clinical Endocrinology & Metabolism , doi:10.1210/jc.2008-2786
Submitted on December 23, 2008 Serum 25-hydroxyvitamin D Levels and Rate of Hip Bone Loss in Older MenKristine E. Ensrud MD, MPH*,Center for Chronic Disease Outcomes Research, VA Medical Center, Minneapolis, MN; Department of Medicine and Division of Epidemiology & Community Health, University of Minnesota, Minneapolis, MN; Division of Epidemiology, University of Pittsburgh, Pittsburgh, PA; California Pacific Medical Center Research Institute, San Francisco, CA; Geriatric Research Education and Clinical Center, VA Medical Center, Minneapolis, MN; Departments of Epidemiology and Family & Preventive Medicine, University of California – San Diego, La Jolla, CA; Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA; Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL; Bone and Mineral Unit, Oregon Health & Science University, Portland, OR * To whom correspondence should be addressed. E-mail: ensru001{at}umn.edu.
Context: Vitamin D deficiency is common among older adults, but the association between 25-hydroxyvitamin D (25(OH)D) levels and rates of bone loss is uncertain. Objective: Test the hypothesis that lower 25(OH)D levels are associated with higher rates of hip bone loss in older men. Design: Prospective cohort study Setting: Six U.S. centers Participants: 1279 community-dwelling men aged Main Outcome Measure(s): Annualized percent rate of change in hip BMD Results: After adjustment for multiple potential confounders, the average rate of decline in total hip BMD was -0.59%/year among men with 25(OH)D levels <15.0 ng/mL, -0.54%/year among men with 25(OH)D levels 15.0–19.9 ng/mL, -0.35%/year among men with 25(OH)D levels 20.0–29.9 ng/mL, and -0.37%/year among men with 25(OH)D levels Conclusions: In this cohort of community-dwelling older men, men with 25(OH)D levels <20 ng/mL had greater subsequent rates of hip bone loss, but rates of loss were similar among men with higher levels. These results lend support to the view that low 25(OH)D levels are detrimental to BMD in older men. Key words: 25-hydroxyvitamin D • bone loss • aging
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65 years with 25(OH)D levels (liquid chromatography tandem mass spectroscopy) and hip bone mineral density (BMD) (dual x-ray absorptiometry) at baseline and repeat hip BMD an average of 4.4 years later.
