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Submitted on December 5, 2008
Accepted on June 19, 2009
Hospital La Merced, Osuna, Spain; Facultad de Psicología, Universidad de Málaga, Spain; Servicio de Endocrinología y Nutrición, Hospital General, Jaén, Spain; Facultad de Humanidades y Ciencias de la Educación, Departamento de Psicología, Universidad de Jaén, Spain; Fundación Imabis, Málaga, Spain; CIBER Fisiopatología Obesidad y Nutrición (CB06/03), ISCIII, Málaga, Spain; Laboratorio de Análisis Clínicos. Hospital General, Jaén, Spain; Laboratorio de Hormonas, Hospital Universitario Carlos Haya, Málaga, Spain; Unidad de Investigación, Hospital la Merced, Osuna, Spain; Hospital Punta de Europa de Algeciras, Cádiz, Spain; Servicio de Endocrinología y Nutrición. Hospital Universitario Carlos Haya, Málaga, Spain; CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), ISCIII, Málaga, Spain
* To whom correspondence should be addressed. E-mail: federico.soriguer.sspa{at}juntadeandalucia.es.
Context: The association between thyroid function during pregnancy and the later mental and psychomotor development of the child is supported by numerous experimental, clinical and epidemiological studies.
Objective: To evaluate the psychological development of infants aged 3 to 18 months whose mothers had received 300 µg of potassium iodine during the first trimester of their pregnancy.
Design and Study Subjects: The study included 133 women who had received 300 µg of potassium iodine and 61 women who had received no iodine supplements.
Main Outcome Measures: The neuropsychological status of the children was evaluated with the Bayley Scales of Infant Development and measurements were made of TSH, FT3, FT4 and urinary iodine.
Results: Those children whose mothers had received an iodine supplement of 300 µg had a more favorable psychometric assessment than those of the other group of mothers. They had higher scores on the Psychomotor Development Index (p=0.02) and the Behavior Rating Scale.
Conclusions: Dietary iodine supplements not only have no harmful effect on the neurodevelopment of the children, they may even be beneficial. Given the possible presence of confounding variables not controlled for in this study, these findings should be considered as preliminary.
This article has been cited by other articles:
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  E. N. Pearce What Do We Know about Iodine Supplementation in Pregnancy? J. Clin. Endocrinol. Metab., September 1, 2009; 94(9): 3188 - 3190. [Full Text] [PDF]
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