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Guidelines for Acromegaly Management: An Update

Department of Medicine (S.M.), Cedars-Sinai Medical Center, Los Angeles, California 90048; Department of Molecular and Clinical Endocrinology and Oncology (A.C.), Federico II University of Naples, 80138 Naples, Italy; Division of Endocrinology and Metabolism (A.B.), University of Michigan Medical Center, Ann Arbor, Michigan 48109; Endocrinology Clinic (M.M.), Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611; Department of Endocrinology (A.B.G.), St. Bartholomew’s Hospital, London EC1A 7BE, United Kingdom; Department of Medicine (D.K.), New York University Medical Center, New York, New York 10016; Division of Endocrinology (D.C.), University of North Carolina, Chapel Hill, North Carolina 27599; Assistance Publique-Hôpitaux de Paris (P.C.), Department of Endocrinology and Reproductive Diseases, Hôpital de Bicêtre and Université Paris-Sud 11, Le Kremlin-Bicêtre F-94276, France; Department of Neurosurgery (E.L.), Brigham & Women’s Hospital, Boston, Massachusetts 02115; Department of Internal Medicine (J.S.), University of Iowa, Iowa City, Iowa 52242; Department of Medicine (M.L.V.), University of Virginia, Charlottesville, Virginia 22904; Pituitary Research Unit (K.H.), Garvan Institute of Medical Research, Sydney NSW 2010, Australia; and Department of Internal Medicine (A.G.), University of Brescia, 25121 Brescia, Italy

Address all correspondence and requests for reprints to: S. Melmed, M.D., Cedars-Sinai Research Institute, 8700 Beverly Boulevard, Room 2015, Los Angeles, California 90048.

Objective: The Acromegaly Consensus Group reconvened in November 2007 to update guidelines for acromegaly management.

Participants: The meeting participants comprised 68 pituitary specialists, including neurosurgeons and endocrinologists with extensive experience treating patients with acromegaly.

Evidence/Consensus Process: Goals of treatment and the appropriate imaging and biochemical and clinical monitoring of patients with acromegaly were enunciated, based on the available published evidence.

Conclusions: The group developed a consensus on the approach to managing acromegaly including appropriate roles for neurosurgery, medical therapy, and radiation therapy in the management of these patients.

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