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Vitamin D Status and Muscle Function in Post-Menarchal Adolescent Girls

Imaging Science and Biomedical Engineering (K.A.W., J.E.A.), and Health Methodology Research Group (S.A.R.), University of Manchester, Manchester M13 9PT, United Kingdom; Central Manchester Primary Care Trust (G.D.), Longsight Health Centre, Longsight, Manchester M13 0RR, United Kingdom; Vitamin D Research Group (J.L.B.), Medicine, University of Manchester, Manchester Royal Infirmary, Manchester M13 9WL, United Kingdom; Novotec Medical GmbH (R.R.), D-75172 Pforzheim, Germany; and Department of Paediatric Medicine (Z.M.), Saint Mary’s Hospital for Women & Children, Central Manchester & Manchester Children’s Hospitals National Health Service Trust, Manchester M13 0JH, United Kingdom

Address all correspondence and requests for reprints to: Dr. Kate Ward, Nutrition and Bone Health Research Group, Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, United Kingdom. E-mail: Kate.Ward{at}mrc-hnr.cam.ac.uk.

Context: There has been a resurgence of vitamin D deficiency among infants, toddlers, and adolescents in the United Kingdom. Myopathy is an important clinical symptom of vitamin D deficiency, yet it has not been widely studied.

Objective: Our objective was to investigate the relationship of baseline serum 25 hydroxyvitamin D [25(OH)D] concentration and PTH with muscle power and force.

Design: This was a cross-sectional study.

Setting: The study was community based in a secondary school.

Participants: A total of 99 post-menarchal 12- to 14-yr-old females was included in the study.

Main Outcome Measures: Jumping mechanography to measure muscle power, velocity, jump height, and Esslinger Fitness Index from a two-legged counter movement jump and force from multiple one-legged hops was performed. Body height, weight, and serum concentrations of 25(OH)D, PTH, and calcium were measured.

Results: Median serum 25(OH)D concentration was 21.3 nmol/liter (range 2.5–88.5) and PTH 3.7 pmol/liter (range 0.47–26.2). After correction for weight using a quadratic function, there was a positive relationship between 25(OH)D and jump velocity (P = 0.002), jump height (P = 0.005), power (P = 0.003), Esslinger Fitness Index (P = 0.003), and force (P = 0.05). There was a negative effect of PTH upon jump velocity (P = 0.04).

Conclusion: From these data we conclude that vitamin D was significantly associated with muscle power and force in adolescent girls.

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