help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2008-0567
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Data
Right arrow All Versions of this Article:
93/9/3478    most recent
Author Manuscript (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Google Scholar
Right arrow Articles by Sowers, M. R.
Right arrow Articles by Randolph, J. F.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sowers, M. R.
Right arrow Articles by Randolph, J. F., Jr.
Related Collections
Right arrow Neuroendocrinology and Pituitary
Right arrow Female Endocrinology
The Journal of Clinical Endocrinology & Metabolism Vol. 93, No. 9 3478-3483
Copyright © 2008 by The Endocrine Society

Anti-Mullerian Hormone and Inhibin B in the Definition of Ovarian Aging and the Menopause Transition

MaryFran R. Sowers, Aimee D. Eyvazzadeh, Daniel McConnell, Matheos Yosef, Mary L. Jannausch, Daowen Zhang, Sioban Harlow and John F. Randolph, Jr.

Department of Epidemiology (M.F.R.S., D.M., M.Y., M.L.J., S.H.), School of Public Health, University of Michigan 48109, and Department of Obstetrics and Gynecology (M.F.R.S., A.D.E., J.F.R.), University of Michigan Health Sciences System, Ann Arbor, Michigan 48109; and Department of Statistics (D.Z.), North Carolina State University, Raleigh, North Carolina 27695

Address all correspondence and requests for reprints to: MaryFran Sowers, Ph.D., Department of Epidemiology, School of Public Health, University of Michigan, 109 Observatory, Room 1846, Ann Arbor, Michigan 48109. E-mail: mfsowers{at}umich.edu.

Context/Objective: The objective of the study was to determine whether anti-Mullerian hormone (AMH) and inhibin B are viable endocrine biomarkers for framing the menopause transition from initiation to the final menstrual period (FMP).

Design: We assayed AMH, inhibin B, and FSH in 300 archival follicular phase specimens from 50 women with six consecutive annual visits commencing in 1993 when all women were in the pre- and perimenopausal menopause stages. Subsequently each woman had a documented FMP. The assay results were fitted as individual-woman profiles and then related to time to FMP and age at FMP as outcomes.

Results: Based on annual values from six time points prior to the FMP, logAMH longitudinal profiles declined and were highly associated with a time point 5 yr prior to FMP [including both observed and values below detection (P < 0.0001 and P = 0.0001, respectively)]. Baseline AMH profiles were also associated with age at FMP (P = 0.035). Models of declining loginhibin B profiles (including both observed and values below detection) were associated with time to FMP (P < 0.0001 and P = 0.0003, respectively). There was no significant association of loginhibin B profiles with age at FMP.

Conclusions: AMH, an endocrine marker that reflects the transition of resting primordial follicles to growing follicles, declined to a time point 5 yr prior to the FMP; this may represent a critical biological juncture in the menopause transition. Low and nondetectable levels inhibin B levels also were observed 4–5 yr prior to the FMP but were less predictive of time to FMP or age at FMP.




This article has been cited by other articles:


Home page
J. Clin. Endocrinol. Metab.Home page
M. R. Sowers, H. Zheng, D. McConnell, B. Nan, S. Harlow, and J. F. Randolph Jr.
Follicle Stimulating Hormone and Its Rate of Change in Defining Menopause Transition Stages
J. Clin. Endocrinol. Metab., October 1, 2008; 93(10): 3958 - 3964.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2008 by The Endocrine Society