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Improved Peripheral Cortical Bone Geometry after Surgical Treatment of Primary Hyperparathyroidism in Postmenopausal Women

Division of Diabetes, Metabolism, and Endocrinology (H.K., R.N.), Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan; and Internal Medicine 1 (M.Y., T.S.), Shimane University Faculty of Medicine, Shimane 693-8501, Japan

Address all correspondence and requests for reprints to: Hiroshi Kaji, Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan. E-mail: hiroshik{at}med.kobe-u.ac.jp.

Context: Cortical bone geometry is one of the most important components of bone strength. Excess endogenous PTH or intermittent PTH administration affects cortical bone geometry; however, the changes in cortical bone geometry in patients with primary hyperparathyroidism (pHPT) after parathyroidectomy (PTX) remain unknown.

Objective: The present study was performed to examine the longitudinal effects of treating endogenous PTH excess on cortical bone geometry in postmenopausal patients with pHPT by using peripheral quantitative computed tomography.

Patients: Twenty postmenopausal pHPT patients and 30 postmenopausal control subjects matched for age participated in this study.

Main Outcome Measures: Volumetric bone mineral density (vBMD), cortical bone geometric parameters, polar strength strain index, and polar cross-sectional moment of inertia were measured using peripheral quantitative computed tomography at the radius during the year after PTX.

Results: After 1 yr, total and cortical vBMD significantly increased after PTX in the pHPT group (2.9 and 1.6%, respectively), whereas they significantly decreased in the control group (–2.1 and –1.3%, respectively). Significant decreases in cortical thickness and area were observed in the control group (–3.0 and –2.5%, respectively). In contrast, the pHPT group showed increases in cortical thickness and area (8.5 and 7.6%, respectively) as well as polar strength strain index 1 year after PTX.

Conclusion: The present longitudinal study showed significant beneficial changes in volumetric BMD, cortical bone geometry, and bone strength index after PTX in postmenopausal women with pHPT.