help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2008-0007
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
93/7/2904    most recent
Author Manuscript (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Google Scholar
Right arrow Articles by Berentzen, T.
Right arrow Articles by Sørensen, T. I. A.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Berentzen, T.
Right arrow Articles by Sørensen, T. I. A.
Related Collections
Right arrow Metabolism
Right arrow Obesity
The Journal of Clinical Endocrinology & Metabolism Vol. 93, No. 7 2904-2908
Copyright © 2008 by The Endocrine Society


BRIEF REPORT

Lack of Association of Fatness-Related FTO Gene Variants with Energy Expenditure or Physical Activity

T. Berentzen, S. I. I. Kring, C. Holst, E. Zimmermann, T. Jess, T. Hansen, O. Pedersen, S. Toubro, A. Astrup and T. I. A. Sørensen

Institute of Preventive Medicine (T.B., S.I.I.K., C.H., E.Z., T.J., T.I.A.S.), Copenhagen University Hospitals, Centre for Health and Society, DK-1357 Copenhagen, Denmark; Center for Pharmacogenomics (S.I.I.K.), the Panum Institute, DK-2200 Copenhagen, Denmark, and Department of Human Nutrition (A.A.), Faculty of Life Sciences, University of Copenhagen, DK-1958 Fredericksburg, Denmark; Steno Diabetes Centre (T.H., O.P.), DK-2820 Gentofte, Denmark; Faculty of Health Science (O.P.), University of Aarhus, DK-8000 Aarhus, Denmark; and Reduce-Research Clinic of Nutrition (S.T.), Hvidovre University Hospital, DK-2650 Hvidovre, Denmark

Address all correspondence and requests for reprints to: Tina Berentzen, Institute of Preventive Medicine, Øster Søgade 18, Copenhagen K, DK-1357, Denmark. E-mail: tb{at}ipm.regionh.dk.

Context: A common variant in the first intron of FTO (rs9939609, T/A) is associated with fatness in Caucasians.

Objective: FTO may regulate energy homeostasis through the hypothalamus, and we hypothesized that AA-genotypes of rs9939609 FTO have lower energy expenditure and/or a lower level of physical activity.

Methods: The study population included all obese young men (body mass index ≥ 31 kg/m2) at the mandatory draft board examinations in the Copenhagen area from 1943 to 1977 and a randomly selected control group from this population. Subgroups of 234 obese and 323 controls were examined in 1998–2000 (median age 48 yr). Fat mass (FM), lean body mass (LBM), leisure-time physical activity (LTPA), maximum oxygen uptake (VO2max), resting energy expenditure (REE), and glucose-induced thermogenesis (GIT) were measured. The FTO rs9939609 variant was genotyped. A recessive transmission mode fit the data best. Logistic regression was used to assess the odds ratios of the AA-genotype in relation to LTPA, VO2max, REE, and GIT.

Results: The AA-genotype of FTO rs9939609 had higher REE in the age-adjusted model, but the association was eliminated when adjusting for FM and LBM. The AA-genotype was not associated with LTPA, VO2max, or GIT. This was not influenced by adjustment for age, FM, or LBM. The AA-genotype had increased FM, even with adjustment for age, LBM, REE, GIT, VO2max, and LTPA. Results were similar for FTO rs8050136 and rs7193144.

Conclusions: Homozygous carriers of the A-allele of rs9939609 FTO do not have lower REE, GIT, VO2max, or LTPA but higher FM, irrespective of LBM, REE, GIT, VO2max, and LTPA.







HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2008 by The Endocrine Society