help button home button Endocrine Society JCEM JCEM Call for Nominations for EIC
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2007-2177
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
93/5/1834    most recent
Author Manuscript (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow View responses
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Google Scholar
Right arrow Articles by Grossmann, M.
Right arrow Articles by Jerums, G.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Grossmann, M.
Right arrow Articles by Jerums, G.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Medline Plus Health Information
*Diabetes
Hazardous Substances DB
*TESTOSTERONE
Related Collections
Right arrow Diabetes and Insulin
Right arrow Male Endocrinology
The Journal of Clinical Endocrinology & Metabolism Vol. 93, No. 5 1834-1840
Copyright © 2008 by The Endocrine Society

Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes

Mathis Grossmann, Merlin C. Thomas, Sianna Panagiotopoulos, Ken Sharpe, Richard J. MacIsaac, Sophie Clarke, Jeffrey D. Zajac and George Jerums

Department of Endocrinology and Medicine (M.G., M.C.T., S.P., R.J.M., S.C., J.D.Z., G.J.), University of Melbourne, Austin Health, Heidelberg, Victoria 3084, Australia; Baker Heart Research Institute (M.C.T.), Melbourne, Victoria 3004, Australia; and Department of Mathematics and Statistics (K.S.), University of Melbourne, Victoria 3010, Australia

Address all correspondence and requests for reprints to: Dr. Mathis Grossmann, FRACP, M.D., Ph.D., Department of Medicine and Endocrinology, University of Melbourne, Austin Health, Level 7, Lance Townsend Building, Studley Road, Heidelberg, VIC 3084 Australia. E-mail: mathisg{at}unimelb.edu.au.

Context: Low testosterone levels are common in men with type 2 diabetes and may be associated with insulin resistance.

Objective: We investigated prevalence of testosterone deficiency and the relationship between testosterone and insulin resistance in a large cohort of men with type 2 and type 1 diabetes.

Design: The study was a cross-sectional survey of 580 men with type 2 diabetes and 69 men with type 1 diabetes. A subgroup of 262 men with type 2 diabetes was then reassessed after a median of 6 months.

Results: Forty-three percent of men with type 2 diabetes had a reduced total testosterone, and 57% had a reduced calculated free testosterone. Only 7% of men with type 1 diabetes had low total testosterone. By contrast, 20.3% of men with type 1 diabetes had low calculated free testosterone, similar to that observed in type 2 diabetes (age-body mass index adjusted odds ratio = 1.4; 95% confidence interval = 0.7–2.9). Low testosterone levels were independently associated with insulin resistance in men with type 1 diabetes as well as type 2 diabetes. Serial measurements also revealed an inverse relationship between changes in testosterone levels and insulin resistance.

Conclusions: Testosterone deficiency is common in men with diabetes, regardless of the type. Testosterone levels are partly influenced by insulin resistance, which may represent an important avenue for intervention, whereas the utility of testosterone replacement remains to be established in prospective trials.




eLetters:

Read all eLetters

Relation of BMI with testosterone in type 1 and type 2 diabetes
Paresh Dandona, et al.
JCEM Online, 30 Apr 2008 [Full text]
Low testosterone levels in men with type 1 diabetes
Mathis Grossmann, et al.
JCEM Online, 27 May 2008 [Full text]



HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2008 by The Endocrine Society