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Vitamin D Status and Calcium Metabolism in Adolescent Black and White Girls on a Range of Controlled Calcium Intakes

Departments of Foods and Nutrition (C.M.W., M.B., B.R.M.) and Statistics (G.P.M., L.D.M.), Purdue University, West Lafayette, Indiana 47907; and Indiana University School of Medicine (L.A.D., M.P.), Indianapolis, Indiana 46202

Address all correspondence and requests for reprints to: Connie M. Weaver, Ph.D., Purdue University, Foods and Nutrition, 700 West State Street, West Lafayette, Indiana 47907-2059. E-mail: weavercm{at}purdue.edu.

Background: There are limited data in adolescents on racial differences in relationships between dietary calcium intake, absorption, and retention and serum levels of calcium-regulating hormones.

Objectives: The aim of this study was to investigate these relationships cross-sectionally in American White and Black adolescent girls.

Methods: Calcium balance studies were conducted in 105 girls, aged 11–15 yr, on daily calcium intakes ranging from 760–2195 mg for 3-wk controlled feeding periods; 158 observations from 52 Black and 53 White girls were analyzed.

Results: Black girls had lower serum 25-hydroxyvitamin D [25(OH)D], higher serum 1,25-dihydroxyvitamin D, and higher calcium absorption and retention than White girls. Calcium intake and race, but not serum 25(OH)D, predicted net calcium absorption and retention with Black girls absorbing calcium more efficiently at low calcium intakes than White girls. The relationship between serum 25(OH)D and serum PTH was negative only in White girls. Calcium intake, race, and postmenarcheal age explained 21% of the variation in calcium retention, and serum 25(OH)D did not contribute further to the variance.

Conclusions: These results suggest that serum 25(OH)D does not contribute to the racial differences in calcium absorption and retention during puberty.

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