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Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2006-1438
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The Journal of Clinical Endocrinology & Metabolism Vol. 92, No. 8 3334-3337
Copyright © 2007 by The Endocrine Society

BRIEF REPORT

Water Drinking Induces Thermogenesis through Osmosensitive Mechanisms

Michael Boschmann, Jochen Steiniger, Gabriele Franke, Andreas L. Birkenfeld, Friedrich C. Luft and Jens Jordan

Franz-Volhard Clinical Research Center and Helios-Klinikum-Berlin, Charité Campus Buch, Universitary Medicine Berlin, D-13125 Berlin, Germany

Address all correspondence and requests for reprints to: Jens Jordan, M.D., Franz Volhard Clinical Research Center, Charité Campus Buch, Universitary Medicine Berlin, Wiltbergstrasse 50, Hs. 129, D-13125 Berlin, Germany. E-mail: jens.jordan{at}charite.de.

Context: Recently, we showed that drinking 500 ml water induces thermogenesis in normal-weight men and women.

Objective: We now repeated these studies in a randomized, controlled, crossover trial in overweight or obese otherwise healthy subjects (eight men and eight women), comparing also the effects of 500 ml isoosmotic saline or 50 ml water.

Results: Only 500 ml water increased energy expenditure by 24% over the course of 60 min after ingestion, whereas isoosmotic saline and 50 ml water had no effect. Heart rate and blood pressure did not change in these young, healthy subjects.

Conclusions: Our data exclude volume-related effects or gastric distension as the mediator of the thermogenic response to water drinking. Instead, we hypothesize the existence of a portal osmoreceptor, most likely an ion channel.




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