help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Journal of Clinical Endocrinology & Metabolism , doi:10.1210/jc.2007-0510
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mebis, L.
Right arrow Articles by Van den Berghe, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mebis, L.
Right arrow Articles by Van den Berghe, G.
Related Collections
Right arrow Thyroid
Right arrow Metabolism
The Journal of Clinical Endocrinology & Metabolism Vol. 92, No. 8 3330-3333
Copyright © 2007 by The Endocrine Society

BRIEF REPORT

The Type II Iodothyronine Deiodinase Is Up-Regulated in Skeletal Muscle during Prolonged Critical Illness

Liese Mebis, Lies Langouche, Theo J. Visser and Greet Van den Berghe

Department of Intensive Care Medicine (L.M., L.L., G.V.d.B.), Katholieke Universiteit Leuven, B-3000 Leuven, Belgium; and Department of Internal Medicine (T.J.V.), Erasmus University Medical Center, 3015 GE Rotterdam, The Netherlands

Address all correspondence and requests for reprints to: Greet Van den Berghe, M.D., Ph.D., Department of Intensive Care Medicine, Catholic University of Leuven, B-3000 Leuven, Belgium. E-mail: greet.vandenberghe{at}med.kuleuven.be.

Context: Critical illness is associated with the low T3 syndrome. It remains unclear whether altered type II deiodinase activity (D2) in skeletal muscle contributes to this syndrome.

Objective: Our objective was to study D2 expression and activity in skeletal muscle of acute and prolonged critically ill patients.

Design and Setting: We conducted a clinical observational study in acute and prolonged critical illness with comparison with healthy controls at a university hospital surgical intensive care unit.

Patients: Subjects included 63 prolonged critically ill patients who died in the intensive care unit, 21 acutely ill patients, and 38 controls matched for age, gender, and body mass index.

Results: Elevated expression of the D2 gene and D2 activity in skeletal muscle of prolonged, but not acute, critically ill patients were observed in the face of low circulating thyroid hormone levels.

Conclusions: Reduced D2 activity does not appear to play a role in the pathogenesis of the low T3 syndrome of critical illness.




This article has been cited by other articles:


Home page
 J EndocrinolHome page
J Kwakkel, H C van Beeren, M T Ackermans, M C Platvoet-ter Schiphorst, E Fliers, W M Wiersinga, and A Boelen
Skeletal muscle deiodinase type 2 regulation during illness in mice
J. Endocrinol., November 1, 2009; 203(2): 263 - 270.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
L. Mebis, D. Paletta, Y. Debaveye, B. Ellger, L. Langouche, A. D'Hoore, V. M Darras, T. J Visser, and G. Van den Berghe
Expression of thyroid hormone transporters during critical illness
Eur. J. Endocrinol., August 1, 2009; 161(2): 243 - 250.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
K. A. Heemstra, M. R. Soeters, E. Fliers, M. J. Serlie, J. Burggraaf, M. B. van Doorn, A. A. van der Klaauw, J. A. Romijn, J. W. Smit, E. P. Corssmit, et al.
Type 2 Iodothyronine Deiodinase in Skeletal Muscle: Effects of Hypothyroidism and Fasting
J. Clin. Endocrinol. Metab., June 1, 2009; 94(6): 2144 - 2150.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
B. W. Kim and A. C. Bianco
For Some, L-Thyroxine Replacement Might Not Be Enough: A Genetic Rationale
J. Clin. Endocrinol. Metab., May 1, 2009; 94(5): 1521 - 1523.
[Full Text] [PDF]

Home page
 EndocrinologyHome page
R. Grozovsky, S. Ribich, M. L. Rosene, M. A. Mulcahey, S. A. Huang, M. E. Patti, A. C. Bianco, and B. W. Kim
Type 2 Deiodinase Expression Is Induced by Peroxisomal Proliferator-Activated Receptor-{gamma} Agonists in Skeletal Myocytes
Endocrinology, April 1, 2009; 150(4): 1976 - 1983.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Boelen, J. Kwakkel, C. W. Wieland, D. L. St. Germain, E. Fliers, and A. Hernandez
Impaired Bacterial Clearance in Type 3 Deiodinase-Deficient Mice Infected with Streptococcus pneumoniae
Endocrinology, April 1, 2009; 150(4): 1984 - 1990.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. L. St. Germain, V. A. Galton, and A. Hernandez
Defining the Roles of the Iodothyronine Deiodinases: Current Concepts and Challenges
Endocrinology, March 1, 2009; 150(3): 1097 - 1107.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
B. Gereben, A. M. Zavacki, S. Ribich, B. W. Kim, S. A. Huang, W. S. Simonides, A. Zeold, and A. C. Bianco
Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling
Endocr. Rev., December 1, 2008; 29(7): 898 - 938.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
J Kwakkel, O Chassande, H C van Beeren, W M Wiersinga, and A Boelen
Lacking thyroid hormone receptor {beta} gene does not influence alterations in peripheral thyroid hormone metabolism during acute illness
J. Endocrinol., April 1, 2008; 197(1): 151 - 158.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2007 by The Endocrine Society