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Journal of Clinical Endocrinology & Metabolism , doi:10.1210/jc.2007-0510
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The Journal of Clinical Endocrinology & Metabolism Vol. 92, No. 8 3330-3333
Copyright © 2007 by The Endocrine Society


BRIEF REPORT

The Type II Iodothyronine Deiodinase Is Up-Regulated in Skeletal Muscle during Prolonged Critical Illness

Liese Mebis, Lies Langouche, Theo J. Visser and Greet Van den Berghe

Department of Intensive Care Medicine (L.M., L.L., G.V.d.B.), Katholieke Universiteit Leuven, B-3000 Leuven, Belgium; and Department of Internal Medicine (T.J.V.), Erasmus University Medical Center, 3015 GE Rotterdam, The Netherlands

Address all correspondence and requests for reprints to: Greet Van den Berghe, M.D., Ph.D., Department of Intensive Care Medicine, Catholic University of Leuven, B-3000 Leuven, Belgium. E-mail: greet.vandenberghe{at}med.kuleuven.be.

Context: Critical illness is associated with the low T3 syndrome. It remains unclear whether altered type II deiodinase activity (D2) in skeletal muscle contributes to this syndrome.

Objective: Our objective was to study D2 expression and activity in skeletal muscle of acute and prolonged critically ill patients.

Design and Setting: We conducted a clinical observational study in acute and prolonged critical illness with comparison with healthy controls at a university hospital surgical intensive care unit.

Patients: Subjects included 63 prolonged critically ill patients who died in the intensive care unit, 21 acutely ill patients, and 38 controls matched for age, gender, and body mass index.

Results: Elevated expression of the D2 gene and D2 activity in skeletal muscle of prolonged, but not acute, critically ill patients were observed in the face of low circulating thyroid hormone levels.

Conclusions: Reduced D2 activity does not appear to play a role in the pathogenesis of the low T3 syndrome of critical illness.




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