This Article Full Text Full Text (PDF) All Versions of this Article: 92/5/1809    most recent Author Manuscript (PDF) Submit a related Letter to the Editor Purchase Article View Shopping Cart Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Shaibi, G. Q. Articles by Goran, M. I. Search for Related Content PubMed PubMed Citation Articles by Shaibi, G. Q. Articles by Goran, M. I. Related Collections Metabolism Obesity Pediatric Endocrinology

Adiponectin Independently Predicts Metabolic Syndrome in Overweight Latino Youth

College of Nursing and Healthcare Innovation (G.Q.S.), Arizona State University, Phoenix, Arizona 85069; College of Health Sciences (M.L.C.), University of Texas at El Paso, El Paso, Texas 79968; and Departments of Pediatrics (M.J.W.), Preventive Medicine (C.M.T.-C., C.J.L., L.A.K., J.N.D., C.K., E.E.V., C.K.R., M.I.G.), and Physiology and Biophysics (M.I.G.), Keck School of Medicine, University of Southern California, Los Angeles, California 90033

Address all correspondence and requests for reprints to: Michael I. Goran, Ph.D., Departments of Preventive Medicine and Physiology and Biophysics, University of Southern California, 2250 Alcazar Street, Los Angeles, California 90089-9008. E-mail: goran{at}usc.edu.

Context: Adiponectin may be important in the pathogenesis of insulin resistance and the metabolic syndrome in youth.

Objective: The objective of the study was to determine the unique effect of adiponectin on the metabolic syndrome in overweight Latino youth.

Participants: Participants included 175 overweight children (aged 11.1 ± 1.7 yr, body mass index percentile 97.3 ± 2.9) with a family history of type 2 diabetes.

Methods: Metabolic syndrome was defined according to a pediatric adaptation of the Adult Treatment Panel III report and included dyslipidemia, abdominal obesity, elevated blood pressure, and prediabetes (impaired fasting glucose or impaired glucose tolerance from a 2-h oral glucose tolerance test). Body composition was estimated via dual-energy x-ray absorptiometry, insulin sensitivity was quantified by the frequently sampled iv glucose tolerance test, visceral fat was measured using magnetic resonance imaging, and adiponectin was determined in fasting serum.

Results: In simple linear regression, adiponectin was significantly and inversely related to systolic blood pressure (P < 0.05), waist circumference (P < 0.001), triglycerides (P < 0.001), and 2-h glucose levels (P < 0.05) and positively related to high-density lipoprotein-cholesterol (P < 0.001). In multiple linear regression, adiponectin was significantly related to triglycerides (P < 0.01) and high-density lipoprotein-cholesterol (P < 0.01) independent of age, gender, Tanner stage, body composition, and insulin sensitivity. Analyses of covariance established that adiponectin levels were approximately 25% higher in healthy overweight youth, compared with those with the metabolic syndrome (12.5 ± 3.5 vs. 9.4 ± 2.8 µg/ml; P < 0.05). In multiple logistic regression, adiponectin was a significant independent predictor of the metabolic syndrome, even after adjustment for confounders including insulin sensitivity and visceral fat.

Conclusions: Hypoadiponectinemia is an independent biomarker of the metabolic syndrome, and thus, adiponectin may play a role in the pathophysiology of the disorder in overweight youth.

This article has been cited by other articles:

				Y. Liu, R. Retnakaran, A. Hanley, R. Tungtrongchitr, C. Shaw, and G. Sweeney Total and High Molecular Weight But Not Trimeric or Hexameric Forms of Adiponectin Correlate with Markers of the Metabolic Syndrome and Liver Injury in Thai Subjects J. Clin. Endocrinol. Metab., November 1, 2007; 92(11): 4313 - 4318. [Abstract] [Full Text] [PDF]