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Identifying Children at Risk for Polycystic Ovary Syndrome

The University of Chicago Pritzker School of Medicine, Departments of Pediatrics and Medicine, Section of Pediatric Endocrinology, The University of Chicago Comer Children’s Hospital, Chicago, Illinois 60637

Address all correspondence and requests for reprints to: Robert L. Rosenfield, M.D., The University of Chicago Pritzker School of Medicine, Department of Pediatrics, Section of Pediatric Endocrinology, The University of Chicago Comer Children’s Hospital, 5841 South Maryland Avenue, MC-5053, Chicago, Illinois 60637. E-mail: robros{at}peds.bsd.uchicago.edu.

Context: Polycystic ovary syndrome (PCOS) appears to arise as a complex trait with contributions from both heritable and nonheritable factors. Polygenic influences appear to account for about 70% of the variance in pathogenesis. In view of this evidence for congenital contributions to the syndrome, childhood manifestations may be expected.

Objective: The objective has been to review the evidence that risk factors for PCOS can be recognized in childhood.

Design: This study consisted of screening of the PCOS literature for articles pertaining to potential childhood and adolescent antecedents.

Results: Congenital virilizing disorders; above average or low birth weight for gestational age; premature adrenarche, particularly exaggerated adrenarche; atypical sexual precocity; or intractable obesity with acanthosis nigricans, metabolic syndrome, and pseudo-Cushing syndrome or pseudo-acromegaly in early childhood have been identified as independent prepubertal risk factors for the development of PCOS. During adolescence, PCOS may masquerade as physiological adolescent anovulation. Asymptomatic adolescents with a polycystic ovary occasionally (8%) have subclinical PCOS but often (42%) have a subclinical PCOS type of ovarian dysfunction, the prognosis for which is unclear.

Conclusion: Identifying children at risk for PCOS offers the prospect of eventually preventing some of the long-term complications associated with this syndrome once our understanding of the basis of the disorder improves.

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