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School-Based Intervention Acutely Improves Insulin Sensitivity and Decreases Inflammatory Markers and Body Fatness in Junior High School Students

New York Presbyterian Hospital (M.R., M.H., I.F., I.V., P.K.), New York, New York 10028; and St. Luke’s/Roosevelt Hospital (C.N., R.W.), New York, New York 10025

Address all correspondence and requests for reprints to: Michael Rosenbaum, M.D., Russ Berrie Medical Science Pavilion, 6th Floor, 1150 St. Nicholas Avenue, New York, New York 10032. E-mail: mr475{at}columbia.edu.

Context: Risk factors for type 2 diabetes mellitus (T2DM) include obesity, family history, dyslipidemia, a proinflammatory state, impaired insulin secretory capacity, and insulin resistance.

Objective: The aim of this study was to examine the effects of a 3- to 4-month school-based intervention consisting of health, nutrition, and exercise classes plus an aerobic exercise program on diabetes risk.

Design: This study was a randomized before/after controlled trial.

Methods: Seventy-three eighth-grade students in a predominantly Hispanic New York City public school were divided into a control group (studied twice without receiving the intervention) and an experimental group (studied before and after the intervention).

Outcome Measures: We measured body fatness (bioelectrical impedance), insulin sensitivity, ß-cell function (insulin release in response to an iv glucose load corrected for insulin sensitivity), lipid profiles, and circulating concentrations of IL-6, C-reactive protein, adiponectin, and TNF-.

Results: Participation in the intervention was associated with significant reductions in body fatness, insulin resistance, and circulating concentrations of C-reactive protein and IL-6, irrespective of somatotype on enrollment.

Conclusion: Short-term school-based health, nutrition, and exercise intervention is beneficial to all students and affects multiple diabetes risk factors.

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School-Based Program Reduces Diabetes Risks

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				P. Zeitler School-Based Intervention to Reduce Obesity and Diabetes Risks: Small Steps for a Big Problem J. Clin. Endocrinol. Metab., February 1, 2007; 92(2): 422 - 424. [Full Text] [PDF]