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Effect of Macronutrient Composition on Postprandial Peptide YY Levels

Departments of Internal Medicine (P.A.E., J.E.N.) and Obstetrics and Gynecology (J.E.N.) and General Clinical Research Center (S.N.S., S.M.K.), Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298-0111; and Department of Internal Medicine, McGuire Veterans Affairs Medical Center (J.R.L.), Richmond, Virginia 23249

Address all correspondence and requests for reprints to: Paulina A. Essah, M.D., Virginia Commonwealth University, P.O. Box 980111, Richmond, Virginia 23298-0111. E-mail: pessah{at}mcvh-vcu.edu.

Background: Peptide YY (PYY) is released from the distal small intestine and colon after meals and reduces appetite by increasing satiety. The amount of PYY released is proportional to calories ingested. Fat ingestion has also been reported to stimulate PYY release.

Objective: The objective of the study was to determine whether macronutrient composition influences postprandial serum PYY levels by comparing 1 wk of a weight-maintenance low-carbohydrate, high-fat (LCHF) diet with a low-fat, high-carbohydrate (LFHC) diet.

Methods: In this randomized crossover study, 18 obese subjects (14 females, 4 males, mean body mass index 35.6 ± 2.9 kg/m²) were randomly assigned initially to 1 wk of a weight-maintenance LCHF or LFHC diet, after which a test meal of identical composition was given and serum PYY levels were assessed for 2.5 h postprandially. After a 1-wk washout period, subjects were crossed over and retested.

Results: After 1 wk, mean postprandial area under the curve PYY after the LCHF test meal was 1.5-fold greater than after the LFHC test meal (P < 0.001). The LCHF diet led to 55% higher levels of postprandial serum PYY levels, compared with the LFHC diet (P = 0.005).

Conclusions: These data show that a LCHF diet stimulates PYY secretion more than a LFHC diet in obese individuals.

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