help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Journal of Clinical Endocrinology & Metabolism , doi:10.1210/jc.2006-1371
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Reprints, Permissions and Rights
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cust, A. E.
Right arrow Articles by Riboli, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cust, A. E.
Right arrow Articles by Riboli, E.
Related Collections
Right arrow Endocrine Oncology
Right arrow Female Endocrinology
Right arrow Obesity
The Journal of Clinical Endocrinology & Metabolism Vol. 92, No. 1 255-263
Copyright © 2007 by The Endocrine Society

Plasma Adiponectin Levels and Endometrial Cancer Risk in Pre- and Postmenopausal Women

Anne E. Cust, Rudolf Kaaks, Christine Friedenreich, Fabrice Bonnet, Martine Laville, Annekatrin Lukanova, Sabina Rinaldi, Laure Dossus, Nadia Slimani, Eva Lundin, Anne Tjønneland, Anja Olsen, Kim Overvad, Françoise Clavel-Chapelon, Sylvie Mesrine, Virginie Joulin, Jakob Linseisen, Sabine Rohrmann, Tobias Pischon, Heiner Boeing, Dimitrios Trichopoulos, Antonia Trichopoulou, Vassiliki Benetou, Domenico Palli, Franco Berrino, Rosario Tumino, Carlotta Sacerdote, Amalia Mattiello, J. Ramón Quirós, Michelle A. Mendez, María-José Sánchez, Nerea Larrañaga, M. J. Tormo, Eva Ardanaz, H. Bas Bueno-de-Mesquita, Petra H. M. Peeters, Carla H. van Gils, Kay-Tee Khaw, Sheila Bingham, Naomi Allen, Tim Key, Mazda Jenab and Elio Riboli

Nutrition and Hormones Unit (A.E.C., R.K., S.Ri., L.D., N.S., M.J.), International Agency for Research on Cancer, 69372 Lyon, France; School of Public Health (A.E.C.), University of Sydney, Sydney 2006, Australia; Université Claude Bernard Lyon 1 (A.E.C.), 69622 Lyon, France; Division of Population Health and Information (C.F.), Alberta Cancer Board, Calgary, Alberta, Canada T2N 4N2; Center for Research in Human Nutrition Rhône-Alpes (F.Bo., M.L.), University of Lyon 1, 69622 Lyon, France; Unité Mixte de Recherche, Institut National de la Santé et de la Recherche Médicale U449/Institut National de la Recherche Agronomique 1235 (F.Bo., M.L.), Lyon, France; Department of Obstetrics and Gynecology (A.L.), New York University School of Medicine, New York, New York 10016; Department of Pathology (E.L.), Umeå University, SE-901 87 Umeå, Sweden; Institute of Cancer Epidemiology (A.Tj., A.O.), Danish Cancer Society, DK-2100 Copenhagen, Denmark; Department of Clinical Epidemiology (K.O.), Aarhus University Hospital, DK-8000 C Aalborg, Denmark; Institut National de la Santé et de la Recherche Médicale (F.C.-C., S.M., V.J.), Institut Gustave Roussy, 94805 Villejuif, France; German Cancer Research Center (R.K., J.L., S.Ro.), 69120 Heidelberg, Germany; German Institute of Human Nutrition (T.P., H.B.), Potsdam-Rehbrücke, 14558 Nuthetal, Germany; University of Athens Medical School (D.T., A.Tr., V.B.), Athens 11527, Greece; Department of Molecular and Nutritional Epidemiology (D.P.), CSPO-Scientific Institute of Tuscany, 50135 Florence, Italy; Epidemiology Unit (F.Be.), Istituto Nazionale Tumori, 20133 Milan, Italy; Cancer Registry (R.T.), Azienda Ospedaliera "Civile M.P. Arezzo," 98158 Ragusa, Italy; CPO-Piemonte (C.S.), 10126 Torino, Italy; Dipartimento di Medicina Clinica e Sperimentale (A.M.), Federico II University of Naples, 80131 Naples, Italy; Public Health and Health Planning Directorate (J.R.Q.), Asturias, Spain; Institut d’Investigació Biomèdica de Bellvitge (M.A.M.), Catalan Institute of Oncology, 08907 Barcelona, Spain; Andalusian School of Public Health (M.-J.S.), Granada, Spain; Public Health Department of Gipuzkoa (N.L.), Basque Government; Epidemiology Department (M.J.T.), Health Council of Murcia, 30008 Murcia, Spain; Public Health Institute of Navarra (E.A.), Pamplona, Spain; National Institute of Public Health and the Environment (H.B.B.-d.M.), 3720 BA Bilthoven, The Netherlands; Julius Center for Health Sciences and Primary Care (P.H.M.P., C.H.v.G.), University Medical Center, 3508 CX Utrecht, The Netherlands; Clinical Gerontology (K.-T.K.), Medical Research Council Centre for Nutritional Epidemiology in Cancer Prevention and Survival (S.B.), Department of Public Health and Primary Care, University of Cambridge, Cambridge CB2 1TN, United Kingdom; Medical Research Council Dunn Human Nutrition Unit (S.B.), Cambridge CB2 2XY, United Kingdom; Cancer Research U.K. Epidemiology Unit (N.A., T.K.), University of Oxford, Oxford OX3 7LF, United Kingdom; and Department of Epidemiology and Public Health (E.R.), Imperial College London, London SW7 2AZ, United Kingdom

Address all correspondence and requests for reprints to: Professor Rudolf Kaaks, German National Cancer Center (DKFZ), Division of Cancer Epidemiology, 69120 Heidelberg, Germany. E-mail: r.kaaks{at}dkfz.de.

Background: Adiponectin, an adipocytokine secreted by adipose tissue, is decreased in obesity, insulin resistance, type 2 diabetes, and polycystic ovary syndrome, all of which are well-established risk factors for endometrial cancer.

Methods: We conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition to examine the relation between prediagnostic plasma adiponectin levels and endometrial cancer risk. Among pre- and postmenopausal women who were not currently using exogenous hormones, 284 women developed incident endometrial cancer during an average of 5.1 yr of follow-up. Using risk set sampling, 548 control subjects were selected, matched on center, age, menopausal status, phase of menstrual cycle, time of blood draw, and fasting status. Conditional logistic regression models were used to estimate relative risks and 95% confidence intervals.

Results: Adiponectin levels were inversely associated with endometrial cancer risk [body mass index-adjusted relative risk for the top vs. bottom quartile = 0.56 (95% confidence interval 0.36–0.86), Ptrend = 0.006]. There was evidence of a stronger inverse association among obese women than among nonobese women (Pheterogeneity = 0.03). The inverse association also appeared stronger for women who were postmenopausal or perimenopausal than premenopausal at baseline, but this was not statistically significantly heterogeneous (Pheterogeneity = 0.51). The association remained statistically significant after separate adjustment for other obesity-related physiological risk factors such as C-peptide, IGF binding protein-1, IGF binding protein-2, SHBG, estrone, or free testosterone but only marginally statistically significant after simultaneous adjustment for these factors.

Conclusions: High circulating adiponectin levels are associated with reduced endometrial cancer risk, largely independent of other obesity-related risk factors.




This article has been cited by other articles:


Home page
 Am. J. Clin. Nutr.Home page
F. Ziemke and C. S Mantzoros
Adiponectin in insulin resistance: lessons from translational research
Am. J. Clinical Nutrition, January 1, 2010; 91(1): 258S - 261S.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
R. Z. Stolzenberg-Solomon, S. Weinstein, M. Pollak, Y. Tao, P. R. Taylor, J. Virtamo, and D. Albanes
Prediagnostic Adiponectin Concentrations and Pancreatic Cancer Risk in Male Smokers
Am. J. Epidemiol., November 1, 2008; 168(9): 1047 - 1055.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
N. E Allen, T. J Key, L. Dossus, S. Rinaldi, A. Cust, A. Lukanova, P. H Peeters, N C. Onland-Moret, P. H Lahmann, F. Berrino, et al.
Endogenous sex hormones and endometrial cancer risk in women in the European Prospective Investigation into Cancer and Nutrition (EPIC)
Endocr. Relat. Cancer, June 1, 2008; 15(2): 485 - 497.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
M. J. Gunter, D. R. Hoover, H. Yu, S. Wassertheil-Smoller, J. E. Manson, J. Li, T. G. Harris, T. E. Rohan, X. Xue, G. Y.F. Ho, et al.
A Prospective Evaluation of Insulin and Insulin-like Growth Factor-I as Risk Factors for Endometrial Cancer
Cancer Epidemiol. Biomarkers Prev., April 1, 2008; 17(4): 921 - 929.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
M. L. McCullough, A. V. Patel, R. Patel, C. Rodriguez, H. S. Feigelson, E. V. Bandera, T. Gansler, M. J. Thun, and E. E. Calle
Body Mass and Endometrial Cancer Risk by Hormone Replacement Therapy and Cancer Subtype
Cancer Epidemiol. Biomarkers Prev., January 1, 2008; 17(1): 73 - 79.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
A. E. Cust, N. Slimani, R. Kaaks, M. van Bakel, C. Biessy, P. Ferrari, M. Laville, A. Tjonneland, A. Olsen, K. Overvad, et al.
Dietary Carbohydrates, Glycemic Index, Glycemic Load, and Endometrial Cancer Risk within the European Prospective Investigation into Cancer and Nutrition Cohort
Am. J. Epidemiol., October 15, 2007; 166(8): 912 - 923.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
L. Cong, J. Gasser, J. Zhao, B. Yang, F. Li, and A. Z Zhao
Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells, HEC-1-A and RL95 2
Endocr. Relat. Cancer, September 1, 2007; 14(3): 713 - 720.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
A. E Cust, R. Kaaks, C. Friedenreich, F. Bonnet, M. Laville, A. Tjonneland, A. Olsen, K. Overvad, M. U. Jakobsen, V. Chajes, et al.
Metabolic syndrome, plasma lipid, lipoprotein and glucose levels, and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
Endocr. Relat. Cancer, September 1, 2007; 14(3): 755 - 767.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
D. Barb, C. J Williams, A. K Neuwirth, and C. S Mantzoros
Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence
Am. J. Clinical Nutrition, September 1, 2007; 86(3): 858S - 866S.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2007 by The Endocrine Society