| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Twin Research and Genetic Epidemiology Unit (A.V., T.D.S.) and Department of Chemical Pathology (R.S.), St. Thomas’ Hospital, London SE1 7EH, United Kingdom; and Department of Pediatrics (A.A., J.P.G., M.K.), Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103
Address all correspondence and requests for reprints to: Abraham Aviv, M.D., Room F-464 MSB, Department of Pediatrics, Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, New Jersey 07103. E-mail: avivab{at}umdnj.edu.
Context: Leukocyte telomere length is inversely correlated with age, insulin resistance, serum leptin, and smoking.
Objective: We explored whether menopausal status modifies the relations between leukocyte telomere length and insulin resistance. In addition, we examined the effect of menopause on the relation between leukocyte telomere length and C-reactive protein (CRP), an index of inflammation.
Design: This was an observational cohort study.
Setting: The study setting was community based.
Participants: A total of 1517 women aged 18–79 yr selected only for belonging to a twin pair and representative of the general population participated in the study.
Main Outcome Measure: Leukocyte telomere restriction fragment length (TRFL) was measured.
Results: Insulin resistance (expressed in the homeostasis model assessment), leptin, and CRP were inversely correlated with leukocyte TRFL in premenopausal but not postmenopausal women. Insulin resistance, CRP, but not leptin independently accounted for variation in white blood cell TRFL in premenopausal women.
Conclusions: Menopausal status impacts leukocyte telomere length and its relation with insulin resistance and inflammation in women.
This article has been cited by other articles:
 |
|
 |
|
  W. R. Wilson, K. E. Herbert, Y. Mistry, S. E. Stevens, H. R. Patel, R. A. Hastings, M. M. Thompson, and B. Williams Blood leucocyte telomere DNA content predicts vascular telomere DNA content in humans with and without vascular disease Eur. Heart J., September 1, 2008; (2008) ehn386v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. O'Donnell, S. Demissie, M. Kimura, D. Levy, J. P. Gardner, C. White, R. B. D'Agostino, P. A. Wolf, J. Polak, L. A. Cupples, et al. Leukocyte Telomere Length and Carotid Artery Intimal Medial Thickness: The Framingham Heart Study Arterioscler. Thromb. Vasc. Biol., June 1, 2008; 28(6): 1165 - 1171. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kimura, J. v. B. Hjelmborg, J. P. Gardner, L. Bathum, M. Brimacombe, X. Lu, L. Christiansen, J. W. Vaupel, A. Aviv, and K. Christensen Telomere Length and Mortality: A Study of Leukocytes in Elderly Danish Twins Am. J. Epidemiol., April 1, 2008; 167(7): 799 - 806. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Vasan, S. Demissie, M. Kimura, L. A. Cupples, N. Rifai, C. White, T. J. Wang, J. P. Gardner, X. Cao, E. J. Benjamin, et al. Association of Leukocyte Telomere Length With Circulating Biomarkers of the Renin-Angiotensin-Aldosterone System: The Framingham Heart Study Circulation, March 4, 2008; 117(9): 1138 - 1144. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. F. Cherkas, J. L. Hunkin, B. S. Kato, J. B. Richards, J. P. Gardner, G. L. Surdulescu, M. Kimura, X. Lu, T. D. Spector, and A. Aviv The Association Between Physical Activity in Leisure Time and Leukocyte Telomere Length Arch Intern Med, January 28, 2008; 168(2): 154 - 158. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. De Meyer, E. R. Rietzschel, M. L. De Buyzere, D. De Bacquer, W. Van Criekinge, G. G. De Backer, T. C. Gillebert, P. Van Oostveldt, S. Bekaert, and on behalf of the Asklepios investigators Paternal age at birth is an important determinant of offspring telomere length Hum. Mol. Genet., December 15, 2007; 16(24): 3097 - 3102. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J B. Richards, A. M Valdes, J. P Gardner, D. Paximadas, M. Kimura, A. Nessa, X. Lu, G. L Surdulescu, R. Swaminathan, T. D Spector, et al. Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women Am. J. Clinical Nutrition, November 1, 2007; 86(5): 1420 - 1425. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Shen, M. B. Terry, I. Gurvich, Y. Liao, R. T. Senie, and R. M. Santella Short Telomere Length and Breast Cancer Risk: A Study in Sister Sets Cancer Res., June 1, 2007; 67(11): 5538 - 5544. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. McGrath, J. Y.Y. Wong, D. Michaud, D. J. Hunter, and I. De Vivo Telomere Length, Cigarette Smoking, and Bladder Cancer Risk in Men and Women Cancer Epidemiol. Biomarkers Prev., April 1, 2007; 16(4): 815 - 819. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Gardner, M. Kimura, W. Chai, J. F. Durrani, L. Tchakmakjian, X. Cao, X. Lu, G. Li, A. P. Peppas, J. Skurnick, et al. Telomere Dynamics in Macaques and Humans J. Gerontol. A Biol. Sci. Med. Sci., April 1, 2007; 62(4): 367 - 374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Fitzpatrick, R. A. Kronmal, J. P. Gardner, B. M. Psaty, N. S. Jenny, R. P. Tracy, J. Walston, M. Kimura, and A. Aviv Leukocyte Telomere Length and Cardiovascular Disease in the Cardiovascular Health Study Am. J. Epidemiol., January 1, 2007; 165(1): 14 - 21. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Aviv, A. M Valdes, and T. D Spector Human telomere biology: pitfalls of moving from the laboratory to epidemiology Int. J. Epidemiol., December 1, 2006; 35(6): 1424 - 1429. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
