| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Departments of Medicine, Radiology, and Epidemiology and Biostatistics, Endocrine, Nuclear Medicine, and Biostatistics Services, Memorial Hospital for Cancer and Allied Diseases, Memorial Sloan-Kettering Cancer Center, New York, New York 10021
Address all correspondence and requests for reprints to: Richard J. Robbins, M.D., Chairman, Department of Medicine, The Methodist Hospital, 6565 Fannin Street, Houston, Texas 77030. E-mail: rjrobbins{at}tmh.tmc.edu.
Context/Objective: Approximately 15% of thyroid cancer patients develop subsequent metastases. The clinical course of patients with metastatic thyroid carcinoma is highly variable. We hypothesized that the metabolic activity of metastatic lesions, as defined by retention of 2-[18F]fluoro-2-deoxyglucose (FDG), would correlate with prognosis.
Design/Patients: The initial FDG-positron emission tomography (PET) scans from 400 thyroid cancer patients were retrospectively reviewed and compared with overall survival (median follow-up, 7.9 yr). We examined the prognostic value of clinical information such as gender, age, serum thyroglobulin, American Joint Committee on Cancer (AJCC) stage, histology, radioiodine avidity, FDG-PET positivity, number of FDG-avid lesions, and the glycolytic rate of the most active lesion.
Results: Age, initial stage, histology, thyroglobulin, radioiodine uptake, and PET outcomes all correlated with survival by univariate analysis. However, only age and PET results continued to be strong predictors of survival under multivariate analysis. The initial American Joint Committee on Cancer stage was not a significant predictor of survival by multivariate analysis. There were significant inverse relationships between survival and both the glycolytic rate of the most active lesion and the number of FDG-avid lesions.
Conclusions: FDG-PET scanning is a simple, expensive, but powerful means to restage thyroid cancer patients who develop subsequent metastases, assigning them to groups that are either at low (FDG negative) or high (FDG positive) risk of cancer-associated mortality. We propose that the aggressiveness of therapy for metastases should match the FDG-PET status.
This article has been cited by other articles:
 |
|
 |
|
  D. A. Mankoff and F. Dehdashti Imaging Tumor Phenotype: 1 Plus 1 Is More Than 2 J. Nucl. Med., October 1, 2009; 50(10): 1567 - 1569. [Full Text] [PDF]
|
|
|
|
|
|
O. Prante, S. Maschauer, V. Fremont, J. Reinfelder, R. Stoehr, M. Szkudlinski, B. Weintraub, A. Hartmann, and T. Kuwert Regulation of Uptake of 18F-FDG by a Follicular Human Thyroid Cancer Cell Line with Mutation-Activated K-Ras J. Nucl. Med., August 1, 2009; 50(8): 1364 - 1370. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Taieb, F. Sebag, A. Barlier, L. Tessonnier, F. F. Palazzo, I. Morange, P. Niccoli-Sire, N. Fakhry, C. De Micco, S. Cammilleri, et al. 18F-FDG Avidity of Pheochromocytomas and Paragangliomas: A New Molecular Imaging Signature? J. Nucl. Med., May 1, 2009; 50(5): 711 - 717. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P.S. Dunphy and J. S. Lewis Radiopharmaceuticals in Preclinical and Clinical Development for Monitoring of Therapy with PET J. Nucl. Med., May 1, 2009; 50(Suppl_1): 106S - 121S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Leboulleux, P. R. Schroeder, N. L. Busaidy, A. Auperin, C. Corone, H. A. Jacene, M. E. Ewertz, C. Bournaud, R. L. Wahl, S. I. Sherman, et al. Assessment of the Incremental Value of Recombinant Thyrotropin Stimulation before 2-[18F]-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography/Computed Tomography Imaging to Localize Residual Differentiated Thyroid Cancer J. Clin. Endocrinol. Metab., April 1, 2009; 94(4): 1310 - 1316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Woyach, R. T. Kloos, M. D. Ringel, D. Arbogast, M. Collamore, J. A. Zwiebel, M. Grever, M. Villalona-Calero, and M. H. Shah Lack of Therapeutic Effect of the Histone Deacetylase Inhibitor Vorinostat in Patients with Metastatic Radioiodine-Refractory Thyroid Carcinoma J. Clin. Endocrinol. Metab., January 1, 2009; 94(1): 164 - 170. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Gupta-Abramson, A. B. Troxel, A. Nellore, K. Puttaswamy, M. Redlinger, K. Ransone, S. J. Mandel, K. T. Flaherty, L. A. Loevner, P. J. O'Dwyer, et al. Phase II Trial of Sorafenib in Advanced Thyroid Cancer J. Clin. Oncol., October 10, 2008; 26(29): 4714 - 4719. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Pfister and J. A. Fagin Refractory Thyroid Cancer: A Paradigm Shift in Treatment Is Not Far Off J. Clin. Oncol., October 10, 2008; 26(29): 4701 - 4704. [Full Text] [PDF]
|
|
|
|
 |
|
 C. Romei, R. Ciampi, P. Faviana, L. Agate, E. Molinaro, V. Bottici, F. Basolo, P. Miccoli, F. Pacini, A. Pinchera, et al. BRAFV600E mutation, but not RET/PTC rearrangements, is correlated with a lower expression of both thyroperoxidase and sodium iodide symporter genes in papillary thyroid cancer Endocr. Relat. Cancer, June 1, 2008; 15(2): 511 - 520. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S Al-Zahrani, M.-E. M Abouzied, S. A. Salam, G. Mohamed, A. Rifai, A. Al Sugair, and T. Amin The role of F-18-fluorodeoxyglucose positron emission tomography in the postoperative evaluation of differentiated thyroid cancer Eur. J. Endocrinol., May 1, 2008; 158(5): 683 - 689. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. T. Kloos Approach to the Patient with a Positive Serum Thyroglobulin and a Negative Radioiodine Scan after Initial Therapy for Differentiated Thyroid Cancer J. Clin. Endocrinol. Metab., May 1, 2008; 93(5): 1519 - 1525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M M Muresan, P Olivier, J Leclere, F Sirveaux, L Brunaud, M Klein, R Zarnegar, and G Weryha Bone metastases from differentiated thyroid carcinoma Endocr. Relat. Cancer, March 1, 2008; 15(1): 37 - 49. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Laure Giraudet, A. Al Ghulzan, A. Auperin, S. Leboulleux, A. Chehboun, F. Troalen, C. Dromain, J. Lumbroso, E. Baudin, and M. Schlumberger Progression of medullary thyroid carcinoma: assessment with calcitonin and carcinoembryonic antigen doubling times Eur. J. Endocrinol., February 1, 2008; 158(2): 239 - 246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Giraudet, D. Vanel, S. Leboulleux, A. Auperin, C. Dromain, L. Chami, N. Ny Tovo, J. Lumbroso, N. Lassau, G. Bonniaud, et al. Imaging Medullary Thyroid Carcinoma with Persistent Elevated Calcitonin Levels J. Clin. Endocrinol. Metab., November 1, 2007; 92(11): 4185 - 4190. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Mankoff, J. F. Eary, J. M. Link, M. Muzi, J. G. Rajendran, A. M. Spence, and K. A. Krohn Tumor-Specific Positron Emission Tomography Imaging in Patients: [18F] Fluorodeoxyglucose and Beyond Clin. Cancer Res., June 15, 2007; 13(12): 3460 - 3469. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P T Finger, K Chin, and C E Iacob 18-Fluorine-labelled 2-deoxy-2-fluoro-D-glucose positron emission tomography/computed tomography standardised uptake values: a non-invasive biomarker for the risk of metastasis from choroidal melanoma Br J Ophthalmol, October 1, 2006; 90(10): 1263 - 1266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Pryma, H. Schoder, M. Gonen, R. J. Robbins, S. M. Larson, and H. W.D. Yeung Diagnostic Accuracy and Prognostic Value of 18F-FDG PET in Hurthle Cell Thyroid Cancer Patients J. Nucl. Med., August 1, 2006; 47(8): 1260 - 1266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Durante, N. Haddy, E. Baudin, S. Leboulleux, D. Hartl, J. P. Travagli, B. Caillou, M. Ricard, J. D. Lumbroso, F. De Vathaire, et al. Long-Term Outcome of 444 Patients with Distant Metastases from Papillary and Follicular Thyroid Carcinoma: Benefits and Limits of Radioiodine Therapy J. Clin. Endocrinol. Metab., August 1, 2006; 91(8): 2892 - 2899. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Pacini, M. Schlumberger, H. Dralle, R. Elisei, J. W A Smit, W. Wiersinga, and the European Thyroid Cancer Taskforce European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium. Eur. J. Endocrinol., June 1, 2006; 154(6): 787 - 803. [Full Text] [PDF]
|
|
|
|
|
|
S. M. Larson and L. H. Schwartz 18F-FDG PET as a Candidate for "Qualified Biomarker": Functional Assessment of Treatment Response in Oncology J. Nucl. Med., June 1, 2006; 47(6): 901 - 903. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
