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Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2006-0049
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The Journal of Clinical Endocrinology & Metabolism Vol. 91, No. 12 5008-5012
Copyright © 2006 by The Endocrine Society

CYP11B2 –344T/C Gene Polymorphism and Blood Pressure in Patients with Acromegaly

Paolo Mulatero, Franco Veglio, Pietro Maffei, Marta Bondanelli, Silvia Bovio, Fulvia Daffara, Giannina Leotta, Alberto Angeli, Chiara Calvo, Chiara Martini, Ettore C. degli Uberti and Massimo Terzolo

Division of Internal Medicine and Hypertension (P.Mu., F.V., G.L., C.C.), San Vito Hospital, and Medicina Interna I (S.B., F.D., A.A., M.T.), Dipartimento di Scienze Cliniche e Biologiche, S. Luigi Hospital, Orbassano, University of Torino, 10133 Torino, Italy; Clinica Medica III (P.Ma., C.M.), Dipartimento di Scienze Mediche e Chirurgiche, University of Padua, 35100 Padua, Italy; and Department of Biomedical Sciences and Advanced Therapies (M.B., E.C.d.U.), Section of Endocrinology, University of Ferrara, 44100 Ferrara, Italy

Address all correspondence and requests for reprints to: Paolo Mulatero, Hypertension Unit, Ospedale San Vito, Strada San Vito 34, 10133 Torino, Italy. E-mail: paolo.mulatero{at}libero.it.

Context: The pathogenesis of increased blood pressure (BP) in acromegaly is unclear, and the role of IGF-I levels and the renin-angiotensin-aldosterone system (RAAS) in this disease remains controversial.

Objective and Design: The aim of this study was to investigate the role of gene polymorphisms of the RAAS and involved in sodium handling on BP in acromegaly.

Setting and Patients: We conducted a multicentric retrospective study that included 100 consecutive patients with acromegaly referred during the period 2000–2003.

Intervention: All patients were genotyped for ACE I/D, AGT M235T, CYP11B2 –344T/C, B2R –58T/C, and {alpha}-adducin G460W polymorphisms.

Main Outcome Measure: We assessed the prevalence of hypertension and BP according to the genotype.

Results: Patients with the CYP11B2 –344CC genotype displayed a significant increase in the risk of hypertension compared with patients with CT/TT genotypes (odds ratio = 4.0; 95% confidence interval = 1.4–11.6; P = 0.01). Consistently, a significant proportion of patients with the CYP11B2 –344CC genotypes were under antihypertensive treatment (73.1%) compared with patients with the TT/TC genotypes (38.2%; P = 0.003). Patients with the –344CC genotype displayed a significant increase in systolic BP (10.2 ± 4.3 mm Hg; P = 0.02) but not a significant increase in diastolic BP (2.6 ± 2.6 mm Hg; P = 0.32) compared with patients with the CT/TT genotype.

Conclusions: We have shown an association of the –344T/C CYP11B2 gene polymorphism with BP in patients affected by acromegaly. These findings suggest that the RAAS is implicated in the pathogenesis of hypertension in acromegaly.







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Copyright © 2006 by The Endocrine Society