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Exercise Training Lowers Plasma Visfatin Concentrations in Patients with Type 1 Diabetes

Departments of Clinical Pharmacology (D.G.H., J.P., M.M., M.W.), Physical Medicine and Rehabilitation (G.F.W.), and Department of Internal Medicine III, Division of Endocrinology and Metabolism (M.W.), Medical University of Vienna, 1090 Vienna, Austria; and Rehabilitationszentrum für Diabetes der PVA (M.F.), 2534 Alland, Austria

Address all correspondence and requests for reprints to: Dr. Michael Wolzt, Medical University of Vienna, Department of Clinical Pharmacology, Allgemeines Krankenhaus Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria. E-mail: michael.wolzt{at}meduniwien.ac.at.

Context: Exercise training exerts beneficial effects on metabolic and vascular risk factors in patients with type 1 diabetes mellitus (T1DM). It is unknown whether training also influences concentrations of visfatin, a novel insulin-mimetic adipocytokine.

Objectives: In this study, we have investigated whether plasma visfatin concentrations are altered by training in patients with T1DM.

Design and Patients: Fasting plasma visfatin concentrations and metabolic parameters were measured in 18 patients with T1DM who participated in a supervised aerobic exercise program for 4 months. Three subjects discontinued training prematurely after 2 months. Samples were obtained before and during training and 8 months after the end of regular exercise. Fourteen healthy young subjects served as controls.

Results: At baseline, patients with T1DM had higher visfatin concentrations than controls (64.1 ± 12.0 vs. 1.3 ± 0.0 ng/ml, P < 0.01). Exercise reduced visfatin after 2 and 4 months to 27.8 ± 2.6 (n = 18) and 17.5 ± 3.4 ng/ml (n = 15), respectively (P < 0.001 for n = 15 subjects who participated in all visits, ANOVA). This effect was maintained 8 months after cessation of training, with visfatin concentrations of 19.7 ± 5.0 ng/ml (n = 15). Metabolic parameters were not affected by the training program.

Conclusion: Elevated visfatin concentrations in patients with T1DM can be lowered by regular physical exercise. It is unknown whether glucose tolerance is affected by changes in visfatin concentrations.

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