This Article Full Text Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Goswami, R. Articles by Singh, S. Search for Related Content PubMed PubMed Citation Articles by Goswami, R. Articles by Singh, S. Related Collections Pediatric Endocrinology Thyroid Autoimmunity Calcium and Bone Metabolism Diabetes and Insulin Female Endocrinology

Prevalence of Thyroid Autoimmunity in Sporadic Idiopathic Hypoparathyroidism in Comparison to Type 1 Diabetes and Premature Ovarian Failure

Department of Endocrinology and Metabolism (R.G., N.G., D.R., N.T.), All India Institute of Medical Sciences, New Delhi 110029, India; Institute of Nuclear Medicine and Allied Sciences (R.K.M., S.S.), New Delhi 110054, India; and Department of Obstetrics and Gynecology (D.G.), Maulana Azad Medical College, New Delhi 110002, India

Address all correspondence and requests for reprints to: Dr. Ravinder Goswami, M.D., D.M., Associate Professor, Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi 110029, India. E-mail: gosravinder{at}hotmail.com.

Context: Thyroid autoimmunity is the most common coexistent endocrinopathy in type 1 diabetes (T1D), Addison’s disease, and premature ovarian failure (POF). Although the role of autoimmunity is being investigated in patients with sporadic idiopathic hypoparathyroidism (SIH), there is little information on coexistent thyroid autoimmunity.

Objective: Our objective was to assess the prevalence of thyroid peroxidase autoantibodies (TPOAb) and thyroid dysfunction in patients with SIH and its comparison with that in T1D, POF, and Hashimoto’s thyroiditis (HT) and age- and sex-matched healthy controls (for SIH).

Design and Setting: We conducted a case control study in a tertiary care setting.

Patients and Methods: Subjects were consecutive patients with SIH (n = 87), T1D (n = 100), POF (n = 58), and HT (n = 47) and healthy controls (100 females and 64 males). Serum free T₃, free T₄, TSH, and TPOAb (normal 34 IU/ml) were measured by electrochemiluminescence assay. Subjects with 1) serum TSH at least 5 µU/ml along with TPOAb more than 34 IU/ml; 2) TSH at least 10 µU/ml but normal TPOAb titers; or 3) Graves’ disease were considered to have thyroid dysfunction.

Results: TPOAb positivity (>34 IU/ml) in females was 14.6% in SIH, 24.1% in POF, and 42.1% in T1D compared with 76.6% in HT and 9% in healthy controls. The frequencies of TPOAb positivity and thyroid dysfunction in patients with SIH were comparable to those in control and POF groups, but significantly less than in T1D and HT groups.

Conclusion: The frequencies of TPOAb and thyroid dysfunction were not significantly higher in patients with SIH than in healthy controls, unlike in patients with T1D and POF.

This article has been cited by other articles:

				N. Gleicher, A. Weghofer, K. Oktay, and D. Barad Do etiologies of premature ovarian aging (POA) mimic those of premature ovarian failure (POF)? Hum. Reprod., October 1, 2009; 24(10): 2395 - 2400. [Abstract] [Full Text] [PDF]