| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Department of Obstetrics and Gynecology (R.R.G., K.G., B.S., L.K.) and Institute for Reproductive Medicine (J.G., E.N., M.S.), Münster University Hospital, D-48149 Münster, Germany
Address all correspondence and requests for reprints to: Prof. Dr. Manuela Simoni, Institute for Reproductive Medicine, Münster University Hospital, Domagkstrasse 11, D-48149 Muenster, Germany. E-mail: manuela.simoni{at}ukmuenster.de.
Context: FSH is essential for follicular maturation. Data from ovarian hyperstimulation cycles suggest that FSH action is attenuated by a frequent single nucleotide polymorphism of the FSH receptor gene exchanging Asn for Ser at codon 680.
Objective: We hypothesized that the FSH receptor genotype influences menstrual cycle dynamics.
Design: Menstrual cycle was monitored from the midluteal phase through ovulation until the consecutive menstruation.
Setting: The study was conducted at the University research center.
Subjects: Women homozygous for the Asn680 (n = 12) and Ser680 (n = 9) variants with normal menstrual cycles volunteered for the study.
Interventions: There were no interventions.
Main Outcome Measurements: Follicular growth, serum LH, FSH, estradiol, progesterone, inhibin A, inhibin B and antimullerian hormone were measured.
Results: During the luteo-follicular transition, serum levels of estradiol, progesterone, and inhibin A were significantly lower, and FSH started to rise earlier in the Ser680/Ser680 group. FSH levels were steadily and significantly higher, and the mean area under the FSH curve was 31% greater in this group (P < 0.002). No differences were observed in estradiol, inhibin B, and growth velocities of dominant follicles. The time from luteolysis to ovulation was significantly longer in women with the Ser680/Ser680 (13.6 ± 1.01 d) compared with Asn680/Asn680 (11.3 ± 0.61 d, P < 0.05) genotype with a significant difference in total menstrual cycle length (29.3 vs. 27.0 d, respectively; P < 0.05).
Conclusions: The FSH receptor Ser680/Ser680 genotype is associated with higher ovarian threshold to FSH, decreased negative feedback of luteal secretion to the pituitary during the intercycle transition, and longer menstrual cycles.
This article has been cited by other articles:
 |
|
 |
|
  M. Simoni, C.B. Tempfer, B. Destenaves, and B.C.J.M. Fauser Functional genetic polymorphisms and female reproductive disorders: Part I: polycystic ovary syndrome and ovarian response Hum. Reprod. Update, September 1, 2008; 14(5): 459 - 484. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Binder, R. Dittrich, I. Hager, A. Muller, S. Oeser, M. W Beckmann, M. Hamori, P. A Fasching, and R. Strick Association of FSH receptor and CYP19A1 gene variations with sterility and ovarian hyperstimulation syndrome Reproduction, January 1, 2008; 135(1): 107 - 116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.C.J.M. Fauser, K. Diedrich, P. Devroey, and on behalf of the Evian Annual Reproduction (EVAR) Predictors of ovarian response: progress towards individualized treatment in ovulation induction and ovarian stimulation Hum. Reprod. Update, January 1, 2008; 14(1): 1 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Cushman, M. F. Allan, R. M. Thallman, and L. V. Cundiff Characterization of biological types of cattle (Cycle VII): Influence of postpartum interval and estrous cycle length on fertility J Anim Sci, September 1, 2007; 85(9): 2156 - 2162. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-H. Choi, A. S. T. Wong, H.-F. Huang, and P. C. K. Leung Gonadotropins and Ovarian Cancer Endocr. Rev., June 1, 2007; 28(4): 440 - 461. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. L. Ryan, X. Feng, C. B. d'Alva, M. Zhang, B. J. Van Voorhis, E. M. Pinto, A. E. F. Kubias, S. R. Antonini, A. C. Latronico, and D. L. Segaloff Evaluating the Roles of Follicle-Stimulating Hormone Receptor Polymorphisms in Gonadal Hyperstimulation Associated with Severe Juvenile Primary Hypothyroidism J. Clin. Endocrinol. Metab., June 1, 2007; 92(6): 2312 - 2317. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Kevenaar, A. P.N. Themmen, J. S.E. Laven, B. Sonntag, S. L. Fong, A. G. Uitterlinden, F. H. de Jong, H. A.P. Pols, M. Simoni, and J. A. Visser Anti-Mullerian hormone and anti-Mullerian hormone type II receptor polymorphisms are associated with follicular phase estradiol levels in normo-ovulatory women Hum. Reprod., June 1, 2007; 22(6): 1547 - 1554. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Kara, P. Crepieux, C. Gauthier, N. Martinat, V. Piketty, F. Guillou, and E. Reiter A Phosphorylation Cluster of Five Serine and Threonine Residues in the C-Terminus of the Follicle-Stimulating Hormone Receptor Is Important for Desensitization But Not for {beta}-Arrestin-Mediated ERK Activation Mol. Endocrinol., November 1, 2006; 20(11): 3014 - 3026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F.J. Broekmans, J. Kwee, D.J. Hendriks, B.W. Mol, and C.B. Lambalk A systematic review of tests predicting ovarian reserve and IVF outcome Hum. Reprod. Update, November 1, 2006; 12(6): 685 - 718. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.Q. Yang, K.Y.K. Chan, H.Y.S. Ngan, U.S. Khoo, P.M. Chiu, Q.K.Y. Chan, W.C. Xue, and A.N.Y. Cheung Single nucleotide polymorphisms of follicle-stimulating hormone receptor are associated with ovarian cancer susceptibility Carcinogenesis, July 1, 2006; 27(7): 1502 - 1506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Axmon, L. Rylander, M. Albin, and L. Hagmar Factors affecting time to pregnancy Hum. Reprod., May 1, 2006; 21(5): 1279 - 1284. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
