| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Division of Endocrinology, Metabolism, and Molecular Medicine (S.S., A.D.), Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611; Department of Obstetrics and Gynecology (R.S.L.), Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033; and Division of Endocrinology, Diabetes, and Hypertension (R.B.-L.), Brigham and Women’s Hospital, Boston, Massachusetts 02115
Address all correspondence and requests for reprints to: Andrea Dunaif, M.D., Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Tarry Building 15-709, Chicago, Illinois 60611-3008. E-mail: a-dunaif{at}northwestern.edu.
Context: Dyslipidemia is a feature of polycystic ovary syndrome (PCOS), but its pathogenesis remains controversial.
Objective: The objective of this study was to test the hypothesis that dyslipidemia is a heritable trait in sisters of women with PCOS.
Design: A case-control design was used.
Setting: The study took place at General Clinical Research Centers in four academic medical centers in the United States.
Patients: The subjects included 385 sisters of women with PCOS with the following reproductive phenotypes: sisters with PCOS (n = 51), sisters with hyperandrogenemia and regular menses (HA) (n = 38), unaffected sisters (n = 143), and unknown phenotypes (n = 153). One hundred twenty-five control women of comparable age, body mass index, and ethnicity to women with PCOS were included.
Interventions: Fasting blood was obtained for measurements of lipid profile, reproductive hormones, glucose, and insulin levels.
Main Outcome Measures: The main outcome measures included lipid and lipoprotein levels and prevalence of metabolic syndrome.
Results: Sisters with PCOS and HA phenotypes had higher total (P 
0.001) and low-density lipoprotein cholesterol levels (P 0.01) compared with unaffected sisters and control women. Triglyceride levels were elevated only in sisters with the PCOS phenotype (P < 0.05). The prevalence of metabolic syndrome was increased in sisters with the PCOS (n = 29) and HA (n = 17) phenotypes compared with unaffected sisters (n = 85) (P < 0.001 and P < 0.05, respectively).
Conclusions: Low-density lipoprotein levels are increased in affected sisters of women with PCOS consistent with a heritable trait. The prevalence of metabolic syndrome is increased in affected sisters.
This article has been cited by other articles:
 |
|
 |
|
  A. Biyasheva, R. S. Legro, A. Dunaif, and M. Urbanek Evidence for Association between Polycystic Ovary Syndrome (PCOS) and TCF7L2 and Glucose Intolerance in Women with PCOS and TCF7L2 J. Clin. Endocrinol. Metab., July 1, 2009; 94(7): 2617 - 2625. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Urbanek, G. Nampiaparampil, J. D'Souza, E. Sefton, C. Ackerman, R. S. Legro, and A. Dunaif The Role of Genetic Variation in the Lamin A/C Gene in the Etiology of Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., July 1, 2009; 94(7): 2665 - 2669. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sam, A. D. Coviello, Y.-A. Sung, R. S. Legro, and A. Dunaif Metabolic Phenotype in the Brothers of Women with Polycystic Ovary Syndrome Diabetes Care, June 1, 2008; 31(6): 1237 - 1241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Kent, C. L. Gnatuk, A. R. Kunselman, L. M. Demers, P. A. Lee, and R. S. Legro Hyperandrogenism and Hyperinsulinism in Children of Women with Polycystic Ovary Syndrome: A Controlled Study J. Clin. Endocrinol. Metab., May 1, 2008; 93(5): 1662 - 1669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sir-Petermann, M. Maliqueo, E. Codner, B. Echiburu, N. Crisosto, V. Perez, F. Perez-Bravo, and F. Cassorla Early Metabolic Derangements in Daughters of Women with Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., December 1, 2007; 92(12): 4637 - 4642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Urbanek, S. Sam, R. S. Legro, and A. Dunaif Identification of a Polycystic Ovary Syndrome Susceptibility Variant in Fibrillin-3 and Association with a Metabolic Phenotype J. Clin. Endocrinol. Metab., November 1, 2007; 92(11): 4191 - 4198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. K. Welt, J. A. Gudmundsson, G. Arason, J. Adams, H. Palsdottir, G. Gudlaugsdottir, G. Ingadottir, and W. F. Crowley Characterizing Discrete Subsets of Polycystic Ovary Syndrome as Defined by the Rotterdam Criteria: The Impact of Weight on Phenotype and Metabolic Features J. Clin. Endocrinol. Metab., December 1, 2006; 91(12): 4842 - 4848. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.K. Blank, C.R. McCartney, and J.C. Marshall The origins and sequelae of abnormal neuroendocrine function in polycystic ovary syndrome Hum. Reprod. Update, July 1, 2006; 12(4): 351 - 361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. I. Leibel, E. E. Baumann, M. Kocherginsky, and R. L. Rosenfield Relationship of Adolescent Polycystic Ovary Syndrome to Parental Metabolic Syndrome J. Clin. Endocrinol. Metab., April 1, 2006; 91(4): 1275 - 1283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Coviello, R. S. Legro, and A. Dunaif Adolescent Girls with Polycystic Ovary Syndrome Have an Increased Risk of the Metabolic Syndrome Associated with Increasing Androgen Levels Independent of Obesity and Insulin Resistance J. Clin. Endocrinol. Metab., February 1, 2006; 91(2): 492 - 497. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Barutcuoglu, A. E. Bozdemir, D. Dereli, Z. Parildar, M. I. Mutaf, D. Ozmen, and O. Bayindir Increased Serum Neopterin Levels in Women with Polycystic Ovary Syndrome Ann. Clin. Lab. Sci., January 1, 2006; 36(3): 267 - 272. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
