This Article Full Text Full Text (PDF) All Versions of this Article: 90/6/3622    most recent Author Manuscript (PDF) Submit a related Letter to the Editor Purchase Article View Shopping Cart Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Birkenfeld, A. L. Articles by Jordan, J. Search for Related Content PubMed PubMed Citation Articles by Birkenfeld, A. L. Articles by Jordan, J. Related Collections Cardiovascular Endocrinology Metabolism

Lipid Mobilization with Physiological Atrial Natriuretic Peptide Concentrations in Humans

Franz-Volhard Clinical Research Center (A.L.B., M.Bo., F.A., K.H., G.F., F.C.L., J.J.), Charité–Campus Buch and Helios Klinikum, 13125 Berlin, Germany; and Institut National de la Santé et de la Recherche Médicale 586 (C.M., M.Be., M.L.), Institut Louis Bugnard, Université Paul Sabatier, Hôpital Rangueil, 31403 Toulouse Cedex 4, France

Address all correspondence and requests for reprints to: Jens Jordan, M.D., Franz-Volhard Clinical Research Center, Haus 129, Charité Campus Buch, Wiltbergstrasse 50, 13125 Berlin, Germany. E-mail: jordan{at}fvk.charite-buch.de.

Context: Atrial natriuretic peptide (ANP) in pharmacological concentrations stimulates lipid mobilization in humans.

Objective: The objective was to determine the hemodynamic and metabolic response to physiologically relevant ANP concentrations.

Design: The design was a human physiological study, conducted in 2004.

Setting: The study was conducted at an academic research institute.

Participants: Fourteen healthy normal-weight men (30 ± 1.2 yr) participated in the study.

Intervention: Intravenous infusion of human ANP (h-ANP) was administered at rates of 6.25, 12.5, and 25 ng/kg·min.

Main Outcome Measures: We studied local changes in blood flow and glucose and lipid metabolism of abdominal sc adipose tissue and femoral skeletal muscle by microdialysis. Overall changes in energy expenditure and substrate oxidation rates were monitored by indirect calorimetry.

Results: The increase in serum nonesterified fatty acids and glycerol concentrations were correlated with ANP plasma concentrations (r² = 0.86 and r² = 0.76, respectively). In adipose tissue, glycerol increased from 53 ± 6 µmol/liter to 87±13 µmol/liter (P < 0.001). In femoral skeletal muscle, glycerol concentrations did not change, whereas lactate-to-pyruvate ratio decreased from 91 ± 23 to 32 ± 4 (P < 0.001). Indirect calorimetry indicated an increase in lipid oxidation (P < 0.05) concomitantly with a decrease in carbohydrate oxidation (P < 0.01), without changes in overall energy expenditure.

Conclusions: ANP briskly stimulates lipid mobilization and oxidation at plasma concentrations that are encountered in conditions such as heart failure. Natriuretic-peptide induced lipid mobilization might contribute to cardiac cachexia. Drugs that interfere with the natriuretic peptide system should be evaluated for potential metabolic side effects.

This article has been cited by other articles:

				A. L. Birkenfeld, P. Budziarek, M. Boschmann, C. Moro, F. Adams, G. Franke, M. Berlan, M. A. Marques, F. C.G.J. Sweep, F. C. Luft, et al. Atrial Natriuretic Peptide Induces Postprandial Lipid Oxidation in Humans Diabetes, December 1, 2008; 57(12): 3199 - 3204. [Abstract] [Full Text] [PDF]

				C. Moro, F. Pillard, I. de Glisezinski, E. Klimcakova, F. Crampes, C. Thalamas, I. Harant, M.-A. Marques, M. Lafontan, and M. Berlan Exercise-induced lipid mobilization in subcutaneous adipose tissue is mainly related to natriuretic peptides in overweight men Am J Physiol Endocrinol Metab, August 1, 2008; 295(2): E505 - E513. [Abstract] [Full Text] [PDF]

				S. Pilz, H. Scharnagl, B. Tiran, B. Wellnitz, U. Seelhorst, B. O. Boehm, and W. Marz Elevated plasma free fatty acids predict sudden cardiac death: a 6.85-year follow-up of 3315 patients after coronary angiography Eur. Heart J., November 2, 2007; 28(22): 2763 - 2769. [Abstract] [Full Text] [PDF]

				C. Moro, F. Pillard, I. de Glisezinski, F. Crampes, C. Thalamas, I. Harant, M.-A. Marques, M. Lafontan, and M. Berlan Atrial natriuretic peptide contribution to lipid mobilization and utilization during head-down bed rest in humans Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2007; 293(2): R612 - R617. [Abstract] [Full Text] [PDF]

				T. J. Wang, M. G. Larson, M. J. Keyes, D. Levy, E. J. Benjamin, and R. S. Vasan Association of Plasma Natriuretic Peptide Levels With Metabolic Risk Factors in Ambulatory Individuals Circulation, March 20, 2007; 115(11): 1345 - 1353. [Abstract] [Full Text] [PDF]

				A. L. Birkenfeld, M. Boschmann, C. Moro, F. Adams, K. Heusser, J. Tank, A. Diedrich, C. Schroeder, G. Franke, M. Berlan, et al. {beta}-Adrenergic and Atrial Natriuretic Peptide Interactions on Human Cardiovascular and Metabolic Regulation J. Clin. Endocrinol. Metab., December 1, 2006; 91(12): 5069 - 5075. [Abstract] [Full Text] [PDF]

				S. Engeli, M. Boschmann, P. Frings, L. Beck, J. Janke, J. Titze, F. C. Luft, M. Heer, and J. Jordan Influence of Salt Intake on Renin-Angiotensin and Natriuretic Peptide System Genes in Human Adipose Tissue Hypertension, December 1, 2006; 48(6): 1103 - 1108. [Abstract] [Full Text] [PDF]

				S. Pilz, H. Scharnagl, B. Tiran, U. Seelhorst, B. Wellnitz, B. O. Boehm, J. R. Schaefer, and W. Marz Free Fatty Acids Are Independently Associated with All-Cause and Cardiovascular Mortality in Subjects with Coronary Artery Disease J. Clin. Endocrinol. Metab., July 1, 2006; 91(7): 2542 - 2547. [Abstract] [Full Text] [PDF]

				C. Moro, J. Polak, J. Hejnova, E. Klimcakova, F. Crampes, V. Stich, M. Lafontan, and M. Berlan Atrial natriuretic peptide stimulates lipid mobilization during repeated bouts of endurance exercise Am J Physiol Endocrinol Metab, May 1, 2006; 290(5): E864 - E869. [Abstract] [Full Text] [PDF]

				T. Nishikimi, N. Maeda, and H. Matsuoka The role of natriuretic peptides in cardioprotection Cardiovasc Res, February 1, 2006; 69(2): 318 - 328. [Abstract] [Full Text] [PDF]

				M. Lafontan, C. Moro, C. Sengenes, J. Galitzky, F. Crampes, and M. Berlan An Unsuspected Metabolic Role for Atrial Natriuretic Peptides: The Control of Lipolysis, Lipid Mobilization, and Systemic Nonesterified Fatty Acids Levels in Humans Arterioscler. Thromb. Vasc. Biol., October 1, 2005; 25(10): 2032 - 2042. [Abstract] [Full Text] [PDF]