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Estrogen Receptor-Related Receptor : A Mediator of Estrogen Response in Bone

Department of Molecular and Medical Genetics, University of Toronto, Toronto M5S 1A8, Canada

Address all correspondence and requests for reprints to: Dr. Jane E. Aubin, Department of Molecular and Medical Genetics, Faculty of Medicine, University of Toronto, Room 6233, Medical Sciences Building, 1 King’s College Circle, Toronto, Ontario M5S 1A8, Canada. E-mail: jane.aubin{at}utoronto.ca.

Estrogen receptor-related receptor- (ERR) is an orphan nuclear receptor with sequence homology to the estrogen receptors, ER/ß, but it does not bind estrogen. However, several recent studies suggest that ERR not only plays a functional role in osteoblasts but also impinges on the estrogen axis in bone, as it does in at least certain other estrogen target tissues. We summarize here data on ERR and its cellular and molecular modes of action that have broad implications for considering the potential role of this orphan receptor as a new therapeutic target in osteopenic disorders such as osteoporosis as well as other estrogen-responsive conditions.

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