This Article Full Text Full Text (PDF) All Versions of this Article: 90/5/2972    most recent Author Manuscript (PDF) Submit a related Letter to the Editor Purchase Article View Shopping Cart Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Cardona, F. Articles by Tinahones, F. J. Search for Related Content PubMed PubMed Citation Articles by Cardona, F. Articles by Tinahones, F. J. Related Collections Lipid

The Apolipoprotein E Genotype Predicts Postprandial Hypertriglyceridemia in Patients with the Metabolic Syndrome

Servicio de Endocrinología y Nutrición, Hospital Regional Universitario Carlos Haya, 29009 Málaga, Spain

Address all correspondence and requests for reprints to: Dr. F. J. Tinahones, Servicio de Endocrinología y Nutrición, Pabellón 1 Sótano Hospital Civil, Hospital Regional Universitario Carlos Haya, Plaza del Hospital Civil, 29009 Málaga, Spain. E-mail: fjtinahones{at}terra.es; fernando.cardona.exts{at}juntadeandalucia.es.

Apolipoprotein E (apo E) is a constituent molecule of the triglyceride-rich lipoproteins and participates in their clearance. Polymorphisms in the apo E gene are associated with increased fasting and postprandial levels of triglycerides. We studied 66 patients with the metabolic syndrome, none of whom had diabetes. Details were recorded for cholesterol, triglycerides, apo AI, apo B, insulin, homeostasis model assessment of insulin resistance, homeostasis model assessment of insulin secretion, uric acid, 24-h uric acid urinary excretion, high-density lipoprotein cholesterol, waist to hip ratio, body mass index, and age. The patients were given a 60-g fat overload (Supracal), and measurements were made at 4 h of cholesterol, triglycerides, high-density lipoprotein cholesterol, apo AI, and apo B. Patients who did not have the E3/3 genotype had an odds ratio of postprandial hypertriglyceridemia of 6.2 (confidence interval, 1.41–16.08; P = 0.01) and an odds ratio of hyperuricemia compared with the E3/3-positive patients of 7.5 (confidence interval, 1.04–39.31; P = 0.02). This study shows that patients with the metabolic syndrome who do not have the E3/3 genotype have a greater risk of hyperuricemia and postprandial hypertriglyceridemia after a fat overload.

This article has been cited by other articles:

				F. Cardona, S. Morcillo, M. Gonzalo-Marin, L. Garrido-Sanchez, M. Macias-Gonzalez, and F. J. Tinahones Pro12Ala Sequence Variant of the PPARG Gene Is Associated with Postprandial Hypertriglyceridemia in Non-E3/E3 Patients with the Metabolic Syndrome Clin. Chem., October 1, 2006; 52(10): 1920 - 1925. [Abstract] [Full Text] [PDF]