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Journal of Clinical Endocrinology & Metabolism , doi:10.1210/jc.2004-1978
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The Journal of Clinical Endocrinology & Metabolism Vol. 90, No. 4 2456-2465
Copyright © 2005 by The Endocrine Society


CLINICAL REVIEW

Osteoporosis after Solid Organ Transplantation

Naim M. Maalouf and Elizabeth Shane

Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center (N.M.M.), Dallas, Texas 75390; and Department of Medicine, Columbia-Presbyterian Medical Center and College of Physicians and Surgeons, Columbia University (E.S.), New York, New York 10032

Address all correspondence and requests for reprints to: Dr. Elizabeth Shane, Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8–864, 630 West 168th Street, New York, New York 10032. E-mail: es54{at}columbia.edu.

With the rapid increase in the number of organs transplanted worldwide and the improved survival of transplant recipients, osteoporosis has emerged as a frequent complication of the transplantation process. In the past decade, the wider recognition of transplantation-related osteoporosis has led to a decrease in the risk of fracture for the individual patient. Nonetheless, fracture rates remain unacceptably high in transplant recipients. This presentation reviews the epidemiology of transplantation-related osteoporosis, the factors contributing to the pathogenesis of this complication, and the evaluation, prevention, and treatment options available for kidney, liver, lung, and heart transplant recipients.




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