| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Tage Hansensgade 2, DK-8000 Aarhus C, Denmark
Address all correspondence and requests for reprints to: Jens M. Bruun, M.D., Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus Sygehus, Tage Hansensgade 2, DK-8000 Aarhus C, Denmark. E-mail: Jens.Bruun{at}ki.au.dk.
Human adipose tissue (AT) produces several adipokines including monocyte chemoattractant protein (MCP)-1, involved in the pathogenesis of atherosclerosis.
Objective: Human AT cultures, isolated adipocytes, and stromal-vascular cells were used to investigate the relationship among AT-resident macrophages, MCP-1, and adiposity and the regulation of MCP-1.
Results: mRNA levels of specific macrophage markers (CD68 and CD14) are correlated with adiposity in sc AT and visceral AT (P < 0.05). MCP-1 production is higher in stromal-vascular cells vs. adipocytes (P < 0.01) and correlates with macrophage markers in both AT compartments (P < 0.05). MCP-1 release is higher in obese subjects (P < 0.05) and in VAT (P < 0.01), but after adjusting for AT-resident macrophages, the differences disappear. MCP-1 is stimulated by IL-1ß, TNF-
, IL-8, IL-4, and IL-6 + IL-6-soluble receptor and is decreased by dexamethasone, IL-10, metformin, and thiazolidinediones.
Discussion: MCP-1 is correlated with specific macrophage markers, adiposity, and AT localization, but the relationship seems to be related to the number of AT-resident macrophages. Despite this, MCP-1 may be involved in obesity-related health complications, and the decrease of MCP-1 by metformin and thiazolidinediones suggests that these antidiabetic compounds have antiinflammatory properties improving the low-grade inflammatory state observed in obesity.
This article has been cited by other articles:
 |
|
 |
|
  J. C. Strum, J. H. Johnson, J. Ward, H. Xie, J. Feild, A. Hester, A. Alford, and K. M. Waters MicroRNA 132 Regulates Nutritional Stress-Induced Chemokine Production through Repression of SirT1 Mol. Endocrinol., November 1, 2009; 23(11): 1876 - 1884. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Asamizu, M. Urakaze, C. Kobashi, M. Ishiki, A. K. Norel Din, S. Fujisaka, Y. Kanatani, A. Bukahari, S. Senda, H. Suzuki, et al. Angiotensin II enhances the increase in monocyte chemoattractant protein-1 production induced by tumor necrosis factor-{alpha} from 3T3-L1 preadipocytes J. Endocrinol., August 1, 2009; 202(2): 199 - 205. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sam, S. Haffner, M. H. Davidson, R. B. D'Agostino Sr., S. Feinstein, G. Kondos, A. Perez, and T. Mazzone Relation of Abdominal Fat Depots to Systemic Markers of Inflammation in Type 2 Diabetes Diabetes Care, May 1, 2009; 32(5): 932 - 937. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B.-S. Youn, S.-I. Bang, N. Kloting, J. W. Park, N. Lee, J.-E. Oh, K.-B. Pi, T. H. Lee, K. Ruschke, M. Fasshauer, et al. Serum Progranulin Concentrations May Be Associated With Macrophage Infiltration Into Omental Adipose Tissue Diabetes, March 1, 2009; 58(3): 627 - 636. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Compher and K. O. Badellino Obesity and Inflammation: Lessons From Bariatric Surgery JPEN J Parenter Enteral Nutr, November 1, 2008; 32(6): 645 - 647. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Phillips, T. P. Ciaraldi, Deborah. K. Oh, M. K. Savu, and R. R. Henry Adiponectin secretion and response to pioglitazone is depot dependent in cultured human adipose tissue Am J Physiol Endocrinol Metab, October 1, 2008; 295(4): E842 - E850. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Stienstra, C. Duval, S. Keshtkar, J. van der Laak, S. Kersten, and M. Muller Peroxisome Proliferator-activated Receptor {gamma} Activation Promotes Infiltration of Alternatively Activated Macrophages into Adipose Tissue J. Biol. Chem., August 15, 2008; 283(33): 22620 - 22627. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Huber, F. W. Kiefer, M. Zeyda, B. Ludvik, G. R. Silberhumer, G. Prager, G. J. Zlabinger, and T. M. Stulnig CC Chemokine and CC Chemokine Receptor Profiles in Visceral and Subcutaneous Adipose Tissue Are Altered in Human Obesity J. Clin. Endocrinol. Metab., August 1, 2008; 93(8): 3215 - 3221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Westerbacka, A. Corner, M. Kolak, J. Makkonen, U. Turpeinen, A. Hamsten, R. M. Fisher, and H. Yki-Jarvinen Insulin regulation of MCP-1 in human adipose tissue of obese and lean women Am J Physiol Endocrinol Metab, May 1, 2008; 294(5): E841 - E845. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Takahashi, S. Yamaguchi, T. Shimoyama, H. Seki, K. Miyokawa, H. Katsuta, T. Tanaka, K. Yoshimoto, H. Ohno, S. Nagamatsu, et al. JNK- and I{kappa}B-dependent pathways regulate MCP-1 but not adiponectin release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro Am J Physiol Endocrinol Metab, May 1, 2008; 294(5): E898 - E909. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. L Madsen, A. Rissanen, J. M Bruun, K. Skogstrand, S. Tonstad, D. M Hougaard, and B. Richelsen Weight loss larger than 10% is needed for general improvement of levels of circulating adiponectin and markers of inflammation in obese subjects: a 3-year weight loss study Eur. J. Endocrinol., February 1, 2008; 158(2): 179 - 187. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Stokes and A. Surprenant Purinergic P2Y2 Receptors Induce Increased MCP-1/CCL2 Synthesis and Release from Rat Alveolar and Peritoneal Macrophages J. Immunol., November 1, 2007; 179(9): 6016 - 6023. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. R. Zhou, E.-K. Kim, H. Kim, and K. J. Claycombe Obesity-associated mouse adipose stem cell secretion of monocyte chemotactic protein-1 Am J Physiol Endocrinol Metab, November 1, 2007; 293(5): E1153 - E1158. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Y. Kim, Y. Wu, and C. M. Smas Characterization of ScAP-23, a new cell line from murine subcutaneous adipose tissue, identifies genes for the molecular definition of preadipocytes Physiol Genomics, October 19, 2007; 31(2): 328 - 342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M Bruun, B. Stallknecht, J. W Helge, and B. Richelsen Interleukin-18 in plasma and adipose tissue: effects of obesity, insulin resistance, and weight loss Eur. J. Endocrinol., October 1, 2007; 157(4): 465 - 471. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Pou, J. M. Massaro, U. Hoffmann, R. S. Vasan, P. Maurovich-Horvat, M. G. Larson, J. F. Keaney Jr, J. B. Meigs, I. Lipinska, S. Kathiresan, et al. Visceral and Subcutaneous Adipose Tissue Volumes Are Cross-Sectionally Related to Markers of Inflammation and Oxidative Stress: The Framingham Heart Study Circulation, September 11, 2007; 116(11): 1234 - 1241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Maury, K. Ehala-Aleksejev, Y. Guiot, R. Detry, A. Vandenhooft, and S. M. Brichard Adipokines oversecreted by omental adipose tissue in human obesity Am J Physiol Endocrinol Metab, September 1, 2007; 293(3): E656 - E665. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Murdolo, A. Hammarstedt, M. Sandqvist, M. Schmelz, C. Herder, U. Smith, and P.-A. Jansson Monocyte Chemoattractant Protein-1 in Subcutaneous Abdominal Adipose Tissue: Characterization of Interstitial Concentration and Regulation of Gene Expression by Insulin J. Clin. Endocrinol. Metab., July 1, 2007; 92(7): 2688 - 2695. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Y. Kim, K. Tillison, S. Zhou, Y. Wu, and C. M. Smas The major facilitator superfamily member Slc37a2 is a novel macrophage- specific gene selectively expressed in obese white adipose tissue Am J Physiol Endocrinol Metab, July 1, 2007; 293(1): E110 - E120. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Harman-Boehm, M. Bluher, H. Redel, N. Sion-Vardy, S. Ovadia, E. Avinoach, I. Shai, N. Kloting, M. Stumvoll, N. Bashan, et al. Macrophage Infiltration into Omental Versus Subcutaneous Fat across Different Populations: Effect of Regional Adiposity and the Comorbidities of Obesity J. Clin. Endocrinol. Metab., June 1, 2007; 92(6): 2240 - 2247. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Flynn, B. K. McFarlin, and M. M. Markofski State of the Art Reviews: The Anti-Inflammatory Actions of Exercise Training American Journal of Lifestyle Medicine, May 1, 2007; 1(3): 220 - 235. [Abstract] [PDF]
|
|
|
|
 |
|
 G. Fantuzzi and T. Mazzone Adipose Tissue and Atherosclerosis: Exploring the Connection Arterioscler Thromb Vasc Biol, May 1, 2007; 27(5): 996 - 1003. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E.-M. Sedlmeier, H. Grallert, C. Huth, H. Lowel, C. Herder, K. Strassburger, G. Giani, H-E. Wichmann, H. Hauner, T. Illig, et al. Gene variants of monocyte chemoattractant protein 1 and components of metabolic syndrome in KORA S4, Augsburg Eur. J. Endocrinol., March 1, 2007; 156(3): 377 - 385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Sharma and B. Staels Peroxisome Proliferator-Activated Receptor {gamma} and Adipose Tissue--Understanding Obesity-Related Changes in Regulation of Lipid and Glucose Metabolism J. Clin. Endocrinol. Metab., February 1, 2007; 92(2): 386 - 395. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Lacasa, S. Taleb, M. Keophiphath, A. Miranville, and K. Clement Macrophage-Secreted Factors Impair Human Adipogenesis: Involvement of Proinflammatory State in Preadipocytes Endocrinology, February 1, 2007; 148(2): 868 - 877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. K. Brake, E. O. Smith, H. Mersmann, C. W. Smith, and R. L. Robker ICAM-1 expression in adipose tissue: effects of diet-induced obesity in mice Am J Physiol Cell Physiol, December 1, 2006; 291(6): C1232 - C1239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Bruun, J. W. Helge, B. Richelsen, and B. Stallknecht Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects Am J Physiol Endocrinol Metab, May 1, 2006; 290(5): E961 - E967. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Sander, C. G. Luchetti, M. E. Solano, E. Elia, G. Di Girolamo, C. Gonzalez, and A. B. Motta Role of the N, N'-dimethylbiguanide metformin in the treatment of female prepuberal BALB/c mice hyperandrogenized with dehydroepiandrosterone. Reproduction, March 1, 2006; 131(3): 591 - 602. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Herder, S. Muller-Scholze, P. Rating, W. Koenig, B. Thorand, B. Haastert, R. Holle, T. Illig, W. Rathmann, J. Seissler, et al. Systemic monocyte chemoattractant protein-1 concentrations are independent of type 2 diabetes or parameters of obesity: results from the Cooperative Health Research in the Region of Augsburg Survey S4 (KORA S4) Eur. J. Endocrinol., February 1, 2006; 154(2): 311 - 317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Dahlman, M. Kaaman, T. Olsson, G. D. Tan, A. S. T. Bickerton, K. Wahlen, J. Andersson, E. A. Nordstrom, L. Blomqvist, A. Sjogren, et al. A Unique Role of Monocyte Chemoattractant Protein 1 among Chemokines in Adipose Tissue of Obese Subjects J. Clin. Endocrinol. Metab., October 1, 2005; 90(10): 5834 - 5840. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Suganami, J. Nishida, and Y. Ogawa A Paracrine Loop Between Adipocytes and Macrophages Aggravates Inflammatory Changes: Role of Free Fatty Acids and Tumor Necrosis Factor {alpha} Arterioscler Thromb Vasc Biol, October 1, 2005; 25(10): 2062 - 2068. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Boschmann, S. Engeli, F. Adams, K. Gorzelniak, G. Franke, S. Klaua, U. Kreuzberg, S. Luedtke, R. Kettritz, A. M. Sharma, et al. Adipose Tissue Metabolism and CD11b Expression on Monocytes in Obese Hypertensives Hypertension, July 1, 2005; 46(1): 130 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Malavazos, E. Cereda, L. Morricone, M. M. Corsi, and B. Ambrosi Monocyte Chemoattractant Protein-1 in Adipose Tissue J. Clin. Endocrinol. Metab., May 1, 2005; 90(5): 3128 - 3128. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
