Insulin-Like Growth Factor Binding Protein-1 Is Independently Affected by Ethnicity, Insulin Sensitivity, and Leptin in Healthy, Glucose-Tolerant Young Men
Choon F. Liew,
Stephen D. Wise,
Kwee P. Yeo and
Kok O. Lee
Department of Medicine (C.F.L., K.O.L.), National University Hospital, Singapore 119074; and Lilly-NUS Centre for Clinical Pharmacology (S.D.W., K.P.Y.), National University of Singapore, Singapore 117597
Address all correspondence and requests for reprints to: Professor K. O. Lee, Department of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074. E-mail: mdcleeko{at}nus.edu.sg.
We examined the relationships among IGF binding protein (IGFBP)-1,insulin sensitivity, and leptin in different ethnic groups (AsianIndians, Chinese, and Caucasians) using the euglycemic hyperinsulinemicclamp. Ten healthy, young and nondiabetic subjects of each ethnicgroup, matched for body mass index, age, and physical activitywere studied. A euglycemic clamp was performed on all subjects.IGFBP-1, insulin, and leptin were measured after fasting andduring the clamp. Fasting IGFBP-1 concentration was highestin Chinese (P = 0.027). Asian Indians had the lowest insulinsensitivity index (P = 0.006). The ratio of insulin to IGFBP-1at fasting and throughout the euglycemic clamp was higher inAsian Indians. Fasting IGFBP-1 had a strong negative correlationwith fasting leptin levels (r = –0.715, P = 0.001). Multiplelinear regression demonstrated that fasting insulin, leptin,ethnicity, and insulin sensitivity were significant predictorsfor fasting IGFBP-1. IGFBP-1 is independently determined byethnicity, insulin sensitivity, and leptin in glucose-tolerantmen. The presence of relative insulin resistance and low fastingIGFBP-1 levels in Asian Indians may contribute to their higherrisk of developing diabetes and cardiovascular disease.
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