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Octreotide (Long-Acting Release Formulation) Treatment in Patients with Graves’ Orbitopathy: Clinical Results of a Four-Month, Randomized, Placebo-Controlled, Double-Blind Study

Centre Hospitalier Universitaire (J.L.W., M.N., P.P.), 59037 Lille, France; Centre Hospitalier Universitaire Rangueil (P.C.), 31403 Toulouse, France; Centre Hospitalier Universitaire (A.B.), 400-35, Liège, Belgium; Centre Hospitalier Universitaire (V.R.), 49033 Angers, France; Centre Hospitalier Universitaire (J.O., F.B.-C.), 69495 Lyon, France; Centre Hospitalier Universitaire Saint Pierre, 1000 Bruxelles, Belgium; and Novartis Pharma SAS (S.B.-L., I.B., S.D.), 92506 Rueil Malmaison, France

Address all correspondence and requests for reprints to: Prof. J. L. Wémeau, Clinique Endocrinologique Marc Linquette, Centre Hospitalier Régional Universitaire, 59037 Lille Cedex, France. E-mail: jl-wemeau{at}chru-lille.fr.

There are few effective, safe modalities for the management of Graves’ ophthalmopathy (GO), a cell-mediated immune comorbidity of thyroid disease. Somatostatin analogs inhibit lymphocyte proliferation and activation, and accumulate in the orbital tissue of patients with GO. A double-blind, placebo-controlled study of a long-acting somatostatin analog [16 wk of long-acting release formulation of octreotide (octreotide-LAR)] was conducted in 51 patients with mild active GO with the aim of preventing deterioration and precluding the need for more aggressive therapeutic modalities, such as glucocorticoids or radiotherapy. No treatment effect was observed for the primary end point (a composite parameter defining the outcome as either success or failure on the basis of changes in class/grade of the severity index and Clinical Activity Scale of GO). The Clinical Activity Scale score was reduced for patients treated with octreotide-LAR, but without any significant difference with respect to patients receiving placebo. However, octreotide-LAR significantly reduced proptosis (as measured by exophthalmometry). This was associated with nonsignificant differences in favor of octreotide-LAR in a series of proptosis-related parameters: class III grade, opening of the upper eyelid, the difference in ocular pressure between primary position and upgaze, and extraocular muscle involvement. By magnetic resonance imaging evaluation the extraocular muscle volumes appeared reduced, but nonsignificantly. No significant correlation between the initial uptake of the somatostatin analog indium-labeled and the response to treatment was observed. One patient in the octreotide-LAR group developed gallstones. In this study, octreotide-LAR did not seem suitable to mitigate activity in mild GO. Surprisingly, it significantly reduced proptosis, one of the most debilitating symptoms of GO. Additional studies are warranted to define the benefit to risk ratio of the somatostatin analogs in this indication.

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