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Lack of Effect of Calcium Intake on the 25-Hydroxyvitamin D Response to Oral Vitamin D₃

Division of Endocrinology, Tufts-New England Medical Center (R.G.); and Bone Metabolism Laboratory (L.S., B.D.-H.), and Biostatistics Department (G.E.D.), Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111

Address all correspondence and requests for reprints to: Dr. Bess Dawson-Hughes, Bone Metabolism Laboratory at the Jean Mayer, U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, Massachusetts 02111. E-mail: bess.dawson-hughes{at}tufts.edu.

This study was conducted to examine the effect of calcium intake on the rise in serum 25-hydroxyvitamin D [25(OH)D] levels in response to supplemental vitamin D₃. Fifty-two healthy older men and women were randomly assigned to take calcium (500 mg twice daily with meals) or placebo tablets for 90 d between October 1 and the end of March. All participants were placed on 800 IU/d (20 µg/d) vitamin D₃. Serum 25(OH)D measurements were made at baseline and on d 30, 60, and 90. The mean baseline 25(OH)D values were 19.2 ± 6.4 ng/ml (47.9 ± 15.9 nmol/liter) in the calcium group and 19.6 ± 6.7 ng/ml (49.1 ± 16.7 nmol/liter) in the control group (P = 0.808). The difference in pattern of change in 25(OH)D was not statistically significant (group by time interaction, P = 0.651); the calcium group increased 6.5 ± 5.9 ng/ml (16.2 ± 14.8 nmol/liter; P < 0.001), and the control group increased 6.6 ± 7.0 ng/ml (16.6 ± 17.4 nmol/liter; P < 0.001). The 95% confidence interval for difference in mean increase, calcium vs. control, was –3.8 ± 3.5 ng/ml (–9.6, 8.7) nmol/liter. In older men and women, the level of calcium intake, within the range of 500-1500 mg/d, does not have an important effect on the rise in serum 25(OH)D that occurs in response to 800 IU (20 µg)/d vitamin D₃.

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