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Division of Endocrinology, Metabolism, and Molecular Medicine (M.U., A.D.), Northwestern University Medical School, Chicago, Illinois 60611; Department of Genetics (A.W., K.G.E., R.S.S.) and Center for Research on Reproduction and Women’s Health and Department of Obstetrics and Gynecology (J.F.S.), University of Pennsylvania, Philadelphia, Pennsylvania 19104; Endocrine Section, First Department of Internal Medicine (E.D.-K.), Athens University School of Medicine, Athens, Greece; and Department of Obstetrics and Gynecology (R.S.L.), Pennsylvania State University, Hershey, Pennsylvania 17033
Address all correspondence and requests for reprints to: Dr. Margrit Urbanek, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University School of Medicine, 303 East Chicago Avenue, Tarry 15-717, Chicago, Illinois 60611. E-mail: m-urbanek{at}northwestern.edu.
Context: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that is believed to have a genetic basis. However, no specific susceptibility gene or region has been conclusively identified.
Objective: The objective of this study was to duplicate a previous study that localized a PCOS susceptibility region to chromosome 19p13.2 and to narrow the susceptibility region.
Design: This study was designed to test for genetic linkage and association between PCOS and short tandem repeat polymorphisms in 367 families, by analysis of linkage and family-based association.
Setting: The study was conducted at academic medical centers.
Patients or Other Participants: We studied 367 families of predominantly European origin with at least one PCOS patient. Families included 107 affected sibling (sister) pairs (ASPs) in 83 families, and 390 trios with both parents and an affected daughter. The data set comprises two independent groups. Set 1 consists of 44 ASPs and 163 trios. Set 2 consists of 63 ASPs and 227 trios.
Intervention(s): The intervention was the drawing of blood for DNA extraction.
Main Outcome Measure: We employed measures of evidence for linkage and association between PCOS and 19 STRs.
Results: Linkage with PCOS was observed over a broad region of chromosome 19p13.2. The strongest evidence for association was observed with D19S884 (
2=11.85; nominal P < 0.0006; permutation P = 0.034) and duplicated our earlier findings.
Conclusions: The present analysis suggests that a PCOS susceptibility locus maps very close to D19S884. Additional studies that systematically characterize DNA sequence variation in the immediate area of D19S884 are required to identify the PCOS susceptibility variant.
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