This Article Full Text Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nguyen, T. V. Articles by Eisman, J. A. Search for Related Content PubMed PubMed Citation Articles by Nguyen, T. V. Articles by Eisman, J. A. Related Collections Calcium and Bone Metabolism

Contribution of the Collagen I 1 and Vitamin D Receptor Genes to the Risk of Hip Fracture in Elderly Women

Bone and Mineral Research Program, Garvan Institute of Medical Research, St. Vincent’s Hospital, Sydney, New South Wales 2010, Australia

Address all correspondence and requests for reprints to: Dr. Tuan V. Nguyen, Bone and Mineral Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia. E-mail: t.nguyen{at}garvan.org.au.

Context and Objective: Hip fracture is partially genetically determined. The present study was designed to examine the contributions of vitamin D receptor (VDR) and collagen I 1 (COLIA1) genotypes to the liability to hip fracture in postmenopausal women.

Design: The study was designed as a prospective population-based cohort investigation.

Subjects: Six hundred seventy-seven postmenopausal women of Caucasian background, aged 70 ± 7 yr (mean ± SD), have been followed for up to 14 yr. Sixty-nine women had sustained a hip fracture during the period.

Main Outcome: Atraumatic hip fractures were prospectively identified through radiologists’ reports. Bone mineral density (BMD) at the hip and lumbar spine was measured by dual-energy x-ray absorptiometry.

Genotypes: The TaqI and SpI COLIA1 polymorphisms of the VDR and COLIA1 genes were determined. Using the Single Nucleotide Polymorphism database, VDR TT, Tt, and tt genotypes were coded as TT, TC, and CC, whereas COLIA1 SS, Ss, and ss were coded as GG, GT, and TT.

Results: Women with VDR CC genotype (16% prevalence) and COLIA1 TT genotype (5% prevalence) had an increased risk of hip fracture [odds ratio (OR) associated with CC, 2.6; 95% confidence interval (CI), 1.2–5.3; OR associated with TT, 3.8; 95% CI, 1.3–10.8] after adjustment for femoral neck BMD (OR, 3.4 per SD; 95% CI, 2.3–5.0) and age (OR, 1.4 per 5 yr; 95% CI, 1.1–1.7). Approximately 20 and 12% of the liability to hip fracture was attributable to the presence of the CC genotype and TT genotype, respectively.

Conclusion: The VDR CC genotype and COLIA1 TT genotype were associated with increased hip fracture risk in Caucasian women, and this association was independent of BMD and age.

This article has been cited by other articles:

				Y. Fang, J. B. J. van Meurs, F. Rivadeneira, N. M. van Schoor, J. P. T. van Leeuwen, P. Lips, H. A. P. Pols, and A. G. Uitterlinden Vitamin D Receptor Gene Haplotype Is Associated with Body Height and Bone Size J. Clin. Endocrinol. Metab., April 1, 2007; 92(4): 1491 - 1501. [Abstract] [Full Text] [PDF]

				M. Rao Vupputuri, R. Goswami, N. Gupta, D. Ray, N. Tandon, and N. Kumar Prevalence and functional significance of 25-hydroxyvitamin D deficiency and vitamin D receptor gene polymorphisms in Asian Indians Am. J. Clinical Nutrition, June 1, 2006; 83(6): 1411 - 1419. [Abstract] [Full Text] [PDF]