This Article Full Text Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints, Permissions and Rights Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fatouros, I. G. Articles by Mitrakou, A. Search for Related Content PubMed PubMed Citation Articles by Fatouros, I. G. Articles by Mitrakou, A. Related Collections Cardiovascular Endocrinology Metabolism Obesity

Leptin and Adiponectin Responses in Overweight Inactive Elderly following Resistance Training and Detraining Are Intensity Related

Department of Physical Education and Sports Science, Democritus University of Thrace (I.G.F., P.T., I.D., K.T.), Komotini 69100, Greece; Diabetes and Metabolism Unit (S.T., D.L., A.M.), and Department of Biochemistry (M.M.), Henry Dunant Hospital, Athens 11526, Greece; Department of Physical Education and Sports Sciences, University of Thessaly (A.Z.J.), Trikala 42100, Greece; and Department of Pediatrics, University Hospital of Alexandroupolis (M.S.), Dragana, Alexandroupolis 68100, Greece

Address all correspondence and requests for reprints to: Dr. Ioannis G. Fatouros, Department of Physical Education and Sports Science, 7th km of of National Road Komotini-Xanthi, Komotini 69100, Greece. E-mail: fatouros{at}otenet.gr.

Context: Adiponectin and leptin are closely related to weight control and energy balance, whereas exercise affects elderly metabolic regulation and functional capacity.

Objective: The objective of this study was to investigate leptin and adiponectin responses in elderly males after exercise training and detraining.

Design: The study design was a 1-yr randomized controlled trial.

Setting: The study was performed at the Laboratory of Physical Education and Sport Science Department.

Participants: Fifty inactive men [age, 65–78 yr; body mass index (BMI), 28.7–30.2 kg/m²] were recruited from a volunteer database by word of mouth and fliers sent to medical practitioners, physiotherapists, and nursing homes in the local community.

Intervention(s): Participants were randomly assigned to a control (n = 10), low-intensity (n = 14), moderate-intensity (n = 12), or high-intensity training (HI; n = 14) group. Resistance training (6 months, 3 d/wk, 10 exercises/three sets) was followed by 6 months of detraining.

Main Outcome Measure(s): Strength, exercise energy cost, skinfold sum, body weight, maximal oxygen consumption, resting metabolic rate (RMR), and plasma leptin and adiponectin were determined at baseline and after training and detraining.

Results: Strength, maximal oxygen consumption, RMR, and exercise energy cost increased (P < 0.05) after training in an intensity-dependent manner. Skinfold sum and BMI were reduced by resistance training (P < 0.05), with HI being more effective (P < 0.05) than moderate-intensity/low-intensity training. Leptin was diminished (P < 0.05) by all treatments, whereas adiponectin increased (P < 0.05) only in HI. Detraining maintained training-induced changes only in HI. The percent leptin decrease was associated (P < 0.05) with the percent BMI decrease and the percent RMR increase, whereas the percent adiponectin increase was associated (P < 0.05) with the percent BMI decrease.

Conclusions: Resistance training and detraining may alter leptin and adiponectin responses in an intensity-dependent manner. Leptin and adiponectin changes were strongly associated with RMR and anthropometric changes.

This article has been cited by other articles:

				I. G. Fatouros, A. Chatzinikolaou, S. Tournis, M. G. Nikolaidis, A. Z. Jamurtas, I. I. Douroudos, I. Papassotiriou, P. M. Thomakos, K. Taxildaris, G. Mastorakos, et al. Intensity of Resistance Exercise Determines Adipokine and Resting Energy Expenditure Responses in Overweight Elderly Individuals Diabetes Care, December 1, 2009; 32(12): 2161 - 2167. [Abstract] [Full Text] [PDF]

				A. Chatzinikolaou, I. Fatouros, A. Petridou, A. Jamurtas, A. Avloniti, I. Douroudos, G. Mastorakos, C. Lazaropoulou, I. Papassotiriou, S. Tournis, et al. Adipose Tissue Lipolysis Is Upregulated in Lean and Obese Men During Acute Resistance Exercise Diabetes Care, July 1, 2008; 31(7): 1397 - 1399. [Abstract] [Full Text] [PDF]

				S. Ahmadizad, A. H. Haghighi, and M. R. Hamedinia Effects of resistance versus endurance training on serum adiponectin and insulin resistance index Eur. J. Endocrinol., November 1, 2007; 157(5): 625 - 631. [Abstract] [Full Text] [PDF]

				R. R. Kraemer and V. D. Castracane Exercise and Humoral Mediators of Peripheral Energy Balance: Ghrelin and Adiponectin Exp Biol Med, February 1, 2007; 232(2): 184 - 194. [Abstract] [Full Text] [PDF]

				M. Bluher, J. W. Bullen Jr., J. H. Lee, S. Kralisch, M. Fasshauer, N. Kloting, J. Niebauer, M. R. Schon, C. J. Williams, and C. S. Mantzoros Circulating Adiponectin and Expression of Adiponectin Receptors in Human Skeletal Muscle: Associations with Metabolic Parameters and Insulin Resistance and Regulation by Physical Training J. Clin. Endocrinol. Metab., June 1, 2006; 91(6): 2310 - 2316. [Abstract] [Full Text] [PDF]

				N. Moriconi, M. Kraenzlin, B. Muller, U. Keller, C. P. G. Nusbaumer, S. Stohr, M. Tamm, and J. J. Puder Body Composition and Adiponectin Serum Concentrations in Adult Patients with Cystic Fibrosis J. Clin. Endocrinol. Metab., April 1, 2006; 91(4): 1586 - 1590. [Abstract] [Full Text] [PDF]