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Journal of Clinical Endocrinology & Metabolism , doi:10.1210/jc.2004-1083
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The Journal of Clinical Endocrinology & Metabolism Vol. 90, No. 1 198-202
Copyright © 2005 by The Endocrine Society

Increased Cerebrospinal Fluid Levels of 3,3',5'-Triiodothyronine in Patients with Alzheimer’s Disease

Simone Sampaolo, Angel Campos-Barros, Gherardo Mazziotti, Sergio Carlomagno, Vincenzo Sannino, Giovanni Amato, Carlo Carella and Giuseppe Di Iorio

Department of Neurological Sciences (S.S., V.S., G.D.I.), and Department of Clinical and Experimental Medicine, F. Magrassi and A. Lanzara (G.M., G.A., C.C.), Second University of Naples, 80138 Naples, Italy; Department of Pediatric Endocrinology, Hospital Infantil Universitario Niño Jesús, Universidad Autónoma (A.C.-B.), E-28009 Madrid, Spain; and Department of Psychology, University of Trieste (S.C.), 34100 Trieste, Italy

Address all correspondence and requests for reprints to: Dr. Simone Sampaolo, Dipartimento di Scienze Neurologiche, Seconda Università degli Studi di Napoli, Piazza Miraglia 2, 80138 Naples, Italy. E-mail: simone.sampaolo{at}unina2.it.

Cerebrospinal fluid (CSF) levels of rT3 were evaluated in 21 euthyroid patients with overt Alzheimer’s disease (AD) and 18 matched healthy controls. The assessment also included trans-thyretin and total T3 and T4 CSF concentrations. Despite normal circulating thyroid hormone levels, AD subjects showed significantly increased rT3 levels and an increased rT3 to T4 ratio in the face of unchanged CSF total T4 and transthyretin levels. These results suggest an abnormal intracerebral thyroid hormone metabolism and possibly the occurrence of brain hypothyroidism, either as a secondary consequence of the ongoing process or as a cofactor in the progression of the disease.




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