This Article Full Text Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kamel, A. F. Articles by Marcus, C. Search for Related Content PubMed PubMed Citation Articles by Kamel, A. F. Articles by Marcus, C.

Age-Dependent Regulation of Lipogenesis in Human and Rat Adipocytes

Department of Pediatrics (A.F.K., S.N., C.M.), Endocrine Research Unit, and Department of Surgery (K.S., A.T.), Huddinge University Hospital, S-141 86 Huddinge, Sweden; and Department of Molecular Medicine (H.F.-R., J.G.), Karolinska Hospital, L 602, S-171 76 Stockholm, Sweden

Address all correspondence and requests for reprints to: Professor Dr. Claude Marcus, Department of Pediatrics, National Childhood Obesity Centre, Children’s Hospital, Huddinge University Hospital, Karolinska Institute, S-141 86 Huddinge, Sweden. E-mail: claude.marcus{at}hs.se.

The regulation of adipocyte metabolism is of importance for adipose tissue growth and therefore also for the development of obesity. This study was designed to investigate the regulation of basal and insulin-induced lipogenesis, glucose transport, and glucose transporter protein expression in human and rat adipocytes from different age groups.

The study included 21 infants, 21 children, nine adults, and 80 male weaned and 20 male adult Fischer rats. The lipogenesis experiments were performed under conditions at which glucose transport is rate limiting. Basal lipogenesis was approximately three times higher in infants and children than in adults, whereas insulin-induced lipogenesis was two times higher in infants than in children and adults. In rats, basal lipogenesis, insulin-induced lipogenesis, and insulin sensitivity were two times higher in weaned than in adult animals. Moreover, basal and insulin-induced glucose transport were two times higher in weaned than in adult rats. No differences were detected in GLUT1 or GLUT4 content between any of the age groups in human or in rat adipocytes.

In conclusion, basal and insulin-stimulated lipogenesis are increased in adipocytes early in life. This may promote adipose tissue growth in early age. The data indicate that age-dependent variation in basal and insulin-stimulated lipogenesis is differently regulated.

This article has been cited by other articles:

				A. Carruthers, J. DeZutter, A. Ganguly, and S. U. Devaskar Will the original glucose transporter isoform please stand up! Am J Physiol Endocrinol Metab, October 1, 2009; 297(4): E836 - E848. [Abstract] [Full Text] [PDF]

				M. Grohmann, M. Sabin, J. Holly, J. Shield, E. Crowne, and C. Stewart Characterization of differentiated subcutaneous and visceral adipose tissue from children: the influences of TNF-{alpha} and IGF-I J. Lipid Res., January 1, 2005; 46(1): 93 - 103. [Abstract] [Full Text] [PDF]