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The Journal of Clinical Endocrinology & Metabolism Vol. 89, No. 9 4588-4593
Copyright © 2004 by The Endocrine Society

Early Impairment of Endothelial Structure and Function in Young Normal-Weight Women with Polycystic Ovary Syndrome

Francesco Orio, Jr., Stefano Palomba, Teresa Cascella, Biagio De Simone, Sebastiano Di Biase, Tiziana Russo, Donato Labella, Fulvio Zullo, Gaetano Lombardi and Annamaria Colao

Department of Molecular & Clinical Endocrinology and Oncology (F.O., T.C., G.L., A.C.) and Institute of Internal Medicine and Metabolic Disease (B.D.S.), University "Federico II", 80131 Naples, Italy; Department of Obstetrics and Gynecology (S.P., T.R., F.Z.), University of Catanzaro "Magna Graecia", 88100 Catanzaro, Italy; and "MeriGen" Laboratory of Molecular Biology (S.D.B., D.L.), 80131 Naples, Italy

Address all correspondence and requests for reprints to: Francesco Orio, M.D., Department of Molecular & Clinical Endocrinology and Oncology, University "Federico II" of Naples, Via S. Pansini 5, 80131 Naples, Italy. E-mail: francescoorio{at}virgilio.it.

The aim of this study was to evaluate the presence of early vascular damage in young normal-weight women with polycystic ovary syndrome (PCOS).

Thirty young normal-weight women with PCOS, who had no additional metabolic or cardiovascular diseases, and 30 healthy women (controls) matched for age and body mass index were studied. A complete hormonal assay was performed in each subject. Serum insulin and glucose levels were measured at baseline and after the oral glucose tolerance test. Plasma endothelin-1 levels and serum lipid profile were also assessed. The endothelial function was studied by flow-mediated dilation on the brachial artery, and arterial structure was evaluated by intima-media thickness measurement using Doppler ultrasound of both common carotid arteries.

A significant (P < 0.05) difference in flow-mediated dilation (14.3 ± 1.9% vs. 18.1 ± 2.0% for PCOS patients and controls, respectively) and in intima-media thickness (0.53 ± 0.09 mm vs. 0.39 ± 0.08 mm for PCOS patients and controls, respectively) was found between PCOS and control subjects. Serum endothelin-1 levels were also significantly (P < 0.05) higher in PCOS patients compared with controls (1.1 ± 0.4 pmol/liter vs. 0.5 ± 0.2 pmol/liter for PCOS patients and controls, respectively).

In conclusion, our data show that young, normal-weight, nondyslipidemic, nonhypertensive women with PCOS have an early impairment of endothelial structure and function.




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