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Serum Levels of Matrix Extracellular Phosphoglycoprotein (MEPE) in Normal Humans Correlate with Serum Phosphorus, Parathyroid Hormone and Bone Mineral Density

Division of Geriatric Medicine (A.J., N.S.F., M.A.A.), Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21224; General Clinical Research Center (N.S.F., R.G., M.T.), Johns Hopkins Bayview Medical Center, Baltimore Maryland 21224; and Craniofacial and Skeletal Diseases Branch (M.T.C., L.W.F.), National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, Maryland 20892

Address all correspondence and requests for reprints to: Neal S. Fedarko, Division of Geriatric Medicine, Johns Hopkins Bayview Medical Center, 5501 Hopkins Bayview Circle, Room 5B 79 JHAAC, Baltimore, Maryland 21224. E-mail: ndarko{at}welchlink.welch.jhu.edu

Abstract

Matrix extracellular phosphoglycoprotein (MEPE), a member of the Small Integrin Binding Ligand N-linked Glycoprotein (SIBLING) family, is primarily expressed in normal bone and has been proposed as a phosphaturic factor because of high expression and secretion in oncogenic hypophosphatemic osteomalacia tumors. In order to begin to address the role of MEPE in normal human physiology, we developed a competitive ELISA to measure serum levels of MEPE. The ELISA was used to characterize the distribution pattern in a population consisting of 114 normal adult subjects. The mean value of MEPE was 476 ± 247 ng/ml and levels decreased significantly with increasing age. MEPE levels were also significantly correlated with serum phosphorus and parathyroid hormone (PTH). In addition, MEPE levels correlated significantly with measures of bone mineral density in the femoral neck and total hip in a subset of 50 elderly subjects. The results are consistent with MEPE being involved in phosphate and bone metabolism in a normal population.

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