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The Journal of Clinical Endocrinology & Metabolism Vol. 89, No. 8 4119-4123
Copyright © 2004 by The Endocrine Society

Presence of Luteinizing Hormone/Human Chorionic Gonadotropin Receptors in Male Breast Tissues

Harold E. Carlson, Philip Kane, Z. M. Lei, X. Li and C. V. Rao

Departments of Medicine (H.E.C.) and Pathology (P.K.), Stony Brook University, Stony Brook, New York 11794; and Department of Obstetrics, Gynecology and Women’s Health (Z.M.L., X.L., C.V.R.), University of Louisville, Louisville, Kentucky 40292

Address all correspondence and requests for reprints to: Harold E. Carlson, M.D., Endocrinology Division, HSC T15-060, Stony Brook University, Stony Brook, New York 11794-8154. E-mail: hcarlson{at}notes.cc.sunysb.edu.

Receptors for LH/human chorionic gonadotropin (hCG) have been found in a variety of nongonadal tissues including the female breast. Using in situ hybridization and immunohistochemistry, we demonstrated the presence of LH/hCG receptor mRNA and protein in normal male breast tissue obtained at autopsy (n = 4) and archival samples of benign gynecomastia (n = 14) and male breast carcinoma (n = 5). Although the function of these receptors remains to be determined, the findings suggest the possibility that LH and hCG may play a role in the pathogenesis of male breast disorders.

Abbreviations: hCG, Human chorionic gonadotropin; IHC, immunohistochemistry; ISH, in situ hybridization; SSC, sodium chloride/sodium citrate.




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