Adiponectin before and after Weight Loss in Obese Children
T. Reinehr,
C. Roth,
T. Menke and
W. Andler
Vestische Kinder- und Jugendklinik Datteln, University of Witten-Herdecke (T.R., T.M., W.A.), 45711 Datteln, Germany; and Department of Pediatrics, University of Bonn (C.R.), 53113 Bonn, Germany
Address all correspondence and requests for reprints to: Dr. Thomas Reinehr, Vestische Kinder- und Jugendklinik, University of Witten-Herdecke, Dr. F. Steiner Strasse 5, 45711 Datteln, Germany. E-mail: t.reinehr{at}kinderklinik-datteln.de.
Adiponectin is decreased in obesity and seems to be involvedin insulin resistance. The influences of age, gender, puberty,and weight loss on adiponectin have not been studied in obesechildren. We measured body fat mass based on skinfold thickness,age, pubertal stage, gender, adiponectin, and insulin resistance(homeostasis model assessment) in 42 obese children. We analyzedadiponectin and homeostasis model assessment 1 yr later in theseobese children and separated them into two groups accordingto degree of weight loss (decrease in SD score for body massindex, 0.5 vs. <0.5). Adiponectin was negatively correlatedto percentage body fat (r = –0.44; P = 0.002), insulinresistance (r = –0.33; P = 0.016), and age (r = –0.41;P = 0.003). Adiponectin levels were significantly (P = 0.017)higher in pubertal girls compared with boys, but there was nosignificant difference in prepubertal children in respect togender (P = 0.833). Adiponectin was significantly (P < 0.001)lower in pubertal compared with prepubertal children. The significantweight loss in 16 children was associated with a significantincrease in adiponectin (P = 0.010) and a decrease in insulinresistance (P = 0.013), whereas there were no changes in the26 children without significant weight loss. Adiponectin levelsin obese children were negatively correlated to age, body fat,and insulin resistance and were decreased in puberty. Significantweight loss led to an increase in adiponectin levels and animprovement of insulin resistance.
Abbreviations: BMI, Body mass index; HOMA, homeostasis modelassessment; SDS, SD score.
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0.5 vs. <0.5). Adiponectin was negatively correlated to percentage body fat (r = –0.44; P = 0.002), insulin resistance (r = –0.33; P = 0.016), and age (r = –0.41; P = 0.003). Adiponectin levels were significantly (P = 0.017) higher in pubertal girls compared with boys, but there was no significant difference in prepubertal children in respect to gender (P = 0.833). Adiponectin was significantly (P < 0.001) lower in pubertal compared with prepubertal children. The significant weight loss in 16 children was associated with a significant increase in adiponectin (P = 0.010) and a decrease in insulin resistance (P = 0.013), whereas there were no changes in the 26 children without significant weight loss. Adiponectin levels in obese children were negatively correlated to age, body fat, and insulin resistance and were decreased in puberty. Significant weight loss led to an increase in adiponectin levels and an improvement of insulin resistance. 
