| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Research Centre for Endocrinology and Metabolism (J.S., B.-Å.B., T.R., G.J.), Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden; and consulting statistician (A.O.), SE-44292 Romelanda, Sweden
Address all correspondence and requests for reprints to: Johan Svensson, M.D., Research Centre for Endocrinology and Metabolism, Gröna Stråket 8, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden. E-mail: Johan.Svensson{at}medic.gu.se.
A retrospective comparison was performed between 1411 hypopituitary adults without GH replacement [mean age, 56.9 (SD 18.6) yr] and the normal population in terms of fatal and nonfatal morbidity. A similar prospective comparison was then made in 289 hypopituitary patients on long-term GH replacement [mean age, 47.6 (SD 14.8) yr; mean duration of GH treatment, 60 months].
In the 1411 hypopituitary patients without GH replacement, overall mortality (P < 0.001), and the rates of myocardial infarctions (P < 0.01), cerebrovascular events (P < 0.001), and malignancies (P < 0.001) were increased compared with the normal population. Colorectal cancer was the most common malignancy in this cohort (P < 0.001 vs. the background population). In the 289 hypopituitary patients on GH replacement, overall mortality and the rate of malignancies were similar to the normal population. In the hypopituitary adults on GH therapy, the rate of myocardial infarctions was lower than that in the background population (P < 0.05), and there was a tendency toward an increased rate of cerebrovascular events.
In conclusion, overall mortality and the rate of myocardial infarctions were increased in hypopituitary patients without GH replacement. An increased rate of malignancies was observed in the hypopituitary adults without GH therapy, with a predominance of colorectal cancer. GH replacement appeared to provide protection from myocardial infarctions. The rate of cerebrovascular events tended to be increased also in hypopituitary adults on GH therapy.
This study was supported by the chair of Göteborg and the Novo Nordisk Foundation.
Results of this work were presented in part at the 85th Annual Meeting of The Endocrine Society, Philadelphia, Pennsylvania, June 2003.
Abbreviation: IGFBP-3, IGF-binding protein-3.
This article has been cited by other articles:
 |
|
 |
|
  D S Olsson, M Buchfelder, S Schlaffer, B-A Bengtsson, K-E Jakobsson, G Johannsson, and A G Nilsson Comparing progression of non-functioning pituitary adenomas in hypopituitarism patients with and without long-term GH replacement therapy Eur. J. Endocrinol., November 1, 2009; 161(5): 663 - 669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Svensson and B.-A. Bengtsson Safety aspects of GH replacement Eur. J. Endocrinol., November 1, 2009; 161(S1): S65 - S74. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Verhelst and R. Abs Cardiovascular risk factors in hypopituitary GH-deficient adults Eur. J. Endocrinol., November 1, 2009; 161(S1): S41 - S49. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Filipsson and G. Johannsson GH replacement in adults: interactions with other pituitary hormone deficiencies and replacement therapies Eur. J. Endocrinol., November 1, 2009; 161(S1): S85 - S95. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Colao, C. Di Somma, S. Savastano, F. Rota, M. C. Savanelli, G. Aimaretti, and G. Lombardi A Reappraisal of Diagnosing GH Deficiency in Adults: Role of Gender, Age, Waist Circumference, and Body Mass Index J. Clin. Endocrinol. Metab., November 1, 2009; 94(11): 4414 - 4422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Abrams, H. Boquete, H. Fideleff, U. Feldt-Rasmussen, P. J Jonsson, M. Koltowska-Haggstrom, P. Wilton, and R. Abs GH replacement in hypopituitarism improves lipid profile and quality of life independently of changes in obesity variables Eur. J. Endocrinol., December 1, 2008; 159(6): 825 - 832. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-L. Norrman, G. Johannsson, K. S. Sunnerhagen, and J. Svensson Baseline Characteristics and the Effects of Two Years of Growth Hormone (GH) Replacement Therapy in Adults with GH Deficiency Previously Treated for Acromegaly J. Clin. Endocrinol. Metab., July 1, 2008; 93(7): 2531 - 2538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Stochholm, T. Laursen, A. Green, P. Laurberg, M. Andersen, L. O. Kristensen, U. Feldt-Rasmussen, J. S. Christiansen, M. Frydenberg, and C. H. Gravholt Morbidity and GH deficiency: a nationwide study. Eur. J. Endocrinol., April 1, 2008; 158(4): 447 - 457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. R Walker Glucocorticoids and Cardiovascular Disease Eur. J. Endocrinol., November 1, 2007; 157(5): 545 - 559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Holmer, J. Svensson, L. Rylander, G. Johannsson, T. Rosen, B.-A. Bengtsson, M. Thoren, C. Hoybye, M. Degerblad, M. Bramnert, et al. Nonfatal Stroke, Cardiac Disease, and Diabetes Mellitus in Hypopituitary Patients on Hormone Replacement Including Growth Hormone J. Clin. Endocrinol. Metab., September 1, 2007; 92(9): 3560 - 3567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Stochholm, C. H. Gravholt, T. Laursen, P. Laurberg, M. Andersen, L. O. Kristensen, U. Feldt-Rasmussen, J. S. Christiansen, M. Frydenberg, and A. Green Mortality and GH deficiency: a nationwide study Eur. J. Endocrinol., July 1, 2007; 157(1): 9 - 18. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Gotherstrom, B.-A. Bengtsson, I. Bosaeus, G. Johannsson, and J. Svensson A 10-Year, Prospective Study of the Metabolic Effects of Growth Hormone Replacement in Adults J. Clin. Endocrinol. Metab., April 1, 2007; 92(4): 1442 - 1445. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rizzo, R. Trepp, K. Berneis, and E. R Christ Atherogenic lipoprotein phenotype and low-density lipoprotein size and subclasses in patients with growth hormone deficiency before and after short-term replacement therapy Eur. J. Endocrinol., March 1, 2007; 156(3): 361 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Bergthorsdottir, M. Leonsson-Zachrisson, A. Oden, and G. Johannsson Premature Mortality in Patients with Addison's Disease: A Population-Based Study J. Clin. Endocrinol. Metab., December 1, 2006; 91(12): 4849 - 4853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Abs, U. Feldt-Rasmussen, A. F Mattsson, J. P Monson, B.-A. Bengtsson, M. I Goth, P. Wilton, and M. Koltowska-Haggstrom Determinants of cardiovascular risk in 2589 hypopituitary GH-deficient adults - a KIMS database analysis. Eur. J. Endocrinol., July 1, 2006; 155(1): 79 - 90. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Svensson, G. Johannsson, A. Iranmanesh, K. Albertsson-Wikland, J. D Veldhuis, and B.-A. Bengtsson GH secretory pattern in young adults who discontinued GH treatment for GH deficiency and decreased longitudinal growth in childhood. Eur. J. Endocrinol., July 1, 2006; 155(1): 91 - 99. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bollerslev, T. Ueland, A. P Jorgensen, K. J Fougner, R. Wergeland, T. Schreiner, and P. Burman Positive effects of a physiological dose of GH on markers of atherogenesis: a placebo-controlled study in patients with adult-onset GH deficiency. Eur. J. Endocrinol., April 1, 2006; 154(4): 537 - 543. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Dalle and V. Claude Growth Hormone for "Antiaging" JAMA, February 22, 2006; 295(8): 889 - 889. [Full Text] [PDF]
|
|
|
|
|
|
J. Bollerslev, J. Hallen, K. J Fougner, A. P. Jorgensen, C. Kristo, H. Fagertun, O. Gudmundsen, P. Burman, and T. Schreiner Low-dose GH improves exercise capacity in adults with GH deficiency: effects of a 22-month placebo-controlled, crossover trial Eur. J. Endocrinol., September 1, 2005; 153(3): 379 - 387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gola, S. Bonadonna, M. Doga, and A. Giustina Growth Hormone and Cardiovascular Risk Factors J. Clin. Endocrinol. Metab., March 1, 2005; 90(3): 1864 - 1870. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
