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Metabolic, Anthropometric, and Nutritional Factors as Predictors of Circulating Insulin-Like Growth Factor Binding Protein-1 Levels in Middle-Aged and Elderly Men

Department of Medicine (K.W.), Karolinska Institutet, SE-17177 Stockholm; Division of Nutritional Epidemiology (S.C.L., A.W.), The National Institute of Environmental Medicine, Karolinska Institutet, SE-17177 Stockholm; Department of Public Health and Caring Sciences (B.V.), Unit of Clinical Nutrition, Uppsala University, SE-75125 Uppsala; and Department of Molecular Medicine (K.B.), Karolinska Institutet, SE-17176 Stockholm, Sweden

Address all correspondence and requests for reprints to: Katarina Wolk, Department of Medicine, Karolinska Institutet, P.O. Box 210, SE-171 77 Stockholm, Sweden. E-mail: katarina.wolk{at}ks.se.

Circulating IGF binding protein (IGFBP)-1 levels have been associated with insulin sensitivity, the metabolic syndrome, several cardiovascular risk factors, and possibly with cancer. We examined long-term nutrient intake and metabolic and anthropometric factors in relation to IGFBP-1 levels in 226 men, 42–76 yr old, who completed 14 24-h diet recall interviews. Spearman rank correlation coefficients were calculated. Serum IGFBP-1 levels were significantly inversely correlated with insulin, homeostasis model assessment-insulin resistance, and IGF-I and positively correlated with age. Furthermore, IGFBP-1 was inversely correlated with anthropometric measures reflecting obesity, somewhat stronger in middle-aged (<65 yr) than in older men. Serum IGFBP-1 increased with higher energy and carbohydrate intake but only in the younger age group. The difference in mean IGFBP-1 levels comparing men in the top quartile of carbohydrate intake with those in the bottom quartile was 45% in men of age 42–54 yr (P = 0.01). Insulin, body mass index, and carbohydrate intake together explained 39% of the variability in IGFBP-1 levels in men 42–54 yr of age, 27% in men 55–64 yr, and 6% in men 65 or more years old. Our data suggest that metabolic, anthropometric, and nutritional factors are important determinants of IGFBP-1 levels in healthy men.

This work was supported by grants from the Swedish Cancer Foundation and the Swedish Research Council/Medicine.

Abbreviations: BMI, Body mass index; HOMA, homeostasis model assessment; IGFBP, IGF binding protein.

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